DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAP3K11 and byr1

DIOPT Version :9

Sequence 1:	NP_002410.1	Gene:	MAP3K11 / 4296	HGNCID:	6850	Length:	847	Species:	Homo sapiens
Sequence 2:	NP_593026.1	Gene:	byr1 / 2542137	PomBaseID:	SPAC1D4.13	Length:	340	Species:	Schizosaccharomyces pombe

Alignment Length:	344	Identity:	84/344 - (24%)
Similarity:	143/344 - (41%)	Gaps:	58/344 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    63 RKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSN---------YVSRGGGPPPCEVASFQELR 118
            |:..:..||:.:|::...:.....::......|.||         :::|    .|..::......
pombe     5 RRNPKGLVLNPNASVKSSDNDHKEELINNQKSFESNVEAFMEQCAHMNR----RPAWISDLDNSS 65

Human   119 LEEV--IGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAH---PNIIA 178
            ||.|  :|.|..|.|.....|...:|.|......|..:.      :|..|...:|.|   |.|:.
pombe    66 LEVVRHLGEGNGGAVSLVKHRNIFMARKTVYVGSDSKLQ------KQILRELGVLHHCRSPYIVG 124

Human   179 LKAVCLEEPNLCLVMEYAAGGPLSRAL-AGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDL 242
            .......:.|:.|.|||...|.|...| .|..:|..:|......:.:|:.||:  .::.:|||||
pombe   125 FYGAFQYKNNISLCMEYMDCGSLDAILREGGPIPLDILGKIINSMVKGLIYLY--NVLHIIHRDL 187

Human   243 KSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWS 307
            |.:|:::....|        :|:.|||::.|...:...:..||..:|:||.|:...::..||:||
pombe   188 KPSNVVVNSRGE--------IKLCDFGVSGELVNSVAQTFVGTSTYMSPERIRGGKYTVKSDIWS 244

Human   308 FGVLLWELLTGEVP--YRGID----------CLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA 360
            .|:.:.||.|.|:|  :..||          |:       |.:....:||:.||.....:..|.
pombe   245 LGISIIELATQELPWSFSNIDDSIGILDLLHCI-------VQEEPPRLPSSFPEDLRLFVDACL- 301

Human   361 QDPHRRPDFASILQQLEAL 379
               |:.|...:..|||.|:
pombe   302 ---HKDPTLRASPQQLCAM 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K11	NP_002410.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	11..38
		SH3_MLK1-3	45..102	CDD:212992	7/47 (15%)
		STKc_MLK3	113..379	CDD:271049	74/283 (26%)
		STYKc	117..376	CDD:214568	72/276 (26%)
		Leucine-zipper 1	403..424
		Leucine-zipper 2	438..459
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..643
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..847
byr1	NP_593026.1	PKc_Byr1_like	60..334	CDD:270792	75/285 (26%)
byr1	NP_593026.1	Pkinase	66..320	CDD:278497	75/279 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910