DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and Nek10

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_001381921.1	Gene:	Nek10 / 674895	MGIID:	2685128	Length:	1126	Species:	Mus musculus

Alignment Length:	292	Identity:	88/292 - (30%)
Similarity:	147/292 - (50%)	Gaps:	24/292 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 QMPNRQESLLQLSVPRETGVGVAGPELANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSE 140
            |:....||:.|...|.:        .:.:|..:..:|.|:||.....|::|..:.:..|::||.
Mouse   498 QIAENIESINQKKAPLK--------YIGDYAVLDHLGSGAFGCVYKVRKRSGQNLLAMKEVNLH- 553

  Fly   141 LSPP-GRDL---------AMNEVDVF-SKLHHPNIVSYLGSFIKDNTLLIEMEYADGGTLAQIIA 194
             :|. |:|.         .::|:.:. .:|:|||:|.|..:|::::.|.|.||..:|..|.:...
Mouse   554 -NPAFGKDKKDRDSSVKNIVSELTIIKEQLYHPNVVRYYKTFLENDRLYIVMELIEGAPLGEHFN 617

  Fly   195 ERQGK-LHFPERYIIAVFEQISSAINYMHSE-NILHRDLKTANVFLNRRGIVKIGDFGISKIMNT 257
            ..:.| .||.|..:..:|.|:..|:.|:|.| .|:||||...|:.|..:..|.:.|||::|....
Mouse   618 SLKEKHHHFSEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQE 682

  Fly   258 KIHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKKTFAASNLSELVTKIMAGNYT 322
            .....:::||..|..||:.:.:.|..|:|:||.||||.:|..|...|.::|:..|.|||:...|.
Mouse   683 SSKLTSMVGTILYSCPEVLKSEPYGEKADVWAAGCILYQMATLSPPFCSTNMLSLATKIVEAVYE 747

  Fly   323 PVPSG-YTSGLRSLMSNLLQVEAPRRPTASEV 353
            |||.| |:..:...:...|..:|..||...||
Mouse   748 PVPEGIYSEKVTDTIRRCLTPDAEARPDIVEV 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	83/264 (31%)
		S_TKc	105..354	CDD:214567	83/263 (32%)
		ATS1	445..747	CDD:227511
Nek10	NP_001381921.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
Nek10	NP_001381921.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..72
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810