DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment niki and Nek9

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_001100217.2	Gene:	Nek9 / 299204	RGDID:	1307187	Length:	976	Species:	Rattus norvegicus

Alignment Length:	719	Identity:	222/719 - (30%)
Similarity:	349/719 - (48%)	Gaps:	119/719 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 GVAGPELANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLH 160
            |.|..|..:|..:||:|:|:||.|.||||..|...:|:|:::|:.||...|..|:||:.:.:.|.
  Rat    42 GAAEQEELHYIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQ 106

  Fly   161 HPNIVSYLGSFIKDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSEN 225
            |.||::|...|:.:.|||||:||.:||.|...|..::.|| |.|..::....||.||::.:|...
  Rat   107 HDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKL-FEEEMVVWYLFQIVSAVSCIHKAG 170

  Fly   226 ILHRDLKTANVFLNRRGIVKIGDFGISKIMNTKIH-AQTVLGTPYYFSPEMCEGKEYDNKSDIWA 289
            |||||:||.|:||.:..::|:||:|::|.:|::.. |:|::|||||.|||:|:|.:|:.||||||
  Rat   171 ILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWA 235

  Fly   290 LGCILGEMCCLKKTFAASNLSELVTKIMAG-NYTPVPSG-YTSGLRSLMSNLLQVEAPRRPTASE 352
            :||::.|:..||:||.|:|...|..||:.| ....|.|. |:.||..|:...|..:..|||||..
  Rat   236 VGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLGLIQLVHACLDQDPERRPTADA 300

  Fly   353 VLVYWIPLIFRSLGKNKGYSYEDDVGGPGSDQLTAPVPAAAYSNVSMELELPTAQTETKQLMIAD 417
            :|.  :||:     :.:....|:.|     ..|.||......|.|
  Rat   301 LLD--LPLL-----RKRRREMEEKV-----TLLNAPTKRPRSSTV-------------------- 333

  Fly   418 TAAPHEILEKRSVLYQLKAFGTCFSMAPIQLPPKAVIV-------DVAMSDSHFVVVNEDGSAYA 475
            |.||..::..|:....:...|.       ..|.|..::       .|...::||.||..:...|.
  Rat   334 TEAPIAVVTSRTSEVYVWGGGK-------STPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYT 391

  Fly   476 W-----GEGTHGQLGLTALEAWKHYPSRMESVRNYHVVSACAGDGFTILVTQAGSLLSCGSNAHL 535
            |     |...|||||.....:::. |..:|.::...:.....||.||:.||..|.|.:.||:.:.
  Rat   392 WVNMQGGTKLHGQLGHGDKASYRQ-PKHVEKLQGKAIHQVSCGDDFTVCVTDEGQLYAFGSDYYG 455

  Fly   536 ALGQDE----------QRNY--HSPKLIARLADVRVEQVAAGLQHVLALSREGAVYVWGTSTCGA 588
            .:|.|:          |.|:  .:|          ||||:.|..||:.|:|...||.||....|.
  Rat   456 CMGVDKVSGPEVLEPMQLNFFLSNP----------VEQVSCGDNHVVVLTRNKEVYSWGCGEYGR 510

  Fly   589 LGLGNYQ-----QQQKFPQKILLSHVKTKPSKIYCGPDTSAVLFANGELHVCGSNDYNKLGFQR- 647
            |||.:.:     |:...|:.:::..|:       ||.|.:.:|..:|::..||.|::||||..:
  Rat   511 LGLDSEEDYYTPQRVDVPKALIIVAVQ-------CGCDGTFLLTQSGKVLACGLNEFNKLGLNQC 568

  Fly   648 ---------------SAKITAFKKVQLPHKVTQACFSSTHSVFLVEGGYVYTMGRNAEGQRGIRH 697
                           :...|..|::.. :|:.......||:..:.|.|.:.|.|.|..||.|:.:
  Rat   569 MSGIINHEAYHEVPYTTSFTLAKQLSF-YKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGN 632

  Fly   698 ------CNSVDHPTLVDSVKSRYIVKANCSDQCTIVASEDNIITVWGT-RNGLPGIGSTNCGLGL 755
                  .|.:..|     :..:.:::.:|.|:.||.|::||.|..||. .||...:..|....|.
  Rat   633 YKKRLGINLLGGP-----LGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAMTPTERPHGS 692

  Fly   756 QICT 759
            .|||
  Rat   693 DICT 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	109/257 (42%)
		S_TKc	105..354	CDD:214567	108/251 (43%)
		ATS1	445..747	CDD:227511	91/353 (26%)
Nek9	NP_001100217.2	STKc_Nek9	50..297	CDD:270860	105/247 (43%)
Nek9	NP_001100217.2	ATS1	344..687	CDD:227511	93/373 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337273
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48158
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45175
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860