DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment niki and hectd3

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_001070627.2	Gene:	hectd3 / 563189	ZFINID:	ZDB-GENE-031118-179	Length:	854	Species:	Danio rerio

Alignment Length:	663	Identity:	129/663 - (19%)
Similarity:	203/663 - (30%)	Gaps:	238/663 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 RETGVGVAGPELANYEKVRV----VGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPG------ 145
            |.|..|..|..|..|..|.:    :|:    :.:|....|  |..|. ::.:.|....|
Zfish   304 RVTVYGGEGDNLKKYSDVTIDDTLIGE----VCVLEDMTS--HLPVI-EVRIEECRDEGIDVRIR 361

  Fly   146 ---------RDLAMNEVDVFSKLHHPNIVSY-----------------LGSFIKDNTLLIEM--- 181
                     |||.:| .|||..   ||:|.|                 :..||   |||..:
Zfish   362 GLKIKSSCERDLGLN-ADVFQS---PNLVRYPRLEGTPPDVLYRRALVIQRFI---TLLDSLLPH 419

  Fly   182 -----EYADGGTLAQIIAERQGKLHFPERYII---AVFEQISSAINYMHSENILHRDLKTANVFL 238
                 :|: .||..||.:.:|..|....|..:   .:.:..:|..|:|            ..:::
Zfish   420 MVPAWDYS-LGTFNQIKSIKQFLLLSKRRSALITQCLKDSETSKPNFM------------PRLYI 471

  Fly   239 NRRGIVKIGDFGISKIMNTKIHA---QTVLGTPYYFSPEMCEG----KEYDNKSDI-WALGCILG 295
            |||..::..|       |..:..   ..||...|       ||    .:|:...|. |:......
Zfish   472 NRRLAMEHRD-------NPTLDVTCKNAVLTQVY-------EGLKPSDKYEKTLDYRWSARYDQW 522

  Fly   296 EMCCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIPL 360
            ..|                |.:|........|:...|..:...|.       |::||..   :||
Zfish   523 WEC----------------KFIAEGIIDQGGGFRDSLADMSEELC-------PSSSECP---LPL 561

  Fly   361 IFRSLGKNKGYSYEDDVGGP----------------------GSDQLTAPVPAAAYSN-----VS 398
            .|.:...|:|.....|...|                      |.|.|...:|...:..     ||
Zfish   562 PFFTRTSNQGAGEARDFYVPNPSCREFNKFEWIGQLMGAALRGKDFLVLALPGLVWKQLIGEAVS 626

  Fly   399 MELELPTAQTETKQLMIADTAAPHEILEKRSVLYQLKAFGTCFSMAPIQLPPKAVIVDVAMSDSH 463
            ...:.|...:...:|:   .|..|  ::|.:..::   ||            :.::....:||..
Zfish   627 WTKDFPAVDSVLVKLL---EAMDH--MDKETFDFK---FG------------QELVYTTPLSDGR 671

  Fly   464 FVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRMESVR---------NYHVVSACAGDGFTIL 519
            .|.:...||            |:..     .|..|:|.:|         |...:||... |...:
Zfish   672 LVELIPGGS------------GVVV-----RYEDRVEFIRLVQKARLEENREQISAMQA-GLVKV 718

  Fly   520 VTQAG-SLLS--------CGSNAHLALGQDEQRNYHSPKLIARLADVRVEQVAAGLQHVLALSRE 575
            |.||. .||:        ||         |.:....:.|.:.|..|  :||....:|
Zfish   719 VPQAVLDLLTWQEVEKKVCG---------DPEITVEALKRLTRYED--LEQTDVRVQ-------- 764

  Fly   576 GAVYVWGTSTCGALGLGNYQQQQKFPQKILLSHVKTKPSKIYCGPDT--SAVLFANGELHVCGSN 638
               |:|.       .|.|:..:.:......::.....|:.||..||.  |....|..:...|.|.
Zfish   765 ---YLWE-------ALMNFTNEDRSRFLRFVTGRSRLPAPIYIFPDKQGSETEDALPQSSTCSST 819

  Fly   639 DYNKLGFQRSAKI 651
            .|  |....|||:
Zfish   820 LY--LPKYPSAKV 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	58/309 (19%)
		S_TKc	105..354	CDD:214567	58/303 (19%)
		ATS1	445..747	CDD:227511	46/227 (20%)
hectd3	NP_001070627.2	APC10-HECTD3	231..366	CDD:176487	14/68 (21%)
		HECTc	523..842	CDD:214523	75/403 (19%)
		HECT	561..838	CDD:279026	65/339 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010