DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAP3K11 and SPAP27G11.07c

DIOPT Version :9

Sequence 1:	NP_002410.1	Gene:	MAP3K11 / 4296	HGNCID:	6850	Length:	847	Species:	Homo sapiens
Sequence 2:	NP_593411.1	Gene:	SPAP27G11.07c / 2541953	PomBaseID:	SPAP27G11.07c	Length:	238	Species:	Schizosaccharomyces pombe

Alignment Length:	184	Identity:	37/184 - (20%)
Similarity:	59/184 - (32%)	Gaps:	70/184 - (38%)

- Green bases have known domain annotations that are detailed below.

Human   131 VYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLF-----AMLAHPNI---IALKAVCLEEP 187
            :||.....:|..||...    |.|::..|....|..|.     ....||.:   ::.|. ||.|.
pombe    14 IYREIKEKKLTVVKQGA----EAITIKTEFYPGEVCLLKCRPAKRWRHPILDQKLSRKR-CLVEA 73

Human   188 NLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLH--------------CEA----- 233
            .|.....|          .|.:.|    :.:.:...||..|:.              ||.
pombe    74 RLLAKCHY----------VGIKCP----MLYFIDANRGQIYMEWIDGPCVRDYIREICECEIEKK 124

Human   234 LVP----------------VIHRDLKSNNILLLQPIESDDMEHKTLKI-TDFGL 270
            |:|                ::|.||.::|::|       :..:..:.| .||||
pombe   125 LIPLMKRIGSEVAKMHKNDIVHGDLTTSNMML-------ESHNNPVPIFIDFGL 171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K11	NP_002410.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	11..38
		SH3_MLK1-3	45..102	CDD:212992
		STKc_MLK3	113..379	CDD:271049	37/184 (20%)
		STYKc	117..376	CDD:214568	37/184 (20%)
		Leucine-zipper 1	403..424
		Leucine-zipper 2	438..459
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..643
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..847
SPAP27G11.07c	NP_593411.1	Bud32	23..238	CDD:226168	35/175 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910