Protein Alignment Esp and SLC26A8

DIOPT Version :10

• Sequence 1: NP_524490.2
• Gene: Esp / 42962
• FlyBaseID: FBgn0013953
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_443193.1
• Gene: SLC26A8 / 116369
• HGNCID: 14468
• Length: 970
• Species: Homo sapiens
• Alignment Length: 678
• Identity: 154/678 - (22%)
• Similarity: 272/678 - (40%)
• Gaps: 202/678 - (29%)

  Fly    66 SWLQDCQRRTFNRKTL---HKR-----------------------------------LPILGWLP 92
            |:..|.:|..:|.:|.   |||                                   .|.|.|:.
Human    20 SFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCVLTIFPFLEWMC 84

  Fly    93 KYNSQD-AVGDLVAGITVGLTVIPQALAYAGIAG--LPVAYGLYASFVGCFVYIFLGSCKDVPMG 154
            .|..:| .:|||:|||:|||..:||.|..:.:|.  :|.....||:|....:|:..|||..:.:|
Human    85 MYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIG 149

  Fly   155 PSAIVALLTY-----------QAAQGSWQK------SVLL------------CLLSGIVELLMGL 190
            ...:|:.|..           |...||:.|      |.|:            ..|:||::|:||:
Human   150 SFFLVSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQLIMGV 214

  Fly   191 FGLGFLIDFVSGPVSSGFTSAVSLIILTSQIQSVLGITAKGNT-----FVEIWTQVFHNIEHTRA 250
            .||||:..::.....|.:.:||:|.|:.||:..:.||....:.     |.:|   :.:.:...:|
Human   215 LGLGFIATYLPESAMSAYLAAVALHIMLSQLTFIFGIMISFHAGPISFFYDI---INYCVALPKA 276

  Fly   251 GDTVLGLTCIVILLLMRSLSSCRIG--------PVDEKECSSFQRAVNKILWIVGTARNAILVVV 307
            ..|.: |..:.:::.:|.....||.        |::......|....|||.....|::..|.::
Human   277 NSTSI-LVFLTVVVALRINKCIRISFNQYPIEFPMELFLIIGFTVIANKISMATETSQTLIDMI- 339

  Fly   308 CCIMGYMLHTEEHGAPFRVVGEIPPG---LPSIQLPPTSLTANETSNGVAEGFVEMVHSMGSGLV 369
                           |:..:..:.|.   ||.|.|...||:       :...|:
Human   340 ---------------PYSFLLPVTPDFSLLPKIILQAFSLS-------LVSSFL----------- 371

  Fly   370 VIPLISLMENIAICKAFANGKPVDASQELIAIGTANIFNSFVQAFPGTGALSRGAVNNASGVRTP 434
               ||.|.:.||....::    |:::|:|||||..|:.:||.::...|||::|..:.:.||.|..
Human   372 ---LIFLGKKIASLHNYS----VNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQ 429

  Fly   435 LSNIYSGGLVMIALLFLTPYFYFIPRPTLAAIIISAVVFMIE-VKVVKPMWRSKKSDLVPGVGTF 498
            .:::...|::::.::.:..:||.:|...||.||:|.|:..:| :..:..:||..:.|....:.||
Human   430 FASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTF 494

  Fly   499 VACLVLPLEWGILIGVGLNVIFIL---YHAARPKLSTELLTTQSGVEYSMITPDRCLIFPSVDYV 560
            .:.:.|.|:.|::|.| ::..||.   .|.|:..|..::..|.              |:.|::..
Human   495 SSSIFLGLDIGLIISV-VSAFFITTVRSHRAKILLLGQIPNTN--------------IYRSINDY 544

  Fly   561 RNLVNKQSIRQNVPVVIDASHVYGADFTTATVIDSLISDFNQRGQLLFFYNLKPSICSIFEHVSA 625
            |.::       .:|.|                                         .||:..|:
Human   545 REII-------TIPGV-----------------------------------------KIFQCCSS 561

  Fly   626 AQFV-VYYQEQQLDELLKERNYVQKRLE 652
            ..|| |||.:.   :||||.:.|:..|:
Human   562 ITFVNVYYLKH---KLLKEVDMVKVPLK 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_524490.2	SUL1	93..622	CDD:440424	131/580 (23%)
SLC26A8	NP_443193.1	PRK11660	78..584	CDD:481320	145/616 (24%)
		Interaction with RACGAP1. /evidence=ECO:0000269|PubMed:11278976	664..970
		STAS_SulP_like_sulfate_transporter	<719..776	CDD:132913
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	858..970
		Trypan_PARP	<873..923	CDD:368653