DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and NEK2

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_001327439.1	Gene:	NEK2 / 819641	AraportID:	AT3G04810	Length:	606	Species:	Arabidopsis thaliana

Alignment Length:	433	Identity:	123/433 - (28%)
Similarity:	204/433 - (47%)	Gaps:	77/433 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 LANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVS 166
            :.|||.:..:|:||||.|:|.|.|.:....|.|:|.|:..:...|..|..|:::.||:|:|.||.
plant     1 MENYEVLEQIGKGSFGSALLVRHKHEKKLYVLKKIRLARQTGRTRRSAHQEMELISKIHNPFIVE 65

  Fly   167 YLGSFI-KDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRD 230
            |..|:: |...:.|.:.|..||.:|:.|.:..| :||.|..:.....||..|:.|:|:.:|||||
plant    66 YKDSWVEKGCYVCIIIGYCKGGDMAEAIKKTNG-VHFTEEKLCKWLVQILLALEYLHANHILHRD 129

  Fly   231 LKTANVFLNRRGIVKIGDFGISKIMNTKIHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILG 295
            :|.:|:||.:...:::||||::|::.:...|.:|:|||.|..||:.....|.:|||||:|||.:.
plant   130 VKCSNIFLTKDQDIRLGDFGLAKVLTSDDLASSVVGTPSYMCPELLADIPYGSKSDIWSLGCCMY 194

  Fly   296 EMCCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVL------ 354
            ||..:|..|.|.::..|:.:|......|:|:.|::..|.|:.::|:.....||:|:|:|
plant   195 EMTAMKPAFKAFDMQGLINRINRSIVPPLPAQYSAAFRGLVKSMLRKNPELRPSAAELLRQPLLQ 259

  Fly   355 --VYWIPLIFRSLGKN--------------------------KGYSY---------EDDVGGPGS 382
              :..|.|.....|.|                          |.:|:         ||.|   .|
plant   260 PYIQKIHLKVNDPGSNVLPAQWPESESARRNSFPEQRRRPAGKSHSFGPSRFRGNLEDSV---SS 321

  Fly   383 DQLTAPVPAAAYSNVSMELELPT--------------AQTETKQLMIADTAAPHEILEKRSVLYQ 433
            .:.|.|    ||.|...:::|.|              |...::.:.:..:|:|....:.||.|.|
plant   322 IKKTVP----AYLNRERQVDLSTDASGDGTVVRRTSEASKSSRYVPVRASASPVRPRQPRSDLGQ 382

  Fly   434 LKAFGTCFSMAPIQL-----------PPKAVIVDVAMSDSHFV 465
            |.......:..|..|           |.|.:...:.:|.:.|:
plant   383 LPVSSQLKNRKPAALIRRASMPSSRKPAKEIKDSLYISKTSFL 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	92/263 (35%)
		S_TKc	105..354	CDD:214567	90/249 (36%)
		ATS1	445..747	CDD:227511	6/32 (19%)
NEK2	NP_001327439.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	177	1.000	Domainoid score	I1076
eggNOG	1	0.900	-	-		E1_KOG0589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	1	1.000	-	-		mtm947
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X891
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.810