DRSC/TRiP Functional Genomics Resources

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Protein Alignment niki and Herc6

DIOPT Version :9

Sequence 1:NP_651293.1 Gene:niki / 42959 FlyBaseID:FBgn0045980 Length:841 Species:Drosophila melanogaster
Sequence 2:NP_080268.1 Gene:Herc6 / 67138 MGIID:1914388 Length:1003 Species:Mus musculus


Alignment Length:399 Identity:94/399 - (23%)
Similarity:166/399 - (41%) Gaps:76/399 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   474 YAWGEGTHGQLGLTALEAWKHYPSRMES-VRNYHVVSACAGDGFTILVTQAGSLLSCGSNAHLAL 537
            ::|..|:             ..|.|::: .....::.|.:|:..::|:.....:.|||.|:...|
Mouse     3 FSWAAGS-------------RKPRRLKAGTSGIELLQAASGEHHSLLLFSNHRVYSCGDNSWGQL 54

  Fly   538 GQDEQRNYHSPKLIARLADVRVEQVAAGLQHVLALSREGAVYVWGTSTCGALGLGNYQQQQKFPQ 602
            ||...::...|:.|..|.|:.|:.|:.|.:|.:|:..:|.|:.||..:.|.||:|.:::....|.
Mouse    55 GQRRDQSTERPEPIQALNDLHVDLVSCGKEHSVAVCHKGKVFAWGAGSEGQLGIGEFKEISFMPT 119

  Fly   603 KI-LLSHVKTKPSKIYCGPDTSAVLFANGELHVCGSNDYNKLGFQRSAKITAFKKVQLPHKV--- 663
            || .|:.:|.  .::.||...|..|..:|.:...|.|...:||..::::..|     :|.||   
Mouse   120 KIKALAGIKI--IQVSCGHYHSLALSEDGHVFSWGRNSEGQLGLGKNSRSQA-----IPQKVKSL 177

  Fly   664 -----TQACFSSTHSVFLVEGGYVYTMGRNAEGQ---RGIRHCNSVDHPTLVDSVKSRYIVKANC 720
                 .|.....|||..|...|..:..|.|..||   .|.:....:..|..:.::|:..::..:|
Mouse   178 EGIPLAQVAAGGTHSFALSLTGTSFGWGSNRSGQLALSGNKVKEQIYKPHSIGALKNLSVIYISC 242

  Fly   721 SDQCTIVASED-NIITVWGTRNG---------------LPGIGSTNCGLGLQI-C---------- 758
            ..:.|.|.:|: .:.|..|..:|               :.|||    |...|| |          
Mouse   243 GYEHTAVLTEEGQVFTFGGNSSGQLQPSPRSGQRGPQLIEGIG----GRVSQIECASYHTIAYVY 303

  Fly   759 TPNMELELGNNTAAFTNFLASVYKSELILEPVDILALFSSKEQCDRGYYVQVHDVYPLAHSVLVL 823
            |....:.||...:..:|    ....|...|..||..|.::::..|    ::|.|::..||:..| 
Mouse   304 TTGQVVSLGRGPSHTSN----PTHQEAPAENSDITCLLAAEDLVD----IEVKDIFAGAHANFV- 359

  Fly   824 VDTTTPLIS 832
               ||..:|
Mouse   360 ---TTRRVS 365

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nikiNP_651293.1 STKc_Nek 104..359 CDD:270855
S_TKc 105..354 CDD:214567
ATS1 445..747 CDD:227511 70/301 (23%)
Herc6NP_080268.1 RCC1 1 40..91 16/50 (32%)
RCC1 40..89 CDD:278826 15/48 (31%)
RCC1 2 92..144 17/53 (32%)
RCC1 92..142 CDD:278826 16/51 (31%)
RCC1 145..195 CDD:278826 13/54 (24%)
RCC1 3 146..197 14/55 (25%)
RCC1_2 183..211 CDD:290274 8/27 (30%)
RCC1 4 199..252 11/52 (21%)
RCC1_2 237..266 CDD:290274 6/28 (21%)
RCC1 5 253..303 10/53 (19%)
RCC1 253..300 CDD:278826 10/50 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..281 2/19 (11%)
chaperonin_like <570..>652 CDD:295468
HECTc 658..999 CDD:238033
HECTc 682..999 CDD:214523
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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