DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and HERC6

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_005263140.1	Gene:	HERC6 / 55008	HGNCID:	26072	Length:	1034	Species:	Homo sapiens

Alignment Length:	378	Identity:	93/378 - (24%)
Similarity:	159/378 - (42%)	Gaps:	66/378 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   378 GGPGSDQLTAPVPAAAYSNVSMELELPTAQTETKQLMIADTAAPHEIL----EKRSVLYQLKA-- 436
            |.||::.|.|                  |..|...|::...   |.:|    ..|..|.:..|
Human    19 GSPGAELLQA------------------ASGERHSLLLLTN---HRVLSCGDNSRGQLGRRGAQR 62

  Fly   437 ------FGTCFSMAPIQLPPKA---VIVD-VAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEA 491
                  .|.||.:.|.: |.:|   :||| |:....|.:.|...|..:|||.|:.||||:...:.
Human    63 GELPVVVGGCFVLFPKE-PIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKE 126

  Fly   492 WKHYPSRMESVRNYHVVSACAGDGFTILVTQAGSLLSCGSNAH--LALGQDEQRNYHSPKLIARL 554
            ....|.::.::.:..::....|...::.:::...:.|.|.|:|  |.||: |..:..||:.:..|
Human   127 ISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGK-EFPSQASPQRVRSL 190

  Fly   555 ADVRVEQVAAGLQHVLALSREGAVYVWGTSTCGALGLG--NYQQQQKFPQKI-LLSHVKTKPSKI 616
            ..:.:.|||||..|..|||..|..:.||:::.|.|.|.  |...|...|..: .|.::    ..:
Human   191 EGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNL----GVV 251

  Fly   617 Y--CGPDTSAVLFANGELHVCGSNDYNKLGFQRSAKITAFKKVQ-LPHKVTQACFSSTHSVFLVE 678
            |  ||...:|||..:|::...|.|...:||:..:.:....:.|: :...|:|....|.|::
Human   252 YISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVSQIDCGSYHTL---- 312

  Fly   679 GGYVYTMGRNAEGQRGIRHCNSVDHPTLVDSVKSRYIVKANCSDQCTIVASED 731
             .||:|.|:......|....:...||..:..         |....| ::::||
Human   313 -AYVHTTGQVVSFGHGPSDTSKPTHPEALTE---------NFDISC-LISAED 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855
		S_TKc	105..354	CDD:214567
		ATS1	445..747	CDD:227511	77/299 (26%)
HERC6	XP_005263140.1	RCC1_2	27..54	CDD:290274	7/47 (15%)
		RCC1_2	89..118	CDD:290274	10/28 (36%)
		RCC1	105..155	CDD:278826	11/49 (22%)
		RCC1	158..208	CDD:278826	17/50 (34%)
		RCC1	215..263	CDD:278826	13/51 (25%)
		RCC1_2	250..279	CDD:290274	9/28 (32%)
		RCC1	266..313	CDD:278826	10/51 (20%)
		HECTc	684..1026	CDD:238033
		HECTc	711..1026	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920