DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K11 and KIN4

DIOPT Version :9

Sequence 1:	NP_002410.1	Gene:	MAP3K11 / 4296	HGNCID:	6850	Length:	847	Species:	Homo sapiens
Sequence 2:	NP_014876.1	Gene:	KIN4 / 854408	SGDID:	S000005759	Length:	800	Species:	Saccharomyces cerevisiae

Alignment Length:	802	Identity:	169/802 - (21%)
Similarity:	265/802 - (33%)	Gaps:	270/802 - (33%)

- Green bases have known domain annotations that are detailed below.

Human   112 ASFQELRLEEVIGIGGFGKVYRGSWR--------GELVAVKAARQD---PDEDISVTAESVRQEA 165
            |:|....:...:|.|.||||..| |.        .:.||:|..|:|   .|.|..:   .:.:|.
Yeast    41 ATFGPYIIGSTLGEGEFGKVKLG-WTKASSSNEVPKQVAIKLIRRDTIKKDADKEI---KIYREI 101

Human   166 RLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRAL-AGRRVPPHVLVNWAVQIARGMHYL 229
            .....|.|||||.|:.|......:.:|:|:.:||...:.: ..||:..........|:..|::|:
Yeast   102 NALKHLTHPNIIYLEEVLQNSKYIGIVLEFVSGGEFYKYIQRKRRLKESSACRLFAQLISGVNYM 166

Human   230 HCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQM--SAAGTYAWMAPE 292
            |.:.||   |||||..|:||        .:|:.|.|||||...|:.:..::  ::.|:..:.|||
Yeast   167 HYKGLV---HRDLKLENLLL--------DKHENLVITDFGFVNEFFEDNELMKTSCGSPCYAAPE 220

Human   293 VIKASTF--SKGSDVWSFGVLLWELLTGEVPY-------RGIDCLAVAYGVAVNKLTLPIPSTCP 348
            ::.::..  ::.:||||.||:|:.:|.|.:|:       .| |.:|..|     |.....|...|
Yeast   221 LVVSTKAYEARKADVWSCGVILYAMLAGYLPWDDDHENPTG-DDIARLY-----KYITQTPLKFP 279

Human   349 EPFAQLMADCWAQ----DPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDE 409
            |....:..|...:    :|.||.:       |:.::..|..: |.::|.|:|..:       :||
Yeast   280 EYITPIPRDLLRRILVPNPRRRIN-------LQTIKRHVWLK-PHEAFLSIQPNY-------WDE 329

Human   410 LRAKEKELLSREEELTRAA--REQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVR 472
            ...||:.....:.::.|.:  ....|...:.|.|..|:.:..||...     :..|:...||
Yeast   330 HLQKERPKPPNKGDVGRHSTYSSSASSYSKSRDRNSLIIESTLEQHR-----MSPQLATSRP--- 386

Human   473 RRRGTFKR-SKLRARD----------GGERISMPLDF------------------------KHR- 501
             ...||.. ||:...|          .|||.|....:                        ||.
Yeast   387 -ASPTFSTGSKVVLNDTKNDMKESNINGERTSASCRYTRDSKGNGQTQIEQVSARHSSRGNKHTS 450

Human   502 ----ITVQASPGLDRRRNVFEVGPGDSPT---------------FPRFRAIQLEPAEPGQAWGRQ 547
                :|:..||...|.||    .|....|               |.|.....:.         |.
Yeast   451 VAGLVTIPGSPTTARTRN----APSSKLTEHVKDSSQTSFTQEEFHRIGNYHVP---------RS 502

Human   548 SPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYL-------DSDDSSPLGS--- 602
            .||                 |:|..||.::|....|..|.....|       |:.|..||.:
Yeast   503 RPR-----------------PTSYYPGLSRNTADNSLADIPVNKLGSNGRLTDAKDPVPLNAIHD 550

Human   603 -------------PSTPPALNGNP-------------------------------------PRPS 617
                         .|..||...:|                                     ||.|
Yeast   551 TNKATISNNSIMLLSEGPAAKTSPVDYHYAIGDLNHGDKPITEVIDKINKDLTHKAAENGFPRES 615

Human   618 LEPEE------PKRPV--------------------PAERGSSSGTPKLIQRALLRGTALLASLG 656
            ::||.      .|.|.                    .::..|...:.|:.::......:|.:||.
Yeast   616 IDPESTSTILVTKEPTNSTDEDHVESQLENVGHSSNKSDASSDKDSKKIYEKKRFSFMSLYSSLN 680

Human   657 LGRDLQPPGGPGRERGESPTTPPTPTPAPCP---------TEPPPSPLICFSLKTPDSPPTPAPL 712
            ..|...      ..|......||..:..|..         |:..|..|       .|..|.|...
Yeast   681 GSRSTV------ESRTSKGNAPPVSSRNPSGQSNRSNIKITQQQPRNL-------SDRVPNPDKK 732

Human   713 LLDLGIPVGQRSAKSPRREEEP 734
            :.|..|   :.:|.|....|.|
Yeast   733 INDNRI---RDNAPSYAESENP 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K11	NP_002410.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	11..38
		SH3_MLK1-3	45..102	CDD:212992
		STKc_MLK3	113..379	CDD:271049	80/292 (27%)
		STYKc	117..376	CDD:214568	78/285 (27%)
		Leucine-zipper 1	403..424		4/20 (20%)
		Leucine-zipper 2	438..459		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..643		28/191 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..847		18/89 (20%)
KIN4	NP_014876.1	STKc_Kin4	44..313	CDD:270978	80/296 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910