DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and Rpgr

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_038955861.1	Gene:	Rpgr / 367733	RGDID:	1560136	Length:	1380	Species:	Rattus norvegicus

Alignment Length:	386	Identity:	98/386 - (25%)
Similarity:	168/386 - (43%)	Gaps:	66/386 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   387 APVPAAAYSNVSMELELPTAQTETKQLMIADTAAPHEILEKRSVLYQLKAFG-TCFSMAPIQLPP 450
            |.:|.||:.         .|:.|:   ::.||.|             :..|| |.|:.   .:|.
  Rat    30 AQIPFAAFG---------MAEPES---LVPDTGA-------------VFTFGKTKFAE---NIPS 66

  Fly   451 K-----AVIVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRMESVRNYHVVSA 510
            |     .|.:.::..|.|..:|..:...|.:|....|||||.:..|... |:.:::::...|..|
  Rat    67 KFWFKNDVPICLSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKSAISK-PTCIKALKPEKVKLA 130

  Fly   511 CAGDGFTILVTQAGSLLSCGSN--AHLALGQDEQRN------YHSPKLIARLADVRVEQVAAGLQ 567
            ..|...|::.|..|.:.:.|.|  ..|.||..:.|:      :.:|      :|: ::|::||..
  Rat   131 ACGRNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIGFFTP------SDI-IKQLSAGAN 188

  Fly   568 HVLALSREGAVYVWGTSTCGALGLGNYQQQQKFPQKILLSHVKT--KP-SKIYCGPDTSAVLFAN 629
            ...||:.:|.:::||.::.|.:||.|       ...:.:.|..|  || |.|.||...||.:..:
  Rat   189 TSAALTEDGKLFMWGDNSEGQIGLKN-------KSNVCIPHEVTVGKPISWISCGYYHSAFVTTD 246

  Fly   630 GELHVCGSNDYNKLGFQRSAKI---TAFKKVQLPHKVTQACFSSTHSVFLVEGGYVYTMGRNAEG 691
            |||:..|..:..|||......|   :..:.:.:|.||.|......|:|.|.| ..||..|....|
  Rat   247 GELYTFGEPENGKLGLPNQLLINHRSPQRVLGIPDKVIQVACGGGHTVVLTE-KVVYAFGLGQFG 310

  Fly   692 QRGI-RHCNSVDHPTLVDSVKSRYIVKANCSDQCTIVASEDNIITVWGT-RNGLPGIGSTN 750
            |.|: ........|.::|.:|.:.|...:|.:..|.:.::..::..:|. |:|..|:|..|
  Rat   311 QLGLGTFLFETSEPKIIDRIKDQKISHISCGENHTALMTDIGLMYTFGDGRHGKLGLGMEN 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855
		S_TKc	105..354	CDD:214567
		ATS1	445..747	CDD:227511	83/322 (26%)
Rpgr	XP_038955861.1	ATS1	<78..368	CDD:227511	80/305 (26%)
		RCC1	352..398	CDD:395335	6/20 (30%)
		MDN1	<625..904	CDD:227596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010