DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and Hectd3

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_008762291.1	Gene:	Hectd3 / 313525	RGDID:	1309823	Length:	861	Species:	Rattus norvegicus

Alignment Length:	373	Identity:	71/373 - (19%)
Similarity:	120/373 - (32%)	Gaps:	131/373 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 PVPS-GYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIPLIFRSLGKNKGYSYEDDVGGPGSDQLT 386
            |.|: .||..::    .||.|.........|.|:::   ::..|||      ||:..| ...|..
  Rat   194 PQPAEAYTEAVQ----RLLYVPPTWTYECDEDLIHF---LYDHLGK------EDENLG-SVKQYV 244

  Fly   387 APVPAAAY-----------SNVSMELELPTAQ------------TETKQLMIADTAAPHEILEKR 428
            ..:..::|           ||.....|...:|            |..|:|::.........:.||
  Rat   245 ESIDVSSYTEEFNVSCLTDSNADTYWESDGSQCQHWVRLTMKKGTIVKKLLLTVDTTDDNFMPKR 309

  Fly   429 SVLY-----QLKAFGTCFSMAPIQLPPKAVIVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTA 488
            .|:|     .||      .::.:.: .:.:|.||.:.:...|
  Rat   310 VVVYGGEGDNLK------KLSDVNI-DETLIGDVCVLEDMTV----------------------- 344

  Fly   489 LEAWKHYPSRMESVRNYHVVSACAGDGFTI----LVTQAGSLLSCGSNAHL-----------ALG 538
                 |.|     |....:|. |..||..:    :..::......|.||.|           ..|
  Rat   345 -----HLP-----VIEIRIVE-CRDDGIDVRLRGVKIKSSRQRELGLNADLFQPASLVRYPRLEG 398

  Fly   539 QDEQRNYHSPKLIARLADVRVEQVAAGLQHVLALSREGAVYVWGTSTCGALGLGNYQQQQKFPQK 603
            .|.:..|....|:.|...: ::.|   |.|:        |..|..:      ||.:.:.::..|.
  Rat   399 TDPEVLYRRAVLLQRFIKI-LDSV---LHHL--------VPAWDHT------LGTFSEIKQVKQF 445

  Fly   604 ILLSHVKTKPSKI-YCGPDTSAV-------LFANGEL----HVCGSND 639
            :|||  :.:||.: .|..|:.:.       |:.|..|    ..|.|.|
  Rat   446 LLLS--RQRPSLVTQCLRDSESSKPSFMPRLYINRRLAMEHRACPSRD 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	9/36 (25%)
		S_TKc	105..354	CDD:214567	8/31 (26%)
		ATS1	445..747	CDD:227511	41/222 (18%)
Hectd3	XP_008762291.1	APC10-HECTD3	238..371	CDD:176487	27/174 (16%)
Hectd3	XP_008762291.1	HECT	579..845	CDD:395507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010