DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and Nek2l1

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_345901.5	Gene:	Nek2l1 / 690209	RGDID:	1582899	Length:	443	Species:	Rattus norvegicus

Alignment Length:	472	Identity:	139/472 - (29%)
Similarity:	221/472 - (46%)	Gaps:	86/472 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 MPNRQESLLQLSVPRETGVGVAGPELANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSEL 141
            ||:|.|                     :||.:..:|.||:|.....||||||..:|:|:::...:
  Rat     1 MPSRVE---------------------DYEVLHSIGTGSYGRCQKIRRKSDGKILVWKELDYGSM 44

  Fly   142 SPPGRDLAMNEVDVFSKLHHPNIVSYLGSFI--KDNTLLIEMEYADGGTLAQIIAE-RQGKLHFP 203
            :...:.:.::||::..:|.|||||.|....|  .:.||.|.|||.:||.||.:|.: .:.:.:..
  Rat    45 TEVEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKDRQYLE 109

  Fly   204 ERYIIAVFEQISSAINYMH-----SENILHRDLKTANVFLNRRGIVKIGDFGISKIMNTKIH--- 260
            |.:::.|..|::.|:...|     ...:||||||.|||||:.:..||:||||:::|:|   |
  Rat   110 EEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDSKHNVKLGDFGLARILN---HDTS 171

  Fly   261 -AQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKKTFAASNLSELVTKIMAGNYTPV 324
             |:|.:|||||.|||......|:.|||||:|||:|.|:|.|...|.|.|..||..||..|.:..:
  Rat   172 FAKTFVGTPYYMSPEQISRLSYNEKSDIWSLGCLLYELCALMPPFTAFNQKELAGKIREGRFRRI 236

  Fly   325 PSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIPLIFRSLGKNKGYSYE---DDVGGPGSDQLT 386
            |..|:.||..|::.:|.::...||:..|:|.  .|||...:.:.:..:.|   ...|.|...|.:
  Rat   237 PYRYSDGLNDLITRMLNLKDYHRPSVEEILE--SPLIADLVAEEQRRNLERRGRRSGEPSKLQDS 299

  Fly   387 APVPAAAYSNVSMELELPTAQTE----------------TKQLMIADTAAPHEILEKRSVL--YQ 433
            :||.:        ||:|...|.:                .::|.|.:..|..::....|:|  |.
  Rat   300 SPVLS--------ELKLKERQLQDRERALRAREDSLEQKERELCIRERLAEDKLARAESLLKNYS 356

  Fly   434 LKAFGTCFSMA---PIQLPPKAVIVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHY 495
            |........:|   .:.||..|:...|     ||...:::.:..:  |.:..||..:.....|
  Rat   357 LLKEHRLLCLAGGSELDLPSSALKKKV-----HFHGESKENTTRS--ENSESQLAKSKCRDLK-- 412

  Fly   496 PSRMESVRNYHVVSACA 512
                   :..|....||
  Rat   413 -------KRLHAAQLCA 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	101/266 (38%)
		S_TKc	105..354	CDD:214567	100/260 (38%)
		ATS1	445..747	CDD:227511	13/68 (19%)
Nek2l1	XP_345901.5	STKc_Nek2	7..271	CDD:270857	102/268 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920