DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K11 and fin1

DIOPT Version :9

Sequence 1:	NP_002410.1	Gene:	MAP3K11 / 4296	HGNCID:	6850	Length:	847	Species:	Homo sapiens
Sequence 2:	NP_593305.1	Gene:	fin1 / 2542237	PomBaseID:	SPAC19E9.02	Length:	722	Species:	Schizosaccharomyces pombe

Alignment Length:	804	Identity:	180/804 - (22%)
Similarity:	288/804 - (35%)	Gaps:	230/804 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   115 QELRLEEVIGIGGFGKVYRGS--WRGELVAVK------AARQDPDEDISVTAESVRQEARLFAML 171
            ::.::.|.||.|.||::|:..  ..|.|:|.|      ..||:        .:.:..|..:...|
pombe     2 EKYKILECIGHGSFGRIYKVQRLKDGALLAQKEIHFGNITRQE--------KQYIADEVNILRNL 58

Human   172 AHPNIIALKAVCLEEPN-----LCLVMEYAAGGPLSRAL-----AGRRVPPHVLVNWAVQIARGM 226
            .||||:   ..|.||.|     :.|.|||...|.|:..:     ..:|.....::.:..|:...:
pombe    59 KHPNIV---QYCGEELNRSAQVINLYMEYCGHGDLANLIQRYKEEKKRFTEQEVLKFFTQLLLAL 120

Human   227 HYLH-------CEALVP---------VIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWH 275
            :..|       |::..|         |:|||:|..||.|        .|:.::|:.||||::...
pombe   121 YRCHYGENAPACDSQWPREIFHPKQSVLHRDIKPANIFL--------DENNSVKLGDFGLSKLLD 177

Human   276 KT---TQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVN 337
            .|   || |..||..:|:||:|::|.:|..||||:.|.:::|:.....|:.|...|.:...:...
pombe   178 NTRVFTQ-SYVGTPYYMSPEIIRSSPYSAKSDVWALGCVIFEICMLTHPFEGRSYLELQRNICQG 241

Human   338 KLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQ-------QLEALEAQVLREMPRDSFHSM 395
            .|:                 ||  |.|...|...:::       .|.....|:||........|.
pombe   242 NLS-----------------CW--DHHYSDDVFLLIRHCLEVNSDLRPTTYQLLRSPILSDIRSK 287

Human   396 QEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHL---LAQWELEVFEREL 457
            .|. :|.:....|.|..|.:.|:..|.:|  ..||||..|.:......:   |||.| |:..|||
pombe   288 LES-ERVVLEQSDLLHKKHQMLIQLENDL--QFREQRLSARESELENVIASRLAQRE-EILRREL 348

Human   458 TLLLQQVD-RERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHR-----------ITVQAS--- 507
            ...|:.:| |.:.|::....:.::.         |::.|:|...:           .|::||
pombe   349 EKQLRDMDARYQRHMQTVVNSMQKM---------RVTSPVDHNEQPESSTAEMFVDCTIEASQSP 404

Human   508 ------------------PG---------LDR---RRNVFEVGPGDSPTFPRFRA----IQLEPA 538
                              ||         |.|   |:.:.......:.|..::||    ::..|.
pombe   405 LLHIPKLGISKPLQTLSCPGFTLTTQQPILKRPTLRKELSSRALHTTATLMKYRANASSLRTTPI 469

Human   539 E-PGQAWGRQSP------------RRLEDSSNGERRACWAWGPSSP----KPGEAQNGRRRSRM- 585
            : .||....|..            :.|..|.:|::.:     ||..    ..||....|:.|::
pombe   470 DKDGQITSLQQKNGTSNQVADCMNKLLHTSLDGKKLS-----PSELCNKFSDGEGLPNRKVSKLS 529

Human   586 ---DEATWYLDSDDSSPLGSPSTPPALNG---NPPRP-----------SLEPEEPKRPVPAERGS 633
               ||......|.:|.|..|..|......   :||.|           ::..:|..:|..|.:
pombe   530 VESDETAVSASSGESVPTDSTLTDTKSKSVFVHPPSPQSLYVEKLEKLNIRSDEVSKPSKASK-- 592

Human   634 SSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRER---GESPTTPPTPTPAPCPTEPPPSPL 695
                       .|.|.| |.||....|:.......||.   |...|......|..
pombe   593 -----------TLHGYA-LPSLASPYDVHAEEKIARENEMDGNFKTMKINQHPDE---------- 635

Human   696 ICFSLKTP-------DSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTP 753
              :.|:||       ....:|...|..||....:|||......|..:..:.|  ..||..:...|
pombe   636 --YVLRTPKKIQLLEGQKRSPVKQLGRLGYNKLRRSAMDNAGLELRKAASTS--NYTSLQSRTLP 696

Human   754 GTPRSPPLGLISRPRPSPLRSRID 777
            |:.|.....:   |||. ||..:|
pombe   697 GSWRDDEEEI---PRPF-LRKMLD 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K11	NP_002410.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	11..38
		SH3_MLK1-3	45..102	CDD:212992
		STKc_MLK3	113..379	CDD:271049	76/307 (25%)
		STYKc	117..376	CDD:214568	75/302 (25%)
		Leucine-zipper 1	403..424		5/20 (25%)
		Leucine-zipper 2	438..459		8/23 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..643		26/140 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..847		30/133 (23%)
fin1	NP_593305.1	STKc_Nek2	3..281	CDD:270857	79/316 (25%)
fin1	NP_593305.1	S_TKc	4..281	CDD:214567	79/315 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910