DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and AT1G69710

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_177129.2	Gene:	AT1G69710 / 843307	AraportID:	AT1G69710	Length:	1041	Species:	Arabidopsis thaliana

Alignment Length:	624	Identity:	126/624 - (20%)
Similarity:	209/624 - (33%)	Gaps:	183/624 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 MCEGKEYDNKSDIWALGCILGEMCCLKKTFAASNLSELVTKIMAGNY----------TPVPSGYT 329
            :|:.|:   ::::|.:|                 |..|:|::....:          ...|:.:.
plant   116 ICKDKD---EAEVWVVG-----------------LKSLITRVKVSKWKTTIKPEITSAECPTPHA 160

  Fly   330 SGLRSLMSNLLQVEAPRRPTASEVLVYWIPLIFRSLGKNKGYSYEDDV---GGPGSDQLT----- 386
            ..:...::.|.||..|...|:::.          .|||    .:.|.|   ..|.::..|
plant   161 RRVSPFVTILDQVIQPSNETSTQT----------RLGK----VFSDIVAITAPPSNNNQTEASGN 211

  Fly   387 -----APVPA-AAYSNVSMELELPTAQTETKQLMIADTAAPHEILEKRSVLYQLKAFGTCF---- 441
                 :|.|| ...||:......|...:.:..:..:...:.||         ...|.|..|
plant   212 LFCPFSPTPANVENSNLRFSTNDPFRLSLSSAVSTSSHGSYHE---------DFDALGDVFVWGE 267

  Fly   442 ---------------SMAPIQLPPKA----VIVD---VAMSDSHFVVVNEDGSAYAWGEGTHGQL 484
                           |.....|.|||    :::|   :|....|.|:|.:.|..::||||..|:|
plant   268 SISDGVLSGTGNSLNSTTEDALLPKALESTIVLDAQNIACGKCHAVLVTKQGEIFSWGEGKGGKL 332

  Fly   485 GLTALEAWKHYPSRMESVRNYHVVSACAGDGFTILVTQAGSLLSCGSNAHL-------------- 535
            | ..||.....|..:.|||.....|...||..|..:||:|.|.|.|...|.
plant   333 G-HGLETDAQKPKFISSVRGLGFKSLACGDFHTCAITQSGDLYSWGDGTHNVDLLGHGNESSCWI 396

  Fly   536 -----------------------------------------ALGQDEQRNYHSPKLIARLADVRV 559
                                                     |||..::|:...|:.:..|..:.|
plant   397 PKRVTGDLQGLYVSDVACGPWHTAVVASSGQLFTFGDGTFGALGHGDRRSTSVPREVESLIGLIV 461

  Fly   560 EQVAAGLQHVLAL-------------SREGAVYVWGTSTCGALGLGNYQQQQKFPQKILLSHVKT 611
            .:||.|:.|..|:             |..|.|:.||....|.||.|:  ...|...:.::|....
plant   462 TKVACGVWHTAAVVEVTNEASEAEVDSSRGQVFTWGDGEKGQLGHGD--NDTKLLPECVISLTNE 524

  Fly   612 KPSKIYCGPDTSAVLFANGELHVCGSNDYNKLGFQRSAKITAFKKVQ---LPHKVTQACFSSTHS 673
            ...::.||...:....:.|.::..||..|.:|| ..:||....::|:   :...|.:....|.|.
plant   525 NICQVACGHSLTVSRTSRGHVYTMGSTAYGQLG-NPTAKGNFPERVEGDIVEASVEEIACGSYHV 588

  Fly   674 VFLVEGGYVYTMGRNAEGQRGIRHCNSVDHPTLVDSVKSRYIVKANCSDQCTIV--------ASE 730
            ..|.....:||.|:...||.|..:..:...|.:|..::.:.:....|....|.|        .||
plant   589 AVLTSKSEIYTWGKGLNGQLGHGNVENKREPAVVGFLREKQVKAITCGSNFTAVICVHKWVPGSE 653

  Fly   731 DNIITVWGTRNGL----PGIGSTNCGLGL-QICTPNMEL 764
            .::..  |.||..    ......||||.. ::|:....|
plant   654 HSLCA--GCRNPFNFRRKRHNCYNCGLVFCKVCSSRKSL 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	13/93 (14%)
		S_TKc	105..354	CDD:214567	13/88 (15%)
		ATS1	445..747	CDD:227511	88/391 (23%)
AT1G69710	NP_177129.2	PH_PLC_plant-like	25..135	CDD:270171	6/38 (16%)
		RCC1_2	354..381	CDD:290274	10/26 (38%)
		RCC1	370..422	CDD:278826	5/51 (10%)
		RCC1	425..474	CDD:278826	11/48 (23%)
		RCC1	491..537	CDD:278826	12/47 (26%)
		RCC1	543..591	CDD:278826	12/48 (25%)
		RCC1	596..643	CDD:278826	10/46 (22%)
		FYVE	646..714	CDD:214499	11/47 (23%)
		DUF4200	838..936	CDD:290574
		BRX_N	896..>921	CDD:290432
		BRX	981..1035	CDD:285568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010