DRSC/TRiP Functional Genomics Resources

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Protein Alignment niki and Herc1

DIOPT Version :9

Sequence 1:NP_651293.1 Gene:niki / 42959 FlyBaseID:FBgn0045980 Length:841 Species:Drosophila melanogaster
Sequence 2:XP_017451567.1 Gene:Herc1 / 315771 RGDID:1306366 Length:4876 Species:Rattus norvegicus


Alignment Length:262 Identity:78/262 - (29%)
Similarity:127/262 - (48%) Gaps:12/262 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly   460 SDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRMESVRNYHVVSACAGDGFTILVTQAG 524
            ||.|.:.:.|.|..::||:|.:|:||....:..:. |.::|:::...||....|...:.:||..|
  Rat  4105 SDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRR-PRQIEALQGEEVVQMSCGFKHSAVVTSDG 4168

  Fly   525 SLLSCGSNAHLALGQDEQRNYHSPKLIARLADVRVEQVAAGLQHVLALSREGA-VYVWGTSTCGA 588
            .|.:.|:..:..||.....|...|:.:..|...::.|||.||.|.||:|.:|: |:.:|....|.
  Rat  4169 KLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGK 4233

  Fly   589 LGLGNYQQQQKFPQKI-LLSHVKTKPSKIYCGPDTSAVLFANGELHVCGSNDYNKLGFQRSAKIT 652
            ||||| ...:..|||: :|..:..|  |:.||...|..|..:|.::..|.:  ..:|........
  Rat  4234 LGLGN-STAKSSPQKVDVLCGIGIK--KVACGTQFSVALTKDGHVYTFGQD--RLIGLPEGRARN 4293

  Fly   653 AFKKVQLP----HKVTQACFSSTHSVFLVEGGYVYTMGRNAEGQRGIRHCNSVDHPTLVDSVKSR 713
            ..:..|:|    ..:......:.|::.|...|.||..|.|:|||.|:.|.|.|..||||..::.:
  Rat  4294 HNRPQQIPVLAGVVIEDVAVGAEHTLALASTGDVYAWGSNSEGQLGLGHTNHVREPTLVTVLQGK 4358

  Fly   714 YI 715
            .|
  Rat  4359 NI 4360

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nikiNP_651293.1 STKc_Nek 104..359 CDD:270855
S_TKc 105..354 CDD:214567
ATS1 445..747 CDD:227511 78/262 (30%)
Herc1XP_017451567.1 RCC1 421..472 CDD:278826
RCC1 476..526 CDD:278826
RCC1 529..576 CDD:278826
RCC1 579..629 CDD:278826
RCC1 633..680 CDD:278826
RCC1_2 667..696 CDD:290274
RCC1 683..733 CDD:278826
SPRY_HERC1 2030..2187 CDD:293939
UBA_HERC1 2751..2794 CDD:270584
WD40 3409..3793 CDD:225201
WD40 3439..3790 CDD:295369
WD40 repeat 3447..3490 CDD:293791
WD40 repeat 3504..3539 CDD:293791
WD40 repeat 3544..3591 CDD:293791
WD40 repeat 3600..3638 CDD:293791
WD40 repeat 3644..3679 CDD:293791
WD40 repeat 3687..3718 CDD:293791
WD40 repeat 3765..3801 CDD:293791
RCC1 4060..4112 CDD:278826 3/6 (50%)
RCC1 4115..4164 CDD:278826 12/49 (24%)
RCC1 4167..4216 CDD:278826 15/48 (31%)
RCC1 4219..4269 CDD:278826 18/52 (35%)
RCC1 4272..4321 CDD:278826 6/50 (12%)
RCC1_2 4308..4337 CDD:290274 8/28 (29%)
RCC1 4325..4373 CDD:278826 17/36 (47%)
HECTc 4488..4856 CDD:238033
HECTc 4519..4852 CDD:214523
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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