DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esp and sulp-6

DIOPT Version :9

Sequence 1:	NP_001189282.1	Gene:	Esp / 42962	FlyBaseID:	FBgn0013953	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_491138.2	Gene:	sulp-6 / 189085	WormBaseID:	WBGene00020914	Length:	823	Species:	Caenorhabditis elegans

Alignment Length:	552	Identity:	129/552 - (23%)
Similarity:	234/552 - (42%)	Gaps:	112/552 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TISISTNLTEPNGSSNSVGSQGSKEFILTEDGKKVKPTVSTLDCTRSWLQDCQRRTFNRKTLHKR 84
            |:...|.|.:|...|.:    |...|.|...||..:         :.|:|      |.|    .|
Worm    39 TVFDKTYLFKPEYLSLT----GKIAFHLKSIGKWKR---------KEWIQ------FAR----GR 80

  Fly    85 LPILGWLPKYN-SQDAVGDLVAGITVGLTVIPQALAYAGIAGLPVAYGLYASFVGCFVYIFLGSC 148
            :||..|||:|. ..:.:.|.:.|:.|.:..:||:|||..:.|:|.:|||....:|..:|...|:.
Worm    81 IPITMWLPRYTWKSNFLVDFLGGLMVSVLSVPQSLAYGMLVGVPPSYGLITGIIGPIIYALFGTS 145

  Fly   149 KDVPMGPSAIVALLTYQAAQ-----GSWQKSV-----LLC---------------------LLSG 182
            |....|..|||:|:.....:     ||...::     |||                     ||.|
Worm   146 KHSSPGAFAIVSLMVGTVVESFGDVGSTNGTIDSNVDLLCCRENKPRVSDGDAIGIAASVTLLVG 210

  Fly   183 IVELLMGLFGLGFLIDFVSGPVSSGFTSAVSLIILTSQIQSVLGITAKGNTFVEIWTQVFHNIEH 247
            :.::|.||...|.|..::|..:..|..|..::.:||||::|:..|:....|.......||:....
Worm   211 LFQILFGLLNAGLLAVWLSDQLVQGLISGAAVHVLTSQLKSMTRISNVPPTSEPFQNVVFYMCFF 275

  Fly   248 TRAGDT-----VLGLTCIVILLLMRSLSSCRIGPVDEKECSSFQRAVNKILWI-----VGTARNA 302
            .:..|.     ::.:.|:|:||    :|:..|.|                 |:     |......
Worm   276 KQMPDVDYASIIISVICVVLLL----ISTLVIDP-----------------WLCKKVPVKFPMEL 319

  Fly   303 ILVVVCCIMGYMLHTEEHGAPFRVVGEIPPGLPSIQLPPTSLTANETSNGVAEGFVEMVHSMGSG 367
            :|||...:..:......:......||::..|:|:..:||.     ..:.|:          |||.
Worm   320 VLVVSMTLTVHYTRNTAYEFQIPTVGQVTSGIPAPVIPPM-----RNAFGM----------MGSA 369

  Fly   368 LVVIPLISLMENIAICKAFANGKP--VDASQELIAIGTANIFNSFVQAFPGTGALSRGAVNNASG 430
            : .|.:||.:.:|::||..:....  |:::||..|:|..:..:||...|.|..:|.|..:....|
Worm   370 M-SIAIISFVIHISLCKLISKKLQYVVNSNQEWFALGLMHTTSSFFGCFAGGSSLGRTMMQVKCG 433

  Fly   431 VRTPLSNIYSGGLVMIALLFL----TPYFYFIPRPTLAAIIISAVV-FMIEVKVVKPMWRSKKSD 490
            .::.||.:.:.   ::.::|:    ......:|:|.||:|::.|:. ..|::.....:.:....|
Worm   434 TKSQLSTLITS---IVLIIFVCGGAVGCIQHLPKPVLASIVVVAMKDLFIQIFTCFALRKLSFVD 495

  Fly   491 LVPGVGTFVACLVLPLEWGILIGVGLNVIFIL 522
            .:....||::.:||.:.:|:||||...::.::
Worm   496 YLIFAATFISVIVLNVNFGLLIGVVFELLTVV 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_001189282.1	sulP	86..615	CDD:273284	114/486 (23%)
		HCO3_cotransp	103..520	CDD:304903	107/464 (23%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913
sulp-6	NP_491138.2	sulP	82..725	CDD:273284	114/486 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740