DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Esp and slc26a10

DIOPT Version :9

Sequence 1:	NP_001189282.1	Gene:	Esp / 42962	FlyBaseID:	FBgn0013953	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_031753035.1	Gene:	slc26a10 / 100485722	XenbaseID:	XB-GENE-6043616	Length:	693	Species:	Xenopus tropicalis

Alignment Length:	708	Identity:	161/708 - (22%)
Similarity:	291/708 - (41%)	Gaps:	182/708 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 KPTVSTLD-----CTRSWLQDCQRRTFNRKTLH---KRLPILGWLPKYNSQD-AVGDLVAGITVG 110
            :|.:|..|     ||      |....|    ||   :|:|||.|||:|..:. .:|||:||:|||
Frog    28 RPPLSLRDRIARSCT------CSAHAF----LHLLKRRVPILSWLPRYKLKKWLLGDLIAGLTVG 82

  Fly   111 LTVIPQALAYAGIAGLPVAYGLYASFVGCFVYIFLGSCKDVPMGPSAIVALLTYQAAQGSWQKSV 175
            :..|||.:|:|.:..:...:|||.||....:|:.||:...|..|..|:::|:|.........::.
Frog    83 IVHIPQGMAFALLTSVAPVHGLYTSFFPVVLYMLLGTGHHVSTGTFAVLSLMTGSVIDEHLPQNP 147

  Fly   176 L----------------------LCLLSGIVELLMGLFGLGFLIDFVSGPVSSGFTSAVSLIILT 218
            |                      :..|.|::.:.|.:..||||..::|.|:...||:|.:..:..
Frog   148 LDRNLTSEEQSDIYAQRIGMAAAIAFLIGVIMVAMFVLQLGFLSTYLSEPIVKAFTNAAAFHVTI 212

  Fly   219 SQIQSVLGITA---KGN-TFVEIWTQVFHNIEHTRAGDTVLGLTCIVILLLMRSLSSCRIGPVDE 279
            ||||::||:..   .|: |..:....|..::..|...:.|:.:.|:::|:.::.|::
Frog   213 SQIQNMLGLPLPRFTGSFTIFKTLVSVVQSLPMTNVAELVISILCLIVLIPIKELNA-------- 269

  Fly   280 KECSSFQRAVNKILWIVGTARNAI---LVVVCCIMGYMLHTE-EHGAPFRVVGEIPPGLPSIQLP 340
                   |...|:       |..|   :|:|....|....:. :.....::||.||.|.|:.:||
Frog   270 -------RFRTKL-------RTPIPGEIVMVLVATGVTFASSLDSRYNVQIVGSIPAGFPAPKLP 320

  Fly   341 PTSLTANETSNGVAEGFVEMVHSMGSGLVVIPLISLMENIAICKAFANGKPVDASQELIAIGTAN 405
            ...:......:.:|..||....|:              ::|:..|..:...:|.:|||:|.|.:|
Frog   321 SLKVIPKVVGDTIAITFVGYAVSV--------------SLAMIYAEKHRYSIDPNQELLAHGISN 371

  Fly   406 IFNSFVQAFPGTGALSRGAVNNASGVRTPLSNIYSGGLVMIALLFLTPYFYFIPRPTLAAI-IIS 469
            |.:|....||.:..|:...:..::|..|.||..::.|:|:|.|:::.|.|.::|:..||.| ::|
Frog   372 IVSSLFTCFPSSATLATTNILESAGGHTQLSGFFTSGVVLIVLIWIGPLFNYLPKAVLACINVVS 436

  Fly   470 AVVFMIEVKVVKPMWRSKKSDLVPGVGTFVACLVLPLEWGILIGVGLNVIFILYHAARPK----- 529
            .....::.:.:..:|:..|:|....|.|::|.:||.:|.|:.:||..:::.::....|.:
Frog   437 LRQMFLQFRELPELWKISKTDFSVWVVTWMAVVVLNVEVGLAVGVVFSMMTVVCRTQRAQCTVMG 501

  Fly   530 --LSTEL------------------------------------------LTTQ------------ 538
              :|||:                                          ||.:
Frog   502 RAVSTEIYRPVEQNDKCYEIPGLKILSYNSPIYYGNRDIFKDAVSRIVGLTQEKIRKREKALLVL 566

  Fly   539 ------------SGVEYSMITPDRCLIFPSVDYVRNLVNKQSIRQNVPVVIDASHVYGADFTTAT 591
                        ||:...:...|.|::.|..|           .:...::||.:.|...|...|.
Frog   567 EQARKMDISVVDSGIANPVFHQDGCILKPEAD-----------METKSLIIDCTGVIFIDSAGAR 620

  Fly   592 VIDSLISDFNQRGQLLFFYNLKPSI-----CS-IFEHVSAAQFVV------YYQEQQL 637
            :...:.:|..:.|..|........:     || |.:|:||.|..|      .|.||.:
Frog   621 LFIQMCTDCQKAGMHLLLAGCNEKVLRTLQCSGIMDHLSAEQVFVTVHDAACYAEQNM 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Esp	NP_001189282.1	sulP	86..615	CDD:273284	140/633 (22%)
		HCO3_cotransp	103..520	CDD:304903	111/447 (25%)
		STAS_SulP_like_sulfate_transporter	545..623	CDD:132913	15/83 (18%)
slc26a10	XP_031753035.1	sulP	57..670	CDD:273284	148/659 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.940