DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and herc4

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_005173092.1	Gene:	herc4 / 557513	ZFINID:	ZDB-GENE-070801-1	Length:	1052	Species:	Danio rerio

Alignment Length:	430	Identity:	111/430 - (25%)
Similarity:	174/430 - (40%)	Gaps:	86/430 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   454 IVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRMESVRNYHVVSACAGDGFTI 518
            ||.|:..::|.:.:|:.|..:|||.|:.|||||:.:|.....|..::|:...|:.....|...::
Zfish    86 IVAVSCGEAHTLALNDKGQVFAWGLGSDGQLGLSIVEDCLRVPRTVKSLSEVHITQVACGYWHSL 150

  Fly   519 LVTQAGSLLSCGSNAHLALGQDEQ-RNYHSPKLIARLADVRVEQVAAGLQHVLALSREGAVYVWG 582
            .:.:.|.:.|.|.|.:..||..:| ....||::|..|..:...|::||..|...|:..||::.||
Zfish   151 ALARGGEIFSWGQNKYGQLGLGQQGACVCSPQVIQSLQGIPFGQISAGGAHSFGLTLSGAIFGWG 215

  Fly   583 TSTCGALGLGNYQQQQKFPQKILLSHVKTKPSK----IYCGPDTSAVLFANGELHVCGSNDYNKL 643
            .:..|.||||: ...::||  :||   ||..|:    |.||.|.:|.|...|.:...|:..|.:|
Zfish   216 RNKFGQLGLGD-NDDRRFP--VLL---KTLRSQQVVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274

  Fly   644 GF-QRSAKITAFKKVQLPHKVTQ--ACFSSTHSVFLVEGGYVYTMGRNAEGQRGIRH-CNSVDHP 704
            |. ..:.::...|..:|...|..  ||.......|:...|.:.:.|....||.|.|. ||.:. |
Zfish   275 GHNSTNHEVNPRKVFELMGSVVSQIACGRQHTLAFIPSSGKIDSFGLGGNGQLGTRSTCNRIS-P 338

  Fly   705 TLV---------------DSVKSRYIVKANCS--DQ--CTIVASEDN------------------ 732
            |.|               ...:..|.||...:  ||  .....|||:
Zfish   339 TPVKGCWRAHADPVAMDHSEAERSYCVKRIYAGGDQSFAHYALSEDDGPPLDVRITRPAGQIYTL 403

  Fly   733 ---IITVWGTRNGLPGIGSTNCGLGLQICTPNMELELGNNTAAFTN--FLASVYKSELILEPVDI 792
               :|..|           .|.|||........|::|..::|:..|  ||:|.....
Zfish   404 STELIQKW-----------LNHGLGRIPAEITDEIDLVFSSASCLNGSFLSSSNPDH-------- 449

  Fly   793 LALFSSKEQCDRGYYVQVHDVYPLAHSVLVLVDTTTPLIS 832
               :|:..:|..   |.::....|.|.   |:.|..|.||
Zfish   450 ---YSTSSKCSG---VDINTARLLFHK---LIQTDHPQIS 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855
		S_TKc	105..354	CDD:214567
		ATS1	445..747	CDD:227511	90/341 (26%)
herc4	XP_005173092.1	RCC1	3..49	CDD:278826
		RCC1	52..99	CDD:278826	4/12 (33%)
		RCC1	102..152	CDD:278826	15/49 (31%)
		RCC1	156..205	CDD:278826	15/48 (31%)
		RCC1	208..257	CDD:278826	21/54 (39%)
		RCC1	260..308	CDD:278826	10/47 (21%)
		RCC1	313..377	CDD:278826	16/64 (25%)
		HECTc	704..1049	CDD:238033
		HECTc	730..1049	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920