DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K11 and mlk-1

DIOPT Version :9

Sequence 1:	NP_002410.1	Gene:	MAP3K11 / 4296	HGNCID:	6850	Length:	847	Species:	Homo sapiens
Sequence 2:	NP_001300151.1	Gene:	mlk-1 / 178895	WormBaseID:	WBGene00003374	Length:	1059	Species:	Caenorhabditis elegans

Alignment Length:	950	Identity:	227/950 - (23%)
Similarity:	350/950 - (36%)	Gaps:	319/950 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    42 ANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGP 106
            |:..:.|.::||....|||.|..|..:.:::.:   :.::||:.|::.|:||:|||||..
Worm    70 ASKAFVASYEYEAQKDDELNLPLGAIITLVTVE---TNEDGWYRGELNGKVGLFPSNYAR----- 126

Human   107 PPCEVA---SFQELRLEEV-------------IGIGGFGKVYR----------GSWRGELVA--V 143
               ||.   :..|.:.:|:             ||.|....|::          ....||.|.  :
Worm   127 ---EVTYKDNLVEFKQDEIMLPVAVRTLSDCQIGHGATATVFKMDIKIKKELQNGRMGEAVGDQM 188

Human   144 KAA-----------RQD---PDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVME 194
            |||           |.|   .||.:    |.:::||.|...|:|.||:.|..:|||:|...|::|
Worm   189 KAALKRFNRHASNFRADVVSTDEQL----EQLKREANLVNGLSHNNIVRLLGICLEDPYFGLLLE 249

Human   195 YAAGGPLSRAL----AGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPI-- 253
            ...|..|....    :...:|..||::||.|:|.||.||..:..|   |||||::|:|:.:.:
Worm   250 LCEGSSLRNVCRNLNSDAAIPLGVLIDWATQVAEGMEYLTKQGYV---HRDLKADNVLVKEEVCL 311

Human   254 -ESDDM--------------EHKTLKITDFGLAREW-HKTTQMSAAGTYAWMAPEVIKASTFSKG 302
             ..::|              :...|||||||:.|:. ....:.|.||||||:|||..|..|:|:.
Worm   312 CMDEEMFQYAYCLKCGKRPFDKLQLKITDFGVTRKMTADANRFSTAGTYAWLAPEAFKEGTWSEA 376

Human   303 SDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRP 367
            |||||:||:||||||.|.||:|.....:|:.:|.....|.|..:||:.:.:||.|||..:|:.||
Worm   377 SDVWSYGVVLWELLTREEPYQGHIPATIAFQIANKGQNLSIGDSCPDRWKKLMQDCWNLEPNFRP 441

Human   368 DFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDEL---RAKEK------ELLSREEE 423
            .|:::....:    |..:|. :|: |..:...|..::.|:.|.   :.||:      :|.:...:
Worm   442 KFSTLAISFK----QYAKEF-KDT-HLQRAPSKMAVKELYSECFADKTKEEFEKRFHDLYAGSGD 500

Human   424 LTRAAREQRSQAEQLRRREH-------LLAQWE----LEVFERELTLLLQQVDRER-----PHVR 472
            :.|..|...:...:.||.:|       :....|    |.|.:.:....::..|:..     |.:.
Worm   501 INRKNRHSIAPETKARRLKHHKPKKADITGPTEVKHILSVQKDDKNFRVKTYDQSSTGGTLPRLN 565

Human   473 RRRGT--------FKRSKL-----RARDGGERISMPLDFKHRITVQASPGLDRRRNVFE---VGP 521
            .|:.|        |..|.|     .......|||.....:|:         ..:..:||   |.|
Worm   566 ERQSTLSLSSPDLFHISNLISGSNTVGHSAHRISRKNAIRHK---------KNQHRMFESPVVSP 621

Human   522 --GDSPTFPRF-RAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWA---WGPSSPKPGEAQNGR 580
              .||.||... .|.:::|           ....|....|.....||   |.....|.
Worm   622 TMDDSNTFSTIDNADEVDP-----------NHSKESKKGGTLSRAWAKLPWNKRDSKE------- 668

Human   581 RRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRAL 645
                        |.|:.:..||                        :.:...|::.:.:||....
Worm   669 ------------DHDERAVAGS------------------------ISSRSSSTTSSNRLITGQT 697

Human   646 LRGTALLASLGLGRDLQPPGGPGRERGES-------PTTPPTPTPAPCPTEPPPSPLICFSLKT- 702
            .||.:....|.:|         .|.|.:|       |.|......:|....|         :||
Worm   698 TRGASAAGLLEIG---------ARSRAQSTADGWEDPNTTKKHKVSPSDKRP---------VKTT 744

Human   703 -----------PDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSA-----PG 751
                       .|:|..||.|                             ||...:||     |.
Worm   745 NQTERYVKDLEKDTPLRPAQL-----------------------------PPTHRKSALDQTIPA 780

Human   752 TPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAP------------------ 798
            :|.:|.|     |:...|.||.||           |.:...|...||
Worm   781 SPNSPDS-----INNFHPMPLSSR-----------RTTANSSSDGAPCYDALVSHSYGAGHGHKN 829

Human   799 -----RRAPWTLFPDSDPFWDSPPANPF---------QGG 824
                 ...|  |||:....:|..|..||         |||
Worm   830 HFGLSDTIP--LFPEEPTHYDMGPGRPFGTNGRAIVNQGG 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K11	NP_002410.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	11..38
		SH3_MLK1-3	45..102	CDD:212992	19/56 (34%)
		STKc_MLK3	113..379	CDD:271049	106/326 (33%)
		STYKc	117..376	CDD:214568	105/319 (33%)
		Leucine-zipper 1	403..424		5/29 (17%)
		Leucine-zipper 2	438..459		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..643		14/108 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..847		44/225 (20%)
mlk-1	NP_001300151.1	SH3	75..124	CDD:302595	17/51 (33%)
		STYKc	153..450	CDD:214568	104/303 (34%)
		PKc_like	156..446	CDD:304357	104/296 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	173	1.000	Domainoid score	I2461
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	203	1.000	Inparanoid score	I2791
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001334
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860