DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and Nek7

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_067618.1	Gene:	Nek7 / 59125	MGIID:	1890645	Length:	302	Species:	Mus musculus

Alignment Length:	289	Identity:	103/289 - (35%)
Similarity:	161/289 - (55%)	Gaps:	30/289 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 ETGVGVAGP------------------ELANYEKVRVVGQGSFGIAILYRRKS--DGHQIVFKQI 136
            |...|:.||                  .|||:...:.:|:|.|  :.:||...  ||..:..|::
Mouse     3 EQSQGMQGPPVTQFQPQKALRPDMGYNTLANFRIEKKIGRGQF--SEVYRASCLLDGVPVALKKV 65

  Fly   137 NLSEL-SPPGRDLAMNEVDVFSKLHHPNIVSYLGSFIKDNTLLIEMEYADGGTLAQIIA--ERQG 198
            .:.:| ....|...:.|:|:..:|:|||::.|..|||:||.|.|.:|.||.|.|:::|.  ::|.
Mouse    66 QIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQK 130

  Fly   199 KLHFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIVKIGDFGISKIMNTK-IHAQ 262
            :| .|||.:...|.|:.||:::|||..::|||:|.||||:...|:||:||.|:.:..::| ..|.
Mouse   131 RL-IPERTVWKYFVQLCSALDHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAH 194

  Fly   263 TVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKKTFAAS--NLSELVTKIMAGNYTPVP 325
            :::|||||.|||......|:.|||||:|||:|.||..|:..|...  ||..|..||...:|.|:|
Mouse   195 SLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLP 259

  Fly   326 SG-YTSGLRSLMSNLLQVEAPRRPTASEV 353
            |. |:..||.|::..:..:..:||..:.|
Mouse   260 SDHYSEELRQLVNICINPDPEKRPDIAYV 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	97/259 (37%)
		S_TKc	105..354	CDD:214567	96/258 (37%)
		ATS1	445..747	CDD:227511
Nek7	NP_067618.1	NTE motif. /evidence=ECO:0000250	20..33		1/12 (8%)
		STKc_Nek6_7	33..294	CDD:270863	97/259 (37%)
		S_TKc	34..286	CDD:214567	95/254 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R445
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940