Protein Alignment Esp and SLC26A2

DIOPT Version :9

• Sequence 1: NP_001189282.1
• Gene: Esp / 42962
• FlyBaseID: FBgn0013953
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_000103.2
• Gene: SLC26A2 / 1836
• HGNCID: 10994
• Length: 739
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 151/613 - (24%)
• Similarity: 264/613 - (43%)
• Gaps: 113/613 - (18%)

  Fly    22 SISTNLTEPNGSSNSVGSQGSKEFILTEDGKKVKPTVSTLDCTRSWLQDCQRRTFNRKTLHKR-- 84
            |...|.:.|:|....:..:.|.:|...|...:.:|....| ..|....|...:.|..|.|.|.
Human    16 SAEGNDSYPSGIHLELQRESSTDFKQFETNDQCRPYHRIL-IERQEKSDTNFKEFVIKKLQKNCQ 79

  Fly    85 -------------LPILGWLPKYN-SQDAVGDLVAGITVGLTVIPQALAYAGIAGLPVAYGLYAS 135
                         ||:|.|||||: .::.:||:::|:.||:.::||::||:.:||....||||.|
Human    80 CSPAKAKNMILGFLPVLQWLPKYDLKKNILGDVMSGLIVGILLVPQSIAYSLLAGQEPVYGLYTS 144

  Fly   136 FVGCFVYIFLGSCKDVPMGPSAIVALLTYQAAQGSWQK------------------SVLL----- 177
            |....:|..||:.:.:.:|...::.|:..:......||                  |.||
Human   145 FFASIIYFLLGTSRHISVGIFGVLCLMIGETVDRELQKAGYDNAHSAPSLGMVSNGSTLLNHTSD 209

  Fly   178 ------C----------LLSGIVELLMGLFGLGFLIDFVSGPVSSGFTSAVSLIILTSQIQSVLG 226
                  |          .::|:.::.||.|.:||:..::|..:.|||.:..|..|||||.:.:||
Human   210 RICDKSCYAIMVGSTVTFIAGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLG 274

  Fly   227 I----TAKGNTFVEIWTQVFHNIEHTRAGDTVLGLTCIVILLLMRSLSSCRIGPVDEKECSSFQR 287
            :    |....:.:..|..||.||..|...|.:..|.|:::||..:.|:            ..|:.
Human   275 LNLPRTNGVGSLITTWIHVFRNIHKTNLCDLITSLLCLLVLLPTKELN------------EHFKS 327

  Fly   288 AVNKILWIVGTARNAILVVVCCIMGYM--LHTEEHGAPFRVVGEIPPGLPSIQLPPTSLTANETS 350
            .:...:.|     ..::||...:..:.  ||...:.:   :.|.||.|....::|..:|
Human   328 KLKAPIPI-----ELVVVVAATLASHFGKLHENYNSS---IAGHIPTGFMPPKVPEWNL------ 378

  Fly   351 NGVAEGFVEMVHSMGSGLVVIPLISLMENIAICKAFA--NGKPVDASQELIAIGTANIFNSFVQA 413
                      :.|:....:.|.:|.....:::.:.||  :|..|.|:||:.|||..||..||...
Human   379 ----------IPSVAVDAIAISIIGFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHC 433

  Fly   414 FPGTGALSRGAVNNASGVRTPLSNIYSGGLVMIALLFLTPYFYFIPRPTLAAI-IISAVVFMIEV 477
            |..:.||::..|..::|..|.||.:.:..::::.||.:.|.||.:.:..|..| |::....:.:.
Human   434 FTTSAALAKTLVKESTGCHTQLSGVVTALVLLLVLLVIAPLFYSLQKSVLGVITIVNLRGALRKF 498

  Fly   478 KVVKPMWRSKKSDLVPGVGTFVACLVLPLEWGILIGVGLNVIFILYHAARPKLSTELLTTQSGVE 542
            :.:..||...:.|.|....|.::..:|..|.|:|:||..::..::....:||.|...|..:|.|
Human   499 RDLPKMWSISRMDTVIWFVTMLSSALLSTEIGLLVGVCFSIFCVILRTQKPKSSLLGLVEESEV- 562

  Fly   543 YSMITPDRCLIFPSVDYVRNLVNKQSIR 570
                       |.||...:||..|..|:
Human   563 -----------FESVSAYKNLQIKPGIK 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_001189282.1	sulP	86..615	CDD:273284	135/534 (25%)
		HCO3_cotransp	103..520	CDD:304903	113/464 (24%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913	7/26 (27%)
SLC26A2	NP_000103.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		3/10 (30%)
		sulP	94..715	CDD:273284	135/534 (25%)
		STAS	570..707	CDD:132911	4/10 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810