DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K11 and BOI1

DIOPT Version :9

Sequence 1:	NP_002410.1	Gene:	MAP3K11 / 4296	HGNCID:	6850	Length:	847	Species:	Homo sapiens
Sequence 2:	NP_009468.1	Gene:	BOI1 / 852193	SGDID:	S000000181	Length:	980	Species:	Saccharomyces cerevisiae

Alignment Length:	757	Identity:	146/757 - (19%)
Similarity:	244/757 - (32%)	Gaps:	244/757 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    33 EGSPKAAGYAN-PVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQ--VGGQVGI 94
            ||:....|..: |::.|:..|....:|||.::.||:::|::.|...  ::||:.|:  ...:.|:
Yeast     4 EGNTLGKGAKSFPLYIAVNQYSKRMEDELNMKPGDKIKVITDDGEY--NDGWYYGRNLRTKEEGL 66

Human    95 FPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAE 159
            :|:.:..|.....|      :.|........|..|..|     |.|       .|...:|. ...
Yeast    67 YPAVFTKRIAIEKP------ENLHKSPTQESGNSGVKY-----GNL-------NDSASNIG-KVS 112

Human   160 SVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIAR 224
            |.:||.|..::.:..:.|. ||  |||.....|.:..:..|       .|||
Yeast   113 SHQQENRYTSLKSTMSDID-KA--LEELRSGSVEQEVSKSP-------TRVP------------- 154

Human   225 GMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWM 289
                   |...|    .|:....|:         :.||         |....||.
Yeast   155 -------EVSTP----QLQDEQTLI---------QEKT---------RNEENTTH---------- 180

Human   290 APEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQL 354
                  .|.||..:|:......|..:....:..:.::                 ||:  |...||
Yeast   181 ------DSLFSSTADLNLSSESLKNISKSNISTKSLE-----------------PSS--ESVRQL 220

Human   355 ---MADCWAQDPHRRPDFASIL-----------------QQLEALEAQVLREMPRDSFHSMQEGW 399
               ||..|:  |....|:.|::                 :.|..||.:.|:|:..:||     |.
Yeast   221 DLKMAKSWS--PEEVTDYFSLVGFDQSTCNKFKEHQVSGKILLELELEHLKELEINSF-----GI 278

Human   400 KREIQGLFDELRAKEKELLSREEEL-----TRAAREQRSQ---AEQLRRREHLLAQWELEVFERE 456
            :.:|   |.|:|..:..:.|...:|     |.|...|.:|   |..:.|.|     .:.::..:.
Yeast   279 RFQI---FKEIRNIKSAIDSSSNKLDADYSTFAFENQAAQLMPAATVNRDE-----IQQQISSKC 335

Human   457 LTLLLQQVDRERPHV----RRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVF 517
            ..|..:..||:...|    :|..........:..|..|:|         :.:...|.|...:::|
Yeast   336 NKLSSESSDRKSSSVTTELQRPSSVVVNPNFKLHDPAEQI---------LDMTEVPNLFADKDIF 391

Human   518 EVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERR--ACWAWGPSSPKPGEAQNG- 579
            | .||.:|..|.:.:    |.:|     .|||......:|...|  ....:.|.:..|....||
Yeast   392 E-SPGRAPKPPSYPS----PVQP-----PQSPSFNNRYTNNNARFPPQTTYPPKNKNPTVYSNGL 446

Human   580 --------------------------RRRSRMDEATW----YLDSDDSSPLGSPSTPPALNGNPP 614
                                      .|::.:..||.    .:::|:|.|..|..:..|.:.:|.
Yeast   447 IPNSSTSSDNSTGKFKFPAMNGHDSNSRKTTLTSATIPSINTVNTDESLPAISNISSNATSHHPN 511

Human   615 RPSLEPEEPKRPVPAERGSS----------------------SGTPKLIQRALLRGTALLASLGL 657
            |.|:.....||   .|.|||                      :..|....||:.......:|.|.
Yeast   512 RNSVVYNNHKR---TESGSSFVDLFNRISMLSPVKSSFDEEETKQPSKASRAVFDSARRKSSYGH 573

Human   658 GRDLQPPGGPGRER---------GESPTTPPTPTPAPCPTEP 690
            .||..........|         .:|.:.|.:||......:|
Yeast   574 SRDASLSEMKKHRRNSSILSFFSSKSQSNPTSPTKQTFTIDP 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K11	NP_002410.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	11..38		2/4 (50%)
		SH3_MLK1-3	45..102	CDD:212992	14/58 (24%)
		STKc_MLK3	113..379	CDD:271049	49/285 (17%)
		STYKc	117..376	CDD:214568	48/278 (17%)
		Leucine-zipper 1	403..424		5/20 (25%)
		Leucine-zipper 2	438..459		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..643		29/160 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..847		9/45 (20%)
BOI1	NP_009468.1	SH3_BOI	17..71	CDD:212819	14/55 (25%)
		SAM_superfamily	226..290	CDD:417767	16/73 (22%)
		PH_Boi	778..894	CDD:270126
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I3572
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000