DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and rcbtb1

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_956285.1	Gene:	rcbtb1 / 336007	ZFINID:	ZDB-GENE-030131-7951	Length:	531	Species:	Danio rerio

Alignment Length:	389	Identity:	99/389 - (25%)
Similarity:	160/389 - (41%)	Gaps:	42/389 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 SDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRMESVRNYHVVSACAGDG-FTILVTQA 523
            |.:..:.:..|...|..|......|| |........|.:::.:....::|...|.| ..:|||:.
Zfish    30 SANEAIYITHDDEVYVLGLNCSNCLG-TGDSQSTIAPKKLDCLSGKKLISLSYGSGPHVLLVTED 93

  Fly   524 GSLLSCGSNAHLALGQDEQRNYHSPKLIA-RLADVRVEQVAAGLQHVLALSREGAVYVWGTSTCG 587
            |.|.:.|.|.:..||........||.|:: .|...||.:|:.|..|.|||:.||.|:.||.:.||
Zfish    94 GELYAWGHNGYSQLGNGTTNQGVSPILVSTNLQGKRVTEVSCGSHHSLALTHEGEVFAWGYNNCG 158

  Fly   588 ALGLGNYQQQQKFPQKILLSHVKTKPSKIYCGPDTSAVLFANGELHVCGSNDYNKLGFQRSA-KI 651
            .:|.|: ...|..|:|:...........|.||..:|..:..|||::..|.|...:||...:. ::
Zfish   159 QVGSGS-TANQPTPRKVSNCLQNKVIVNIACGQTSSMAVTDNGEVYGWGYNGNGQLGLGNNGNQL 222

  Fly   652 TAFKKVQLP-HKVTQACFSSTHSVFLVEGGYVYTMGRNAEGQRGIRHCNSVDHPTLVDSVKSRYI 715
            |..:.:.|. ..|.|......||:.|.:.|.:|..|.|..||.|..:.::...|..|.:.|.|.:
Zfish   223 TPCRLIALQGFCVLQIASGYAHSLALTDEGLLYAWGANTYGQLGTGNKSNQLSPVQVMTEKERIV 287

  Fly   716 VKANCSDQCTIVA-SEDNIITVWGTRNGLPGIGSTNCGLGLQICTPNMELELGNNTAAFTNFLAS 779
            ..|.|....|..| ::...:.:||           .| .|..|..|::           |:|.::
Zfish   288 EIAACHSTHTSAAKTQSGQVYMWG-----------QC-RGQAIVLPHL-----------THFAST 329

  Fly   780 VYKSELILEPVDILALFSSKEQCDRGYYVQVHDVYPLAHSVLVLVDT--TTPLISSYEGDYPHL 841
                      .|:.|.|::.....|...::..|...:|.|:....|.  |:.|..|.:|.|.|:
Zfish   330 ----------DDVFACFATPSVMWRMLSMEHDDFLTVAQSLKKEFDNPETSDLEFSIDGKYIHV 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855
		S_TKc	105..354	CDD:214567
		ATS1	445..747	CDD:227511	79/291 (27%)
rcbtb1	NP_956285.1	RCC1	40..90	CDD:278826	10/50 (20%)
		RCC1_2	77..106	CDD:290274	10/28 (36%)
		RCC1	93..143	CDD:278826	16/49 (33%)
		RCC1	146..196	CDD:278826	16/50 (32%)
		RCC1	199..248	CDD:278826	13/48 (27%)
		RCC1	251..299	CDD:278826	14/47 (30%)
		BTB	360..464	CDD:279045	7/24 (29%)
		BTB	371..467	CDD:197585	5/13 (38%)
		SPOP_C_like	467..525	CDD:269810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010