DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment niki and ca

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_001287593.1	Gene:	ca / 43518	FlyBaseID:	FBgn0000247	Length:	1961	Species:	Drosophila melanogaster

Alignment Length:	712	Identity:	150/712 - (21%)
Similarity:	231/712 - (32%)	Gaps:	231/712 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 LANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSK--LHHPNI 164
            |..|.|.||.     .|....:....||.....|::.         :|:....:...  |.||.:
  Fly   802 LLTYNKARVK-----PIRTALKLAMYGHTYALMQLSA---------MALKSTYLLRSRYLGHPLL 852

  Fly   165 VSYLGSFIKDNTLLIEMEYADGGTLAQIIAERQGKLH-----FPERYIIAVFEQIS----SAINY 220
            ...||          ::.|.....:..|:.|:..:..     |...|...|.|.||    |..:.
  Fly   853 KGILG----------DITYRHSEDVRVILPEKHEEEDVNSGVFCSDYHYGVDESISALQMSPSSQ 907

  Fly   221 MHSENILHRDLKTANVFLNRRGIVKIGDFGISKIMNTKIHAQTVLGTPYYFSPEMCEGKEYDNKS 285
            .|..|:|.  :..|...:|.:..:.:.:|   .:.|:|.|....       |..:|:       |
  Fly   908 FHLANLLL--ITLAEKAVNDKNYIPLWNF---LVTNSKYHTNMT-------SIVLCQ-------S 953

  Fly   286 DIWALGCILGEM--CCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLR----SLMSNLLQVEA 344
            .:::...||.::  .|| .||.|      :..::|..:     |:.:.|.    :|..|:.....
  Fly   954 GLFSSAIILAKIRGVCL-DTFNA------LISVVAQEF-----GWYNELNVCLYNLSENIFLETI 1006

  Fly   345 PRRPTAS--------EVLVYWIPLIFRSLGKNKGYSYEDDVGGPGSDQLTAPVPAAAYSNVSMEL 401
            ...|..|        |.|.:..|.:.:.|.|                ||. |...|....||...
  Fly  1007 TYLPHVSMDYFAFIQEKLHHIRPCVLQRLSK----------------QLN-PFSPALRPIVSHNS 1054

  Fly   402 ELPTAQTETKQLMIADTAAPHEILEKRSVLYQLKAFGTCFSMAPIQLPPKAVIVDV--------- 457
            :...:.....||                       |..|.|:....|   ||::.:
  Fly  1055 DCAMSNDNNPQL-----------------------FEFCKSLIETYL---AVLIHMESQRVKYDS 1093

  Fly   458 ---AMS-------DSHFVVVNE----------------DGSAYAWG-----------------EG 479
               |:|       |:.|.:.:.                ||:||.||                 |.
  Fly  1094 IVNALSNFRINYEDNQFAIESSRFKPISAGCAYCACVVDGTAYFWGSSGIPSYYSAQKSTEPPEP 1158

  Fly   480 THGQLGLTALEAWKHYPSRMESVRNYHVVSACAGDGFTILVTQAGSLLSCGSN--AHLALGQDEQ 542
            .|....|..|           |..|..|.:...|...|:::|..| |.|.|:|  ..|.:|:..|
  Fly  1159 AHAVKSLDLL-----------SQLNLQVHAIKCGRQHTLILTNNG-LYSLGNNNLCQLGIGRHMQ 1211

  Fly   543 RNYHSPKLIARLADVRVEQVAAGLQHVLALSREGAVYVWGTSTCGALGLG---NYQQQQ-----K 599
            ... .|.|:..|..:.:..:.||..|..|:: :|.:|:||....|.||.|   |....|     |
  Fly  1212 MAL-QPMLVTALDGMNITMLEAGQYHNAAVA-DGKLYMWGWGIYGQLGQGSCENIATPQLVSFFK 1274

  Fly   600 FPQKIL---LSHVKTKPSKIYCGPDTSAVLFAN---GELHVCGSNDYNKLGFQRSAKITAFKKVQ 658
            | :|||   |.|..|   .:.||...|. :.||   .||.|.|||.:.:||...|..  ...|..
  Fly  1275 F-KKILQISLGHAHT---LVLCGAPNSH-MEANHCGNELFVFGSNHFGQLGTGNSDH--GDTKTN 1332

  Fly   659 LPHK--VTQACFSSTHSVFLV-----EGGYVYTMGRNAEGQRGIRHCNSVDHPTLVDSVKSR 713
            ||.:  |........|:.|..     |...::|.|.:.:..|            |.:.:|.|
  Fly  1333 LPVRLEVGDCSLRLIHTKFFTNLAVDEQDRLFTWGSSPQALR------------LANQIKRR 1382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	52/279 (19%)
		S_TKc	105..354	CDD:214567	51/273 (19%)
		ATS1	445..747	CDD:227511	83/344 (24%)
ca	NP_001287593.1	ATS1	1158..1588	CDD:227511	69/258 (27%)
		RCC1_2	1175..1200	CDD:290274	8/25 (32%)
		RCC1	1193..1240	CDD:278826	13/47 (28%)
		RCC1	1242..1291	CDD:278826	18/52 (35%)
		RCC1_2	1503..1532	CDD:290274
		RCC1	1522..1568	CDD:278826
		RCC1_2	1558..1584	CDD:290274
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.010