DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and Nek5

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_006509217.1	Gene:	Nek5 / 330721	MGIID:	2142824	Length:	661	Species:	Mus musculus

Alignment Length:	330	Identity:	117/330 - (35%)
Similarity:	194/330 - (58%)	Gaps:	17/330 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 NYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVSYL 168
            |:..::::|:|:||...|.:.||:....|.|:|:|::    .::.:.|||.:.:::.|||||::.
Mouse     3 NFHLIKIIGEGTFGKVYLAKDKSESSHCVIKEISLTK----EKEASKNEVILLARMEHPNIVTFF 63

  Fly   169 GSFIKDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDLKT 233
            .||.::..|.|.|||.|||.|.|.| :||..:.|.|..|:..|.|||..:.::|...|||||:|:
Mouse    64 SSFQENGRLFIVMEYCDGGDLMQRI-QRQRGVMFSEDQILCWFVQISLGLKHIHDRKILHRDIKS 127

  Fly   234 ANVFLNRRGIV-KIGDFGISKIMNTKIH-AQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGE 296
            .|:||::.|:| |:||||.::.:|..:. |||..|||||.|||:|:.:.|:||:|||:|||:|.|
Mouse   128 QNIFLSKNGMVAKLGDFGTARTLNDSMELAQTCAGTPYYLSPEICQNRPYNNKTDIWSLGCVLYE 192

  Fly   297 MCCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVL--VYWIP 359
            :|.||..|.::|...||.||..|...|:...::..|:||:..|.:|....||:.:.:|  .:...
Mouse   193 LCTLKHPFESNNFHHLVLKICQGRVAPISPHFSRDLQSLIPQLFRVSPQDRPSVTSLLKRPFLET 257

  Fly   360 LIFRSL------GKNKGYSYEDDVG-GPGSDQLTAPVPAAAYSNVSMELELPTAQTETKQLMIAD 417
            ||.|||      .:.:.:::.:::. ||.:....:|. :|||.....|.:....:.|.:..:...
Mouse   258 LIARSLYPEVCSRRIQSHAHMENMAIGPTACWRVSPW-SAAYLQRKFEAQQYKLKVERQLGLRPS 321

  Fly   418 TAAPH 422
            :..||
Mouse   322 SVEPH 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	102/258 (40%)
		S_TKc	105..354	CDD:214567	100/250 (40%)
		ATS1	445..747	CDD:227511
Nek5	XP_006509217.1	STKc_Nek5	3..255	CDD:173765	102/256 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R445
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850