Protein Alignment niki and si:ch211-285c6.3

DIOPT Version :10

• Sequence 1: NP_651293.1
• Gene: niki / 42959
• FlyBaseID: FBgn0045980
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: XP_685228.2
• Gene: si:ch211-285c6.3 / 557131
• ZFINID: ZDB-GENE-040724-148
• Length: 543
• Species: Danio rerio
• Alignment Length: 484
• Identity: 120/484 - (24%)
• Similarity: 201/484 - (41%)
• Gaps: 122/484 - (25%)

  Fly   124 RKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLH--HPNIVSYLGSFIKD-NTLLIEMEYAD 185
            :...|.|.|.|:::..:           |.||...||  ||:||.: ...|:| :.|.:.:::.:
Zfish    26 KNEKGDQFVVKKLSTRQ-----------EKDVNFLLHLDHPHIVHH-KEIIRDGDDLYLVLDHCE 78

  Fly   186 GGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIVKIGDFG 250
            ||.||:.|.:..|:  |.|:.|:....||..|:.::|.:.|||:||:..::.....|.:::|:|
Zfish    79 GGDLAEKIKQATGQ--FSEKEILDWTVQICMALKHLHDQQILHKDLQPKSLLFTACGTIRLGEF- 140

  Fly   251 ISKIMNTKIHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKKTFAASNLSELVTK 315
             .|.......|:|  .:..||:||......|..||:||.||||:.|||.|||.|::.|..|::.|
Zfish   141 -DKWFTDVQTAET--ESLAYFAPENLHDTSYYEKSEIWRLGCIICEMCTLKKAFSSGNTDEIIKK 202

  Fly   316 IMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIPLIFRSLGKNKGYSYEDDVGGP 380
            |...:|..:|:.::..|:.|:.:.|||....||:.||:|:.  |.|.:.|.:....:.|:
Zfish   203 ICRSSYEHLPTNFSEDLQELIKDTLQVNPADRPSVSEILMR--PFIIKHLREMSKKTVEE----- 260

  Fly   381 GSDQLTAPVPAAAYSNVSMELELPTAQTETKQLMIADTAAPHEILEKRSVLYQLKAFGTCFSMAP 445
                          .|.|:: ||.|         :||.      |||
Zfish   261 --------------LNKSLD-ELRT---------LADD------LEK------------------ 277

  Fly   446 IQLPPKAVIVDVAMSDSHF--VVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRMESVRNYHVV 508
                            .||  .|.:..|.......|....:||              ::..:.:.
Zfish   278 ----------------IHFNTTVGSLSGGVIGLVGGILSVVGL--------------ALTPFTLG 312

  Fly   509 SACAGDGFTILVTQAGSLLSCGSNAHLALGQDEQRNYHSPKLIARLADVRVEQVAAGLQHV---- 569
            ::....|..|.|..||.:.|..||....:.|  :.|..:.|:|..|...::...:..:|::
Zfish   313 ASLIVTGVGIGVATAGGVASGVSNVTKMVNQ--RSNRQNIKMIITLFQEKINSTSCCIQNIKIAV 375

  Fly   570 ------LALSREGAVYVWGTSTCGALGLG 592
                  |:.:||  .::.|||....||.|
Zfish   376 ETLKKELSTNRE--TFLNGTSAGARLGRG 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	76/237 (32%)
		ATS1	433..749	CDD:444065	30/172 (17%)
si:ch211-285c6.3	XP_685228.2	Protein Kinases, catalytic domain	23..246	CDD:473864	77/239 (32%)
		ApoL	<260..>347	CDD:461657	26/171 (15%)