DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esp and Slc26a2

DIOPT Version :9

Sequence 1:	NP_001189282.1	Gene:	Esp / 42962	FlyBaseID:	FBgn0013953	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_476468.1	Gene:	Slc26a2 / 117267	RGDID:	620622	Length:	739	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	141/554 - (25%)
Similarity:	250/554 - (45%)	Gaps:	94/554 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 RSWLQDCQ-RRTFNRKTLHKRLPILGWLPKYN-SQDAVGDLVAGITVGLTVIPQALAYAGIAGLP 127
            |...:.|| ..|..|..:....|:|.|||||: .::.:||:::|:.||:.::||::||:.:||..
  Rat    72 RKLQKSCQCNATKIRNRIFDFFPVLRWLPKYDLKKNILGDMMSGLIVGILLVPQSIAYSLLAGQE 136

  Fly   128 VAYGLYASFVGCFVYIFLGSCKDVPMGPSAIVALLTYQAAQGSWQKSVL---------------- 176
            ..||||.||....:|...|:.:.:.:|...|:.|:..:.......|:..
  Rat   137 PIYGLYTSFFASIIYFLFGTSRHISVGIFGILCLMIGEVVDRELHKACPDIDTTSSSIAMFSNGC 201

  Fly   177 ---------LC--------------LLSGIVELLMGLFGLGFLIDFVSGPVSSGFTSAVSLIILT 218
                     ||              .::|:.::.||.|.:||:..::|..:.|||.:..|..|||
  Rat   202 VVVNHTLDGLCDKSCYAIKIGSTVTFMAGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILT 266

  Fly   219 SQIQSVLGIT---AKG-NTFVEIWTQVFHNIEHTRAGDTVLGLTCIVILLLMRSLSSCRIGPVDE 279
            ||.:.:||::   :.| .:.:..|..:|.||..|...|.:..|.|:::|             |..
  Rat   267 SQAKYLLGLSLPRSNGVGSVITTWIHIFRNIHKTNICDLITSLLCLLVL-------------VPT 318

  Fly   280 KECSSFQRAVNKILWIVGTARNAILVVVCCIMGYMLHTEEHGAPFRVVGEIPPGLPSIQLPPTSL 344
            ||.:.:.:  :|:...:.|   .::|||...:..............:.|:||.|....|.|..||
  Rat   319 KELNEYFK--SKLPAPIPT---ELIVVVAATLASHFGKLNENYNSSIAGQIPTGFMPPQAPDWSL 378

  Fly   345 TANETSNGVAEGFVEMVHSMGSGLVVIPLISLMENIAICKAFA--NGKPVDASQELIAIGTANIF 407
            ..|...:.:|                |.:|.....:::.:.||  :|..|.|:||:.|||..||.
  Rat   379 IPNVAVDAIA----------------ISIIGFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNII 427

  Fly   408 NSFVQAFPGTGALSRGAVNNASGVRTPLSNIYSGGLVMIALLFLTPYFYFIPRPTLAAI-IISAV 471
            .||......:.||::..|..::|.:|.||.|.:..::::.||.:.|.||.:.:..|..| |::..
  Rat   428 PSFFHCITTSAALAKTLVKESTGCQTQLSAIVTSLVLLLVLLLIAPLFYSLQKCVLGVITIVNLR 492

  Fly   472 VFMIEVKVVKPMWRSKKSDLVPGVGTFVACLVLPLEWGILIGVGLNVIFILYHAARPKLSTELLT 536
            ..:::.:.:..|||..:.|.|....|.::..:|..|.|:|:||..::..::.....||:|  ||
  Rat   493 GALLKFRDLPKMWRLSRMDTVIWFVTMLSSALLSTEIGLLVGVCFSMFCVILRTQMPKIS--LL- 554

  Fly   537 TQSGVEYSMITPDRCLIFPSVDYVRNLVNKQSIR 570
               |:|      :...||.|:...:||.:|..|:
  Rat   555 ---GLE------EESEIFESISTYKNLRSKSGIK 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_001189282.1	sulP	86..615	CDD:273284	136/532 (26%)
		HCO3_cotransp	103..520	CDD:304903	113/462 (24%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913	7/26 (27%)
Slc26a2	NP_476468.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		sulP	94..715	CDD:273284	136/532 (26%)
		STAS	570..707	CDD:294402	4/10 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810