DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment niki and LOC567670

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_021324683.1	Gene:	LOC567670 / 567670	-ID:	-	Length:	4796	Species:	Danio rerio

Alignment Length:	987	Identity:	209/987 - (21%)
Similarity:	341/987 - (34%)	Gaps:	305/987 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 SLAEAMSSSKAQMPNRQESLLQLSVPRETGVGVAGPELANYE------------KVRVVGQGSFG 117
            |::|...||.|.|.:...|.:..|        ..|..||.::            :..:..|.|:.
Zfish  3402 SISEDAQSSDASMGSHLLSAVSWS--------AGGTLLAAFQNKLINIWTVNGTQAHIEAQSSWI 3458

  Fly   118 IAILYRRKSDGHQIVFKQINLSELSPP-----GR------------DLAMNEVDVF--SKLHHPN 163
            .|:.:.:.|....|   |...|:|:||     ||            ||.::..::.  .:...|.
Zfish  3459 TALSWVQTSTPFLI---QEASSQLNPPESLLVGRLDGSLCWLEVTEDLRVDRTELMHCHRKEAPQ 3520

  Fly   164 IVSYLGSFIKDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILH 228
            .:::..         ||..:|.|....:|:.............::..|.:..||:.:..:.::|
Zfish  3521 CLAWYS---------IEKPFAVGYPDGKILLGTAESYETEPPILLTAFPESVSALRWDPTGHLL- 3575

  Fly   229 RDLKTANVFLNRRGIVKI-GDFGISKI-MNTKIHAQTVLGTPYYFSPEMC--EGKEYDNKSDIWA 289
                   :.:.|..:||| |..|.:.: :::..|..||      .:.|.|  .|:..|.:. :.|
Zfish  3576 -------LSVGRSEVVKIWGRAGGAWVTLHSLFHTGTV------NTAEWCPLPGRGADPRL-MMA 3626

  Fly   290 LGCILG---------------------------EMCCLKKTFAAS--NLSELVTKIMAGNYTP-- 323
            :||..|                           :...:|:..|..  .||..:|.:...::.|
Zfish  3627 VGCQNGLLYVWTVPQGGANVSVPNFLTPSTSQDKSSAIKRGTAKCMFRLSGHITAVKTLSFCPSG 3691

  Fly   324 --VPSGYTSGLRSLMS----NLLQVEAPRRPTASEVLVYWIP----------------------- 359
              :.||...||.::.|    ::||...  ....|.|...|||
Zfish  3692 LALVSGGIGGLLNIWSLRDGSVLQTVV--TGMGSVVCTTWIPHIGVTACSGRSKDVLLIRCTSDW 3754

  Fly   360 -----------LIFRS---LGKNKG-----------------YSYEDDVGGPGSDQLTAPVPAAA 393
                       .:.||   ||.|:.                 |:||......| ||||......:
Zfish  3755 ISQNHILASCRSVLRSQGILGLNRAPCMAVFLERLPTLLQEQYNYEKSHVMAG-DQLTHSAFLQS 3818

  Fly   394 YSNVSMELELPTAQTETKQLMIADTAAPHE---------------------ILEKRSVLYQLKAF 437
            .|:::|.|.|       .||:......||.                     :....:.:...:||
Zfish  3819 LSSLAMGLFL-------DQLLCRQPKPPHHSGMGPVQDGAHGSFCPSEWNWLSTYSTTVKSAEAF 3876

  Fly   438 --GTCFS---MAPIQLPPKAVIVDVAMSDSHFVVVNED------------------GSAYAWGEG 479
              ||.|.   :||....|.|......:.:|.:..:.::                  ...|.||.|
Zfish  3877 ARGTPFPEAFIAPEFHHPGAAEFTKPLDNSKWTFMMDEQLMSWATSRPEDWQQGGKSEVYLWGNG 3941

  Fly   480 THGQLGLTALEAWKHYPSRMESVRNYHVVSACAGDGFTILVTQAGSLLSCGSNAHLALGQDEQRN 544
            .||||......|  ..|:...|:.....| .| |...|.||...|::|:.|..::..|||....:
Zfish  3942 RHGQLADAGTSA--SVPTLAPSLSQTQQV-VC-GQNCTFLVQANGTVLAVGEGSYGRLGQGNSDD 4002

  Fly   545 YHSPKLIARLADVRVEQVAAGL---QHVLALSREGAVYVWGTSTCGALGLGNYQQQQKFPQKI-- 604
            .::|.:|:.|....|.|:....   .|.|||:..|.|:.||....|.||.||.::|:: |::|
Zfish  4003 LYTPTIISALQGYVVTQLVTSYGSDGHSLALTETGEVFSWGDGDYGKLGHGNSERQRR-PKQIEG 4066

  Fly   605 LLSHVKTKPSKIYCGPDTSAVLFANGELHVCGSNDYNKLGFQRSA-------KITAFKKVQLPHK 662
            |...   :..::.||...|||:.|:|:|...||.|..:|| |||.       ::||..    .|.
Zfish  4067 LQGE---EVVQLACGFKHSAVVTADGKLFTFGSGDSGRLG-QRSTSNKMIPERVTALD----GHH 4123

  Fly   663 VTQACFSSTHSVFLVEGGY-VYTMGRNAEGQRGIRHCNSVDHPTLVDSVKSRYIVKANCSDQCTI 726
            :.|......|::.|...|. |:..|....|:.||..|....:|..|:|:.::.|.|..|....::
Zfish  4124 IGQVSCGINHTLVLSSDGLTVWAFGDGDYGKLGIGPCTVKCYPQKVESLCNKGIKKVGCGTHFSV 4188

  Fly   727 VASEDNIITVWGTRN--GLPGIGSTNCGLGLQICTPNMELELGNNTAAFTNFLASVYKSELILEP 789
            |.::|..|..:|...  |||.....|                 :|.......|..|:..::.:..
Zfish  4189 VLAKDGHIYTFGQERLIGLPDAMLKN-----------------HNRPQIIPALEGVFIEDIAVGC 4236

  Fly   790 VDILALFSSKEQCDRGYYVQVHDVYP----------LAHS----VLVLVDT-------------- 826
            ..||||.::            .|||.          |.||    ..:||.|
Zfish  4237 EHILALSNT------------GDVYAWGCNCEAQLGLGHSNPVKEPILVTTLQGKNIRQISAGRC 4289

  Fly   827 -----TTPLISS 833
                 |||.:|:
Zfish  4290 HSSAWTTPALST 4301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	57/326 (17%)
		S_TKc	105..354	CDD:214567	55/320 (17%)
		ATS1	445..747	CDD:227511	91/334 (27%)
LOC567670	XP_021324683.1	RCC1	371..724	CDD:332518
		SPRY_HERC1	1975..2131	CDD:293939
		UBA_HERC1	2682..2725	CDD:270584
		WD40	3351..3707	CDD:330360	62/339 (18%)
		WD40 repeat	3362..3400	CDD:293791
		WD40 repeat	3420..3451	CDD:293791	5/38 (13%)
		WD40 repeat	3458..3512	CDD:293791	12/56 (21%)
		WD40 repeat	3520..3557	CDD:293791	5/45 (11%)
		WD40 repeat	3563..3587	CDD:293791	6/31 (19%)
		WD40 repeat	3606..3653	CDD:293791	9/53 (17%)
		WD40 repeat	3682..3718	CDD:293791	8/35 (23%)
		RCC1	3869..4282	CDD:332518	114/454 (25%)
		HECTc	4408..4776	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010