DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP3K11 and map3k10

DIOPT Version :9

Sequence 1:	NP_002410.1	Gene:	MAP3K11 / 4296	HGNCID:	6850	Length:	847	Species:	Homo sapiens
Sequence 2:	XP_002938858.3	Gene:	map3k10 / 100488058	XenbaseID:	XB-GENE-920944	Length:	990	Species:	Xenopus tropicalis

Alignment Length:	964	Identity:	428/964 - (44%)
Similarity:	549/964 - (56%)	Gaps:	170/964 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    14 GSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAIS 78
            |.||                 ..::.|.:||:|.|:||||.:.::||.|.:||.||:||:|:.:|
Frog    23 GVWN-----------------EVQSYGVSNPLWMAVFDYEATAEEELTLHRGDLVEILSKDSTVS 70

Human    79 GDEGWWAGQVGGQVGIFPSNYV-------SRGGGPPPCEV---ASFQELRLEEVIGIGGFGKVYR 133
            ||||||.|::..:|||||||||       :..|.|..|.:   ..|:||.|||:||:|||||||:
Frog    71 GDEGWWTGKIKDKVGIFPSNYVVSDNKYTTLTGAPKQCPLPLEIEFEELNLEEIIGVGGFGKVYK 135

Human   134 GSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAG 198
            |.|||:.|||||.|.||||||:||||:|||||:||.||.||||||||.|||:.|:||||||||.|
Frog   136 GLWRGDEVAVKAVRHDPDEDINVTAENVRQEAKLFCMLCHPNIIALKGVCLKPPHLCLVMEYARG 200

Human   199 GPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTL 263
            |||.|||||::||.||||||||||||||:|||.||:||:|||||||:|||:|:.:|.||:.:|||
Frog   201 GPLHRALAGKKVPAHVLVNWAVQIARGMNYLHNEAIVPIIHRDLKSSNILILEKVEHDDLFNKTL 265

Human   264 KITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCL 328
            |||||||||||.|||:|||||||||||||||:.|.|||.|||||||||||||||||||||.||.|
Frog   266 KITDFGLAREWQKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDAL 330

Human   329 AVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFH 393
            |||||||:|||||||||||||||.:::..||..|||.||.|:.||:||..:|...:.:||.:|||
Frog   331 AVAYGVAMNKLTLPIPSTCPEPFVRILEACWDPDPHSRPSFSCILEQLTTIEQSAMFQMPLESFH 395

Human   394 SMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELT 458
            |:||.|:.|||.:|||||.|||||.||||||.|||.|||...|.|:|||..||:.|:::.||||.
Frog   396 SLQEDWRLEIQQMFDELRTKEKELRSREEELVRAAEEQRILEEMLKRREQELAEREIDIVERELN 460

Human   459 LLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVG--- 520
            :::.|:.:|:|.|::|:|.||:|:|:.:| |.|||:|..|:|:|||||||.||:.:......
Frog   461 IIMYQMYQEKPKVKKRKGNFKKSRLKLKD-GNRISLPSGFEHKITVQASPTLDKCKGQGSSSYSP 524

Human   521 PGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRR--- 582
            ||.....||.|||:|.|.:..:.|||.|..:.::.:...::....|||||.:..|...|..|
Frog   525 PGSPLIIPRLRAIRLTPVDGSKTWGRSSVLKKDEVNTSNKKKGRTWGPSSTQQKERAGGEERLKT 589

Human   583 ----------------------------SRMDEATWYLDSDDS---SPLGSPS--TPPALNG--N 612
                                        :.:.|...|.|:|.|   ||..:.|  |.||.:.  |
Frog   590 LGEGSKQWSSSAPNLGKSPKHTPISVGFASLTEMEEYADADGSVPQSPYSAQSYLTLPAQSDLRN 654

Human   613 PPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDL--------------QP 663
            .|..:.:...|....| :|||.|  .:..:..||...:|||::.||.||              |.
Frog   655 HPEDTSQAAAPSSDSP-KRGSQS--RRKSELVLLGCASLLAAVALGSDLSEMVPQEEKRKGIFQW 716

Human   664 PGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLL----DLGI------ 718
            .|...|.|..||:.|.:...   .:..|.|.:...||.:.....:...|:.    |:|:
Frog   717 AGRGPRRRTSSPSRPMSYGE---ESVIPSSSVTLISLSSISDCNSTRSLIRSDSDDIGLDSDTMS 778

Human   719 ------------------PVGQRSAKSPRRE-----------------EEPRGGTVSPPPGTSRS 748
                              |:.....:|.:|:                 .|.||...:|..|..|.
Frog   779 TGRVVKEDRGQQPNVGTNPLVDYKVESFKRDPKQSLTPTHVTAGRNNTNETRGHRRTPSDGAIRQ 843

Human   749 APGTPGTPRSPPLGLISRP--------RPSPLRSRIDPWSFVSAGP---------RPSPL---PS 793
            .  |.|..|||..|  |.|        .|||.....|| .||...|         ||:.|   |.
Frog   844 V--TQGHKRSPSDG--SAPFQCEPGSKEPSPFPRLPDP-HFVFPPPVRRKDTGVERPTSLEFAPR 903

Human   794 PQPA---PRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPE 844
            |:|:   ||..||.....|.....||.:    ||...|.:.:    |:.|.|.|
Frog   904 PRPSSSRPRMDPWKFVSLSQTHSSSPSS----GGGDACSSGS----AEGPRVAE 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K11	NP_002410.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	11..38		3/23 (13%)
		SH3_MLK1-3	45..102	CDD:212992	33/63 (52%)
		STKc_MLK3	113..379	CDD:271049	204/265 (77%)
		STYKc	117..376	CDD:214568	200/258 (78%)
		Leucine-zipper 1	403..424		16/20 (80%)
		Leucine-zipper 2	438..459		11/20 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..643		32/143 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..847		63/272 (23%)
map3k10	XP_002938858.3	SH3_MLK1-3	37..94	CDD:212992	33/56 (59%)
map3k10	XP_002938858.3	STKc_MLK2	124..381	CDD:271050	198/256 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D115270at2759
OrthoFinder	1	1.000	-	-		FOG0001334
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920