DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esp and SLC26A1

DIOPT Version :9

Sequence 1:	NP_001189282.1	Gene:	Esp / 42962	FlyBaseID:	FBgn0013953	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_071325.2	Gene:	SLC26A1 / 10861	HGNCID:	10993	Length:	701	Species:	Homo sapiens

Alignment Length:	541	Identity:	138/541 - (25%)
Similarity:	246/541 - (45%)	Gaps:	105/541 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 CTRSWLQDCQRRTFNRKTLHKRLPILGWLPKYNSQD-AVGDLVAGITVGLTVIPQALAYAGIAGL 126
            |.|:.:||.             ||...||.:|..:: ..||:::|:.:|:.::|||:||:.:|||
Human    45 CVRALVQDL-------------LPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGL 96

  Fly   127 PVAYGLYASFVGCFVYIFLGSCKDVPMGPSAIVALLTYQAAQGSWQ----------------KSV 175
            ...|.||.||....:|..:|:.:.|.:|..:::.|:..|......|                .|.
Human    97 QPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPGANSST 161

  Fly   176 L---------------------LCLLSGIVELLMGLFGLGFLIDFVSGPVSSGFTSAVSLIILTS 219
            |                     |.|::|:.::|||:..|||:..::|.|:..||....|:.||||
Human   162 LNGSAAMLDCGRDCYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGASVTILTS 226

  Fly   220 QIQSVLGITA---KGNTFVEI-WTQVFHNIEHTRAGDTVLGLTCIVILLLMRSLSSCRIGPVDEK 280
            |::.:||:..   :|...|.: |..:..........|.|....|:.:||..:.||
Human   227 QLKHLLGVRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVTSTVCLAVLLAAKELS---------- 281

  Fly   281 ECSSFQRAVNKILWIVGTARNAILVVVCCIMGY--MLHTEEHGAPFRVVGEIPPGLPSIQLPPTS 343
                 .|..:::.  |......:::||..::.:  .|| :..|:  .|.|:||.|....|:|...
Human   282 -----DRYRHRLR--VPLPTELLVIVVATLVSHFGQLH-KRFGS--SVAGDIPTGFMPPQVPEPR 336

  Fly   344 LTANETSNGVAEGFVEMVHSMGSGLVVIPLISLMENIAICKAFA--NGKPVDASQELIAIGTANI 406
            |......:.||                :.|::...:|::.:.||  :|..|.|:|||:|:|..|:
Human   337 LMQRVALDAVA----------------LALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNV 385

  Fly   407 FNSFVQAFPGTGALSRGAVNNASGVRTPLSNIYSGGLVMIALLFLTPYFYFIPRPTLAAIIISAV 471
            ..:|:..|..:.||::..|..|:|.||.||::.|..:|::.||.|.|.|:.:.|..||.:|:.::
Human   386 LPAFLHCFATSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSL 450

  Fly   472 VFMI-EVKVVKPMWRSKKSDLVPGVGTFVACLVLPLEWGILIGVGLNVIFILYHAARPKLSTELL 535
            ...: :|..:..:||...:|.:...||...|:::..|.|:|.||.|:::.:.....||:  |.||
Human   451 RGALRKVWDLPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPR--TALL 513

  Fly   536 TT-------QSGVEYSMITPD 549
            ..       :...|:..:.|:
Human   514 ARIGDTAFYEDATEFEGLVPE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_001189282.1	sulP	86..615	CDD:273284	133/518 (26%)
		HCO3_cotransp	103..520	CDD:304903	120/462 (26%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913	1/5 (20%)
SLC26A1	NP_071325.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		sulP	55..683	CDD:273284	133/518 (26%)
		STAS_SulP_like_sulfate_transporter	528..669	CDD:132913	1/7 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810