DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K11 and slpr

DIOPT Version :9

Sequence 1:	NP_002410.1	Gene:	MAP3K11 / 4296	HGNCID:	6850	Length:	847	Species:	Homo sapiens
Sequence 2:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	907	Identity:	335/907 - (36%)
Similarity:	449/907 - (49%)	Gaps:	173/907 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    45 VWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYV--------- 100
            :||||:||:..|:|||.||:|:.|.|||.|:.:|||.|||.|::|.:||:||.::|
  Fly    47 LWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGVFPKDFVTDEDPLQLN 111

Human   101 --SRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQ 163
              |..|...|.|: .:.||.::||||.|||.||:||.:.||.||:|.|.|..::|:....::|.|
  Fly   112 VSSAIGDIQPHEI-EYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQ 175

Human   164 EARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHY 228
            ||:||..|.|.||.||:.||| ...||||||||.||.|:|.||| ::||.||||||:||||||:|
  Fly   176 EAKLFWALKHENIAALRGVCL-NTKLCLVMEYARGGSLNRILAG-KIPPDVLVNWAIQIARGMNY 238

Human   229 LHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEV 293
            ||.||.:.:|||||||:|:|:.:.||.:.::.|||||||||||||.:.|.:||||||||||.|||
  Fly   239 LHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMPPEV 303

Human   294 IKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADC 358
            |..||:||.|||||:|||||||:|||.||:|.|.|:||||||||.||||||.||||.:..||..|
  Fly   304 ISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSC 368

Human   359 WAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEK-------E 416
            |..|||:||.|..||:|||::........|::|||.|||.|::||.|:..:||.|||       |
  Fly   369 WQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEE 433

Human   417 LLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRS 481
            |.::||:|.|...|||.:|..|:.||..|.:.|..:.|||| ::||.|..:|.|   ::|  |::
  Fly   434 LRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIEREL-VMLQPVPSKRKH---KKG--KKN 492

Human   482 KLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGR 546
            |      ..:||:|..|:|.||...    |:...     || ||:|...|.:.|.....|:.||.
  Fly   493 K------PLQISLPTGFRHTITAVR----DKAEQ-----PG-SPSFSGLRIVALTDGHKGKTWGP 541

Human   547 QSPRRLEDS------SNGERRACW--------AWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDS 597
            .:..:.|.|      |.|:..  |        ::..|:|...:.|..:.:.:
  Fly   542 STMHQRERSLLPSQLSGGQPE--WPAQTSTHSSFSKSAPNLDKKQQQQNQQQ------------- 591

Human   598 SPLGSPSTPPAL---------NGNPPRPSLEPEEP---KRPVPAERGSSSGTPKLIQRAL----- 645
              :.|.:.||.|         .|.|..|.|.|..|   .||    ..::.|..|.|...:
  Fly   592 --VASLTPPPGLGILGGSGGAGGTPATPLLYPGIPIILTRP----NNNNIGNCKAITTTITTTTT 650

Human   646 --------------------LRGTALLASLGLGRDLQPPGGP--------GRERGESPTTPPTPT 682
                                |...:.:.|............|        ||....|.||..:|.
  Fly   651 TTTNNNNNNNNSISANNNNQLNNISTINSNNNNNQTNLTSQPNTIIVLQNGRNNSNSSTTSQSPA 715

Human   683 PA-------------PCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEP 734
            ..             |...:|||..|:.......|:..:|......|  ..|..||.|.......
  Fly   716 KIYHRARSQEYGLDHPLAYQPPPLYLVTDDSSETDTVASPTGCFHFL--KSGNSSAASGAVHLHR 778

Human   735 RGGTVSPPPGTSRSAPGTPGTPRSPPL-GLISRPRPSPL---------------RSRIDPWSFVS 783
            .||::...|...|.......:...||. |..|...|:.|               |..|...|..|
  Fly   779 FGGSLGNSPAVGRKKHSLDSSSHHPPANGSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMAS 843

Human   784 AGPRPSPLPSPQPAPRRAPWTLFPDSDPFW-----DSPPANPFQGGPQDCRAQTKDMGAQAP 840
            : .|.:...|       ...|::..|.|..     |:..|  |:||    |.|....|:|.|
  Fly   844 S-ERVNSKSS-------GDLTMYNSSTPLTARDCDDAEEA--FEGG----RFQRNFSGSQFP 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K11	NP_002410.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	11..38
		SH3_MLK1-3	45..102	CDD:212992	31/67 (46%)
		STKc_MLK3	113..379	CDD:271049	166/265 (63%)
		STYKc	117..376	CDD:214568	162/258 (63%)
		Leucine-zipper 1	403..424		11/27 (41%)
		Leucine-zipper 2	438..459		9/20 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..643		26/131 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..847		48/228 (21%)
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	31/56 (55%)
		TyrKc	129..386	CDD:197581	162/258 (63%)
		STKc_MLK	134..389	CDD:270963	163/256 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	340	1.000	Domainoid score	I1091
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3357
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001334
OrthoInspector	1	1.000	-	-		otm42198
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.720