Protein Alignment Esp and Slc26a4

DIOPT Version :10

• Sequence 1: NP_524490.2
• Gene: Esp / 42962
• FlyBaseID: FBgn0013953
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_035997.1
• Gene: Slc26a4 / 23985
• MGIID: 1346029
• Length: 780
• Species: Mus musculus
• Alignment Length: 657
• Identity: 165/657 - (25%)
• Similarity: 287/657 - (43%)
• Gaps: 166/657 - (25%)

  Fly    51 GKKVKPTVSTLDCT----------RSWLQDCQRRTFNRKTL-----------HKR--------LP 86
            |:...|.::...|:          .::.|..:||...|:||           .||        ||
Mouse     6 GRSEPPQLAEYSCSYTVSRPVYSELAFQQQRERRLPERRTLRDSLARSCSCSRKRAFGVVKTLLP 70

  Fly    87 ILGWLPKYNSQD-AVGDLVAGITVGLTVIPQALAYAGIAGLPVAYGLYASFVGCFVYIFLGSCKD 150
            ||.|||||..:: .:.|:::|::.||....|.:|||.:|.:||.:|||::|.....|...|:.:.
Mouse    71 ILDWLPKYRVKEWLLSDIISGVSTGLVGTLQGMAYALLAAVPVQFGLYSAFFPILTYFVFGTSRH 135

  Fly   151 VPMGPSAIVALLT--------------YQAAQGSWQKS------------VLLC----LLSGIVE 185
            :.:||..:|:|:.              ..:..||...|            |||.    ||.||::
Mouse   136 ISVGPFPVVSLMVGSVVLSMAPDDHFLVPSGNGSALNSTTLDTGTRDAARVLLASTLTLLVGIIQ 200

  Fly   186 LLMGLFGLGFLIDFVSGPVSSGFTSAVSLIILTSQIQSVLGITAKG-NTFVE-IWT--QVFHNIE 246
            |:.|...:||::.:::.|:..|||:|.:..:|.||::.||.::.|. |..:. |:|  ::|.||.
Mouse   201 LVFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYNGILSIIYTLIEIFQNIG 265

  Fly   247 HTRAGDTVLGLTCIVILLLMRSLSSCRIGPVDEKECSSFQRAVNKILWIVGTARNAILVVVCCIM 311
            .|...|.:.||..|::.:.::.|:            ..|:..:.     |......|:.::...:
Mouse   266 DTNIADFIAGLLTIIVCMAVKELN------------DRFKHRIP-----VPIPIEVIVTIIATAI 313

  Fly   312 GYMLHTEEH-------GAPFRVVGEIPPGLPSIQLPPTSLTANETSNGVAEGFVEMVHSMGSGLV 369
            .|..:.|::       ..|   .|.:||.|||:.|                 |.:|:.:..|..|
Mouse   314 SYGANLEKNYNAGIVKSIP---SGFLPPVLPSVGL-----------------FSDMLAASFSIAV 358

  Fly   370 VIPLISLMENIAICKAFA--NGKPVDASQELIAIGTANIFNSFVQAFPGTGALSRGAVNNASGVR 432
            |...|:    :::.|.:|  :...:|.:||.||.|.:|:|:.|...|..|.||||.||..::|.:
Mouse   359 VAYAIA----VSVGKVYATKHDYVIDGNQEFIAFGISNVFSGFFSCFVATTALSRTAVQESTGGK 419

  Fly   433 TPLSNIYSGGLVMIALLFLTPYFYFIPRPTLAAIIISAV--VFMIEVKVVKPMWRSKKSDLVPGV 495
            |.::.:.|..:||:|::.|......:.:..|||::|:.:  :|| :|..|..:|:..|:|.|..|
Mouse   420 TQVAGLISAVIVMVAIVALGRLLEPLQKSVLAAVVIANLKGMFM-QVCDVPRLWKQNKTDAVIWV 483

  Fly   496 GTFVACLVLPLEWGILIGVGLNVIFILYHAARPKLSTELLTTQSGVEY-------SMITPDRCLI 553
            .|.:..::|.|:.|:|.|                |...|||....|::       |:.:.|   |
Mouse   484 FTCIMSIILGLDLGLLAG----------------LLFALLTVVLRVQFPSWNGLGSVPSTD---I 529

  Fly   554 FPSVDYVRNLVNKQSIR-------------------QNVPVVIDASHVYGADFTTATVIDSLISD 599
            :.|:.:.:||...:.::                   .|..|..||..||.........|..||
Mouse   530 YKSITHYKNLEEPEGVKILRFSSPIFYGNVDGFKKCINSTVGFDAIRVYNKRLKALRRIQKLI-- 592

  Fly   600 FNQRGQL 606
              ::|||
Mouse   593 --KKGQL 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_524490.2	SUL1	93..622	CDD:440424	147/586 (25%)
Slc26a4	NP_035997.1	PRK11660	70..725	CDD:481320	153/593 (26%)