DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAP3K11 and BCK1

DIOPT Version :9

Sequence 1:	NP_002410.1	Gene:	MAP3K11 / 4296	HGNCID:	6850	Length:	847	Species:	Homo sapiens
Sequence 2:	NP_012440.1	Gene:	BCK1 / 853350	SGDID:	S000003631	Length:	1478	Species:	Saccharomyces cerevisiae

Alignment Length:	271	Identity:	80/271 - (29%)
Similarity:	136/271 - (50%)	Gaps:	32/271 - (11%)

- Green bases have known domain annotations that are detailed below.

Human   121 EVIGIGGFGKVY--RGSWRGELVAVKAAR----QDPDEDISVTAESVRQEARLFAMLAHPNIIAL 179
            |:||.|.||.||  .....||::|||...    ...:|.|..|.|::|.|......|.|.||:
Yeast  1179 EMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNIV-- 1241

Human   180 KAVCLEEPN--LCLVMEYAAGGPLSRALA--GRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHR 240
            :.:..|..|  ..|.:||.|||.:...:.  ||...| ::.:...|:.:|:.|||.:.   ::||
Yeast  1242 QYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEP-LIKHLTTQVLKGLAYLHSKG---ILHR 1302

Human   241 DLKSNNILLLQPIESDDMEHKTLKITDFGLAR---EWHKTTQMSAAGTYAWMAPEVIKAST-FSK 301
            |:|::|:||    :.|.:    .||:|||::|   :.:..:.|:..||..|||||::.... :|.
Yeast  1303 DMKADNLLL----DQDGI----CKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSA 1359

Human   302 GSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQL----MADCWAQD 362
            ..|:||.|.::.|:..|:.|:..::.:|..:.:..:|...|||.......:|:    :..|:..:
Yeast  1360 KVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEIN 1424

Human   363 PHRRPDFASIL 373
            |.:||....:|
Yeast  1425 PEKRPTANELL 1435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K11	NP_002410.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	11..38
		SH3_MLK1-3	45..102	CDD:212992
		STKc_MLK3	113..379	CDD:271049	80/271 (30%)
		STYKc	117..376	CDD:214568	80/271 (30%)
		Leucine-zipper 1	403..424
		Leucine-zipper 2	438..459
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..643
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..847
BCK1	NP_012440.1	STKc_Bck1_like	1173..1440	CDD:270799	80/271 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910