Protein Alignment niki and NEK9

DIOPT Version :10

• Sequence 1: NP_651293.1
• Gene: niki / 42959
• FlyBaseID: FBgn0045980
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: NP_001316166.1
• Gene: NEK9 / 91754
• HGNCID: 18591
• Length: 991
• Species: Homo sapiens
• Alignment Length: 740
• Identity: 225/740 - (30%)
• Similarity: 351/740 - (47%)
• Gaps: 138/740 - (18%)

  Fly    90 PRETGVGVAGPELANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVD 154
            || .|.|.|..|..:|..:||:|:|:||.|.||||..|...:|:|:::|:.||...|..|:||:.
Human    38 PR-AGGGAAEQEELHYIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIV 101

  Fly   155 VFSKLHHPNIVSYLGSFIKDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAIN 219
            :.:.|.|.||::|...|:.:.|||||:||.:||.|...|..::.|| |.|..::....||.||::
Human   102 ILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKL-FEEEMVVWYLFQIVSAVS 165

  Fly   220 YMHSENILHRDLKTANVFLNRRGIVKIGDFGISKIMNTKIH-AQTVLGTPYYFSPEMCEGKEYDN 283
            .:|...|||||:||.|:||.:..::|:||:|::|.:|::.. |:|::|||||.|||:|:|.:|:.
Human   166 CIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNF 230

  Fly   284 KSDIWALGCILGEMCCLKKTFAASNLSELVTKIMAG-NYTPVPSG-YTSGLRSLMSNLLQVEAPR 346
            ||||||:||::.|:..||:||.|:|...|..||:.| ....|.|. |:..|..::.:.|..:..:
Human   231 KSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQ 295

  Fly   347 RPTASEVLVYWIPLIFRSLGKNKGYSYEDDVGGPGSDQLTAPVPAAAYSNVSMELELPTAQTETK 411
            ||||.|       |:.|.|.:.:....|:.|     ..|.||......|.|
Human   296 RPTADE-------LLDRPLLRKRRREMEEKV-----TLLNAPTKRPRSSTV-------------- 334

  Fly   412 QLMIADTAAPHEILEKRSVLYQLKAFGTCFSMAPIQLPPKAVIV-------DVAMSDSHFVVVNE 469
                  |.||..::..|:....:...|.       ..|.|..::       .|...::||.||..
Human   335 ------TEAPIAVVTSRTSEVYVWGGGK-------STPQKLDVIKSGCSARQVCAGNTHFAVVTV 386

  Fly   470 DGSAYAW-----GEGTHGQLGLTALEAWKHYPSRMESVRNYHVVSACAGDGFTILVTQAGSLLSC 529
            :...|.|     |...|||||.....:::. |..:|.::...:.....||.||:.||..|.|.:.
Human   387 EKELYTWVNMQGGTKLHGQLGHGDKASYRQ-PKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAF 450

  Fly   530 GSNAHLALGQDE----------QRNY--HSPKLIARLADVRVEQVAAGLQHVLALSREGAVYVWG 582
            ||:.:..:|.|:          |.|:  .:|          ||||:.|..||:.|:|...||.||
Human   451 GSDYYGCMGVDKVAGPEVLEPMQLNFFLSNP----------VEQVSCGDNHVVVLTRNKEVYSWG 505

  Fly   583 TSTCGALGLG------------------NYQQQQK--FPQKILLSHVKTKPSKIYCGPDTSAVLF 627
               ||..|.|                  :|...||  .|:.:::..|:       ||.|.:.:|.
Human   506 ---CGEYGRGSLVSVHFFTGRLGLDSEEDYYTPQKVDVPKALIIVAVQ-------CGCDGTFLLT 560

  Fly   628 ANGELHVCGSNDYNKLGFQR----------------SAKITAFKKVQLPHKVTQACFSSTHSVFL 676
            .:|::..||.|::||||..:                :...|..|::.. :|:.......||:..:
Human   561 QSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSF-YKIRTIAPGKTHTAAI 624

  Fly   677 VEGGYVYTMGRNAEGQRGIRH------CNSVDHPTLVDSVKSRYIVKANCSDQCTIVASEDNIIT 735
            .|.|.:.|.|.|..||.|:.:      .|.:..|     :..:.:::.:|.|:.||.|::||.|.
Human   625 DERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGP-----LGGKQVIRVSCGDEFTIAATDDNHIF 684

  Fly   736 VWGT-RNGLPGIGSTNCGLGLQICT 759
            .||. .||...:..|....|..|||
Human   685 AWGNGGNGRLAMTPTERPHGSDICT 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	106/257 (41%)
		ATS1	433..749	CDD:444065	94/382 (25%)
NEK9	NP_001316166.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	18..43		3/5 (60%)
		STKc_Nek9	51..308	CDD:270860	108/264 (41%)
		ATS1	372..763	CDD:444065	96/365 (26%)
		RCC1 1	388..444		16/56 (29%)
		RCC1 2	445..498		17/62 (27%)
		RCC1 4	563..627		13/64 (20%)
		RCC1 5	628..680		14/56 (25%)
		RCC1 6	681..738		11/29 (38%)
		Interaction with NEK6. /evidence=ECO:0000269|PubMed:19001501	744..903
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	752..795
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	833..853
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	947..991