DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment niki and rcbtb1

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_001017352.2	Gene:	rcbtb1 / 550106	XenbaseID:	XB-GENE-987316	Length:	599	Species:	Xenopus tropicalis

Alignment Length:	497	Identity:	107/497 - (21%)
Similarity:	181/497 - (36%)	Gaps:	101/497 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 RSLGKNKGY------SYEDDVGGPGSDQLTAPVPAAAYSNVSM---------ELELPTAQTETKQ 412
            ||:.:::.:      .:|:....|...|:..||.|....|..|         .|..|......:|
Frog    28 RSIRESRCFRVASITEWEETTDSPLRQQICKPVTACTKPNADMVDFGKWPLFALLSPQDLASIRQ 92

  Fly   413 LMIADTAAPHEILEKRSVLYQLKAFG----TCFSMAPIQ--LPPKAV-------IVDVAM-SDSH 463
            ..|..:||...|...::  .::..||    .|......|  :.|:.:       |||::. |..|
Frog    93 ACIFGSAANEAIYTTQN--NEVFVFGMNSSNCLGTGDNQSTIIPRRLDVLCGKRIVDLSYGSGPH 155

  Fly   464 FVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRMESVRNYHVVSACAGDGFTILVTQAGSLLS 528
            .:|.||||..|:||...:.|||            ...:::....|..|.
Frog   156 ILVCNEDGEVYSWGHNGYSQLG------------NGNAIQGVAPVQVCM---------------- 192

  Fly   529 CGSNAHLALGQDEQRNYHSPKLIARLADVRVEQVAAGLQHVLALSREGAVYVWGTSTCGALGLGN 593
                                :|:|:    :|.|||.|..|.:||:.:|.|:.||.:.||.:|.|.
Frog   193 --------------------ELLAK----KVIQVACGSHHSMALTSDGEVFCWGYNNCGQVGSGT 233

  Fly   594 YQQQQKFPQKILLSHVKTKPSKIYCGPDTSAVLFANGELHVCGSNDYNKLGFQRSAKITAFKKVQ 658
             ...|..|:::..:........|..|..:|..:..||.::..|.|...:||...:.......::.
Frog   234 -TANQSVPRRVSATLQSKVVVSIAAGQSSSMAVTDNGHVYCWGYNGTGQLGIGNTGNQLMPCRLV 297

  Fly   659 LPHKV--TQACFSSTHSVFLVEGGYVYTMGRNAEGQRGIRHCNSVDHPTLVDSVKSRYIVKANCS 721
            ..|.|  .|......|::.|.:.|.:|..|.|:.||.||.:.::...|..|.:.:....|.|..|
Frog   298 FAHPVCIIQVVLGYAHTLALSDQGVLYAWGANSHGQLGIGNKSNQTAPVKVGTNERMVEVTACHS 362

  Fly   722 DQCTIVASEDNIITVWGTRNG----LPGIGSTNCGLGLQICTPNMELELGNNTAAFTNFLASVYK 782
            ...:...|:...:.:||...|    .|.:...:|...:..|.        :|......|| ||..
Frog   363 TNISAAKSQSGQVYMWGLCRGQSLLSPHLTHFSCTDDVFACF--------SNPPVMWRFL-SVEH 418

  Fly   783 SELILEPVDILALFSSKEQCDRGYYVQVHDVYPLAHSVLVLV 824
            .:.:.....:...|.|:|..|..:.|...|:|  .|..::.:
Frog   419 EDFLTVAESLKKEFDSEETSDLKFRVDGKDIY--VHKAVLKI 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855
		S_TKc	105..354	CDD:214567
		ATS1	445..747	CDD:227511	72/317 (23%)
rcbtb1	NP_001017352.2	RCC1	111..153	CDD:278826	8/41 (20%)
		RCC1	162..212	CDD:278826	18/101 (18%)
		RCC1	215..265	CDD:278826	13/50 (26%)
		RCC1	268..317	CDD:278826	10/48 (21%)
		RCC1_2	304..333	CDD:290274	7/28 (25%)
		RCC1	321..362	CDD:278826	12/40 (30%)
		BTB	428..532	CDD:279045	8/33 (24%)
		BTB	439..535	CDD:197585	5/22 (23%)
		SPOP_C_like	535..591	CDD:269810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010