DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and nek1

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_009292952.1	Gene:	nek1 / 556002	ZFINID:	ZDB-GENE-040730-1	Length:	1413	Species:	Danio rerio

Alignment Length:	373	Identity:	136/373 - (36%)
Similarity:	203/373 - (54%)	Gaps:	52/373 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 YEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVSYLG 169
            ||:::.:|:||||.|||.:.::||.|.|.|:|.:|.:|...|..:..||.|.:.:.|||||.|..
Zfish     4 YERLKKIGEGSFGKAILVKSRTDGRQYVIKEIGISRMSNKERQESRKEVAVLANMSHPNIVQYKE 68

  Fly   170 SFIKDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDLKTA 234
            ||.:...|.|.|:|.:||.|.:.|..::|.| |||..|:..|.||..|:.::|...|||||:|:.
Zfish    69 SFEESGCLYIVMDYCEGGDLFKKINNQRGSL-FPEEQILDWFVQICLALKHVHDRKILHRDIKSQ 132

  Fly   235 NVFLNRRGIVKIGDFGISKIMNTKIH-AQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMC 298
            |:||.:.|.|::|||||::::|:.:. |:|.:|||||.|||:||.|.|:||||||||||:|.|||
Zfish   133 NIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYEMC 197

  Fly   299 CLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIPLIFR 363
            .||..|.|.|:..||.||:.|:|.||...|:..||||::.|.:.....||:.|.:|..  |.:.|
Zfish   198 TLKHAFEAGNMKNLVLKIIRGSYPPVSIHYSPDLRSLLAQLFKRNPRERPSVSTILDK--PFLAR 260

  Fly   364 SLGK-------NKGYSY----------------EDDVGGP----GSDQLTAP------------- 388
            .:.|       .:.:|:                :....||    .:.::|.|
Zfish   261 RIHKFLSPQLIAQEFSHSIHLQPKMSVAHAAPAKRPAPGPIPITSAQKITKPAAKYGVPLTVRRP 325

  Fly   389 ------VPAAAYSNVSMELELPTAQTETKQLMIADTAAPHE--ILEKR 428
                  ||.||...|.::...|.|..:.:...:.:....||  :.:||
Zfish   326 SEVARKVPDAAKKPVKLKQAPPPAAVQRRVSRVEEERRKHEEGVRKKR 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	117/254 (46%)
		S_TKc	105..354	CDD:214567	116/249 (47%)
		ATS1	445..747	CDD:227511
nek1	XP_009292952.1	STKc_Nek1	3..258	CDD:270858	118/256 (46%)
nek1	XP_009292952.1	S_TKc	4..258	CDD:214567	118/256 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	237	1.000	Domainoid score	I2252
eggNOG	1	0.900	-	-		E1_KOG0589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820