DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and Nek11

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_008764752.1	Gene:	Nek11 / 315978	RGDID:	1308801	Length:	664	Species:	Rattus norvegicus

Alignment Length:	353	Identity:	120/353 - (33%)
Similarity:	181/353 - (51%)	Gaps:	34/353 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 TGVGVAGPEL--ANYEKVRVVGQGSFGIAILY--RRKSDGHQI-VFKQINLSELSPPGRDLAMNE 152
            |.:.|..|.:  ..|...:.:|.||||...|.  ::...|.:: |.|:|::.||:|.....|..|
  Rat    13 TAIPVYPPTVIARRYVLQQKLGSGSFGTVYLVSDKKAKHGEELKVLKEISVGELNPNESVQASME 77

  Fly   153 VDVFSKLHHPNIVSYLGSFIKDNTLLIEMEYADGGTLAQIIAE--RQGKLHFPERYIIAVFEQIS 215
            ..:.|.|:||.||.:..||::..|..|..||.:|..|...|.|  ..||: ||:..|:..|.|:.
  Rat    78 AQLLSTLNHPAIVRFHESFMEQGTFCIITEYCEGRDLDYKIQEYKEAGKI-FPDNQIVEWFIQLL 141

  Fly   216 SAINYMHSENILHRDLKTANVFLNRRGIVKIGDFGISK-IMNTKIHAQTVLGTPYYFSPEMCEGK 279
            ..::|||...|||||||:.|:|| :..:.||||||:|: :|.:...|.|:.|||||.|||..:.:
  Rat   142 LGVDYMHERRILHRDLKSKNIFL-KNNLPKIGDFGVSRLLMGSCELATTLTGTPYYMSPEALKHQ 205

  Fly   280 EYDNKSDIWALGCILGEMCCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEA 344
            ..|.|||||:|.|||.||||:...|:.||...:|..|:.||...:|..|...|..:||.:|....
  Rat   206 GCDAKSDIWSLACILYEMCCMDHAFSGSNFLSVVLNIVEGNTPSLPDRYPRELNIIMSRMLNKSP 270

  Fly   345 PRRPTASEVL--VYWIPLIFRSLGKNKGYSYEDDVGGPGSDQLTAPVPAAAYSNVSMELEL---- 403
            ..||:|:|:|  .|....:.:.:.|:...:.||       .:.:|....||::..:|:.|:
  Rat   271 SLRPSAAEILKAPYVEERLQQLMYKHPEATLED-------KRNSACQKEAAHAVNAMQREIYLQT 328

  Fly   404 -----------PTAQTETKQLMIADTAA 420
                       ||.:...::|..||..|
  Rat   329 LRALCVVQKITPTERVWPRKLQAADERA 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	103/262 (39%)
		S_TKc	105..354	CDD:214567	101/254 (40%)
		ATS1	445..747	CDD:227511
Nek11	XP_008764752.1	STKc_Nek11	26..285	CDD:270861	102/260 (39%)
Nek11	XP_008764752.1	S_TKc	27..285	CDD:214567	102/259 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820