DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment niki and HERC2

DIOPT Version :9

Sequence 1:NP_651293.1 Gene:niki / 42959 FlyBaseID:FBgn0045980 Length:841 Species:Drosophila melanogaster
Sequence 2:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster


Alignment Length:892 Identity:184/892 - (20%)
Similarity:297/892 - (33%) Gaps:283/892 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 STCTRVLPTVFTITDGTTGAAS-------TSLAEAMSS----SKAQMPNRQESLLQLSVPRETGV 95
            ||...:..|:.::..||...|:       |.|.:..:|    .|...|..|||    |.|....|
  Fly  3610 STSQTIADTLISLGAGTPAVAAMLLETCITELEDLCTSRHCLGKLPKPVMQES----SHPYVDNV 3670

  Fly    96 GVAGPELANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPP-------GRDLAMNEV 153
            .|.|       .||:.|      |.:.|.:.|      .|.:..:.:.|       ||.|||...
  Fly  3671 NVTG-------VVRIPG------AEMLRLEFD------SQCSTEKRNDPLVIMDGTGRVLAMRSG 3716

  Fly   154 DVFSKLHHPNIVSYLG-----SFIKDNTL----------------LIEMEYADGGTLAQ------ 191
            ..|:  |....:..||     .|..|:::                .:....:|...|:|      
  Fly  3717 REFA--HWAPEIRVLGDELRWKFSSDSSVNGWGWRFWVHAIMPAATLGESGSDRAVLSQPSMALV 3779

  Fly   192 ------IIAERQGKLHFPERYIIAVFEQISS--------AINYMHSENILHRDLKTANVFLNRRG 242
                  .:|.||..:.......:|...|:.:        ::..:|:..:|.:..:..        
  Fly  3780 MSLLDSRLAPRQPSVLLRLASALAACSQLGALTTAQRIWSLRKLHAVLLLEQAPRPQ-------- 3836

  Fly   243 IVKIGDFGISKIMNTKIHAQTVLGTPYYFSPEMCEGKEYDN----------KSDIW----ALGCI 293
                 |..:|.::...|             ||:....||:.          .||.:    ||.|.
  Fly  3837 -----DPSLSTLLQPLI-------------PELLRQYEYEEPQVRGGIHLMHSDYFKTLAALACD 3883

  Fly   294 LGEMCCLKKTFAASNLSELVTKIMAGNYTPVPSG----------YTSGLRSLMSNLLQVEAPR-- 346
            :.....|..|.::|:.|.....|.:       :|          |...:|...|.:.:.|.||  
  Fly  3884 MQLDAALPATSSSSSSSAAPGAISS-------TGDVHKWAWFKRYCIAVRVAQSLIRRTELPRAF 3941

  Fly   347 ----RPTASEVLVYWIPLIFRSLGKNKGYSYEDDVGGPGSDQL--TAPVPAAAYSNVS----MEL 401
                |...:|:|    |....:...|.|..      .||:..|  |..:.::..||||    :..
  Fly  3942 CLEVRKKFAEML----PSSSSNSNANPGCQ------SPGASMLNSTTSLSSSTVSNVSPPPGITG 3996

  Fly   402 ELPTAQTETKQLMIADT---------AAPHEI-----LEKR-----------SVLY--------- 432
            |.|.......||....|         .|||:.     |.:|           |.:|         
  Fly  3997 EQPDLHCHAHQLESTSTLLHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGWGHNHRGQ 4061

  Fly   433 -------QLKAFGTCFSMA---PIQLPPKAVIVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLT 487
                   ::|....|.:::   |:||         |..:.....|..||..:|.|.|:.|:||:.
  Fly  4062 LGGLEGSRIKTPTPCEALSLLRPVQL---------AGGEQSLFAVTPDGKLFATGYGSGGRLGVG 4117

  Fly   488 ALEAWKHYPSRMESVRNYHV--VSACAGDGFTILVTQAGSLLSCGSNAHLALGQDEQRNYHSPKL 550
            ..::|. .|:.:.|:::..|  |:..:|....:.:|..|.:.:.|......||...:.:|..|||
  Fly  4118 GSDSWA-IPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKL 4181

  Fly   551 IARLADVRVEQVAAGLQHVLALSREGAVYVWGTSTCGALGLGNYQQQQ----------------- 598
            :..|..:.|..:|.|..|..|::..|.|..||....|.||.|:.:.|.                 
  Fly  4182 VEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIA 4246

  Fly   599 ------------------------------------KFPQKILLSHVKTKPSKIYCGPDTSAVLF 627
                                                |.|.|| .|.......|:.||...|..|.
  Fly  4247 CGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKI-ESLAGLGVVKVECGSQFSVALT 4310

  Fly   628 ANGELHVCGSNDYNKLG------FQRSAKITAFKKVQLPHKVTQACFSSTHSVFLVEGGYVYTMG 686
            .:|.::..|..|:::||      .:|..|:.|.:    ..|:......|.|.|...:.|.|||.|
  Fly  4311 KSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQ----GKKIISIATGSLHCVACSDSGEVYTWG 4371

  Fly   687 RNAEGQRGIRHCNSVDHPTLVDSVKSRYIVKANCSDQCTIVASEDNI 733
            .|.|||.|.....::..|.||.:::.::|||..|....|:..|...:
  Fly  4372 DNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQL 4418

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nikiNP_651293.1 STKc_Nek 104..359 CDD:270855 56/332 (17%)
S_TKc 105..354 CDD:214567 55/326 (17%)
ATS1 445..747 CDD:227511 84/350 (24%)
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 6/29 (21%)
RCC1 4154..4203 CDD:278826 13/48 (27%)
RCC1 4206..4257 CDD:278826 9/50 (18%)
RCC1 4260..4309 CDD:278826 9/49 (18%)
RCC1 4312..4360 CDD:278826 11/51 (22%)
RCC1 4364..4413 CDD:278826 18/48 (38%)
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.920

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