DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and NEK2

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_002488.1	Gene:	NEK2 / 4751	HGNCID:	7745	Length:	445	Species:	Homo sapiens

Alignment Length:	370	Identity:	122/370 - (32%)
Similarity:	191/370 - (51%)	Gaps:	58/370 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 MPNRQESLLQLSVPRETGVGVAGPELANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSEL 141
            ||:|.|                     :||.:..:|.||:|.....||||||..:|:|:::...:
Human     1 MPSRAE---------------------DYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSM 44

  Fly   142 SPPGRDLAMNEVDVFSKLHHPNIVSYLGSFI--KDNTLLIEMEYADGGTLAQIIA----ERQGKL 200
            :...:.:.::||::..:|.|||||.|....|  .:.||.|.|||.:||.||.:|.    |||
Human    45 TEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQ--- 106

  Fly   201 HFPERYIIAVFEQISSAINYMH-----SENILHRDLKTANVFLNRRGIVKIGDFGISKIMNTKIH 260
            :..|.:::.|..|::.|:...|     ...:||||||.|||||:.:..||:||||:::|:|   |
Human   107 YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILN---H 168

  Fly   261 ----AQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKKTFAASNLSELVTKIMAGNY 321
                |:|.:|||||.|||......|:.|||||:|||:|.|:|.|...|.|.:..||..||..|.:
Human   169 DTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKF 233

  Fly   322 TPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIPLIFRSLGKNKGYSYE---DDVGGPGSD 383
            ..:|..|:..|..:::.:|.::...||:..|:|..  |||...:...:..:.|   ..:|.|...
Human   234 RRIPYRYSDELNEIITRMLNLKDYHRPSVEEILEN--PLIADLVADEQRRNLERRGRQLGEPEKS 296

  Fly   384 QLTAPVPAAAYSNVSMELELPTAQTETKQLMIADTAAPHEILEKR 428
            |.::||.:        ||:|...|.:.::..:   .|..|.||::
Human   297 QDSSPVLS--------ELKLKEIQLQERERAL---KAREERLEQK 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	101/269 (38%)
		S_TKc	105..354	CDD:214567	100/263 (38%)
		ATS1	445..747	CDD:227511
NEK2	NP_002488.1	STKc_Nek2	7..271	CDD:270857	102/271 (38%)
		Interaction with PCNT. /evidence=ECO:0000269\|PubMed:20599736	264..445		19/80 (24%)
		Interaction with CEP85. /evidence=ECO:0000269\|PubMed:26220856	301..445		10/41 (24%)
		Leucine-zipper	306..334		7/28 (25%)
		Necessary for interaction with MAD1L1. /evidence=ECO:0000269\|PubMed:14978040	329..445		0/2 (0%)
		Required for microtubule binding and for localization to the centrosomes	333..370
		Interaction with SAV1 and STK3/MST2. /evidence=ECO:0000269\|PubMed:21076410	403..439
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R445
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950