DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment niki and Herc2

DIOPT Version :9

Sequence 1:NP_651293.1 Gene:niki / 42959 FlyBaseID:FBgn0045980 Length:841 Species:Drosophila melanogaster
Sequence 2:XP_006229362.1 Gene:Herc2 / 308669 RGDID:1307989 Length:4836 Species:Rattus norvegicus


Alignment Length:965 Identity:204/965 - (21%)
Similarity:322/965 - (33%) Gaps:311/965 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 AKASSLPIFNGRITDATTLTTSSLQLPLGQNT-QRKQ---STCTRVLPTVFT------------- 53
            |.||.:......:....::..:.|:..|..|. |.|:   |:...|.|:..|             
  Rat  3436 APASDVSAMASPMNVEESMLAADLEDRLSPNLWQEKREIVSSEDAVTPSAVTPSAPSASSRPFIP 3500

  Fly    54 ITDGTTGAASTSLAEAMSSSKAQMPNRQES-------------------------LLQLSV---- 89
            :|| ..||||. :||.|:.:|..:.::.::                         ||:|||    
  Rat  3501 VTD-DPGAASI-IAETMTKTKEDVESQNKTSGPEPQSLDEFTSLLIPDDTRVVVDLLKLSVCSRA 3563

  Fly    90 ---PRE------TGVGVAGPELAN---------YEKVRVVGQ----------------------- 113
               .||      :|:|:|.|::|:         .|.|....|                       
  Rat  3564 GDRGREVLSAVLSGMGIAYPQVADMLLELCVTELEDVATDSQSGRLSSQPVVVESSHPYTDDTST 3628

  Fly   114 -------GSFGIAILYRRKSDGHQ-----IVFKQIN--------------LSELSPPGRDL---- 148
                   |:.|:.:.:.|:....:     .|...:|              .|||..||.:|    
  Rat  3629 SGTVKIPGAEGLRVEFDRQCSTERRHDPLTVMDGVNRIVSVRSGREWSDWSSELRIPGDELKWKF 3693

  Fly   149 --------------------AMNEVDVFSK---LHHP--NIVSYLGSF---IKDNTLLIEMEYAD 185
                                |....|:.|.   |..|  ::|:.|..|   :..|..::....|.
  Rat  3694 ISDGSVNGWGWRFTVYPIMPAAGPKDLLSDRCVLSCPSMDLVTCLLDFRLNLTSNRSIVPRLAAS 3758

  Fly   186 GGTLAQIIA----ERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIVKI 246
            ....||:.|    .|...|....|.:...|.| |..||.:..||               .|..:.
  Rat  3759 LAACAQLSALAASHRMWALQRLRRLLTTEFGQ-SININRLLGEN---------------DGETRA 3807

  Fly   247 GDFGISKIMNTKIHAQTVLGTP-------YYFSPEMCEGKEYDNK---SDIWALGCILGEM---- 297
            ..|..|.:      |..|.|.|       .|..|.:..||:..:.   ..:.||.|.| |:    
  Rat  3808 LSFTGSAL------AALVKGLPEALQRQFEYEDPIVRGGKQLLHSPFFKVLVALACDL-ELDTLP 3865

  Fly   298 CC--------LKKTFAASNLSELVTKIMAGNYTPVPSGY----TSGLRSLMSN------LLQVEA 344
            ||        .::...||.::..:.|     .||:|..:    ...:|.||::      |.:..:
  Rat  3866 CCAETHKWAWFRRYCMASRVAVALDK-----RTPLPRLFLDEVAKKIRELMADSESMDVLHESHS 3925

  Fly   345 PRRPTASEVLVYWIPLIFRSLGKNK------------------GYSYEDDVGGPGSDQLTAPVPA 391
            ..:....|.||.|:         |:                  |:::...:||....::..|.|.
  Rat  3926 IFKREQDEQLVQWM---------NRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPC 3981

  Fly   392 AAYSNVSMELELPTAQTETKQLMIADTAAPHEILEKRSVLYQLKAFGTCFSMA------------ 444
            .|.:                      |..|.:::.....|:.:.|.|..::..            
  Rat  3982 EALA----------------------TLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGT 4024

  Fly   445 -PIQLP------PKAVIVDVAMSD--SHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKH------ 494
             .:..|      ....|..||::.  .|.:.::.:|..|:|||...|:||        |      
  Rat  4025 ESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLG--------HGNRSPC 4081

  Fly   495 -YPSRMESVRNYHVVSACAGDGFTILVTQAGSLLSCGSNAHLALGQDEQRNYHSPKLIARLADVR 558
             .|..:||:|...||...||...:..||.||.|.:.|...:..||..:..:...|||:..|...|
  Rat  4082 DRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHR 4146

  Fly   559 VEQVAAGL--QHVLALSREGAVYVWGTSTCGALGLGNYQQQQKFPQKILLSHVKTKPSKIYCGPD 621
            |..:|.|.  ...|.|:.:..|:.||....|.||.|. ....|.|.|| .|.......|:.||..
  Rat  4147 VIDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGG-SDGCKVPMKI-DSLTGLGVVKVECGSQ 4209

  Fly   622 TSAVLFANGELHVCGSNDYNKLGFQRSAKITAFKKVQ--LPHKVTQACFSSTHSVFLVEGGYVYT 684
            .|..|..:|.::..|..||::||......:...::||  ...||......|.|.|...|.|.|||
  Rat  4210 FSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYT 4274

  Fly   685 MGRNAEGQRGIRHCNSVDHPTLVDSVKSRYIVKANCSDQCTIVASEDNIITVWGT 739
            .|.|.|||.|....|::..|.||.:::.:.:.:..|....|:         .|.|
  Rat  4275 WGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTL---------AWST 4320

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nikiNP_651293.1 STKc_Nek 104..359 CDD:270855 69/380 (18%)
S_TKc 105..354 CDD:214567 66/365 (18%)
ATS1 445..747 CDD:227511 89/314 (28%)
Herc2XP_006229362.1 ATS1 <494..787 CDD:227511
Cyt-b5 1212..1283 CDD:395121
MIB_HERC2 1871..1931 CDD:399589
UBA_HERC2 2461..2508 CDD:270585
Cul7 2555..2632 CDD:402903
SH3_15 2640..2697 CDD:408152
ZZ_HERC2 2707..2751 CDD:239084
APC10-HERC2 2766..2911 CDD:176485
ATS1 2957..3323 CDD:227511
ATS1 4025..4330 CDD:227511 89/315 (28%)
HECTc 4423..4794 CDD:238033
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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