DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment niki and Rcc2

DIOPT Version :9

Sequence 1:NP_651293.1 Gene:niki / 42959 FlyBaseID:FBgn0045980 Length:841 Species:Drosophila melanogaster
Sequence 2:XP_038967259.1 Gene:Rcc2 / 298594 RGDID:1309986 Length:520 Species:Rattus norvegicus


Alignment Length:528 Identity:127/528 - (24%)
Similarity:188/528 - (35%) Gaps:146/528 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   370 GYSYEDD----VGGPGSDQLTAPVPAAAYSNVSMELELPTAQTETKQLMIADTAAPHEILEKRSV 430
            |.|.::|    .|.||..:.||. ||.| ...|....:.|....||:.:         .||....
  Rat    47 GSSGDEDGPELDGAPGGGKRTAR-PATA-GKASGAAAIITEPEHTKERV---------KLEGSKC 100

  Fly   431 LYQLKAFG-TCFSMAPIQLPPKAVIVDVAMSDSHFVVVNEDGSAY------AWGEGTHGQLGLTA 488
            ..||..|| |.:.:...:..||                  ..:||      .||...:|.|    
  Rat   101 KGQLLIFGATNWDLIGRKEVPK------------------QQAAYRNLGQNLWGPHRYGCL---- 143

  Fly   489 LEAWKHYPSRMESVRNYHVVS-ACAGDGFTILVTQAGSLLSCGSNAHLALGQDEQRNYHSPKLIA 552
                       ..||...||| :||  ..::|:|..|.|.|.|.|....||..:.:...:|:||.
  Rat   144 -----------SGVRVRTVVSGSCA--AHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIE 195

  Fly   553 RLADVRVEQVAAGLQHVLALSREGAVYVWGTSTCGALGLGNYQQQQKFPQKILLSHVKTKP-SKI 616
            .|:...:...|.|..|.|||:..|:|:.:|.:..|.|||||.......|.:|:.:   .:| :|:
  Rat   196 ALSHEAIVLAACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN---GQPITKM 257

  Fly   617 YCGPDTSAVLFANGELHVCGSNDYNKLGFQRSAKITA-------------------FKKVQ---- 658
            .||.:.|.::...|.|:..|..:|.:||.....|..|                   .:|.:    
  Rat   258 ACGAEFSMLMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQI 322

  Fly   659 --LPHKVTQ--ACFSSTHSVFLVEGGYVYTMGRNAEGQRGIRHCNSVDH--PTLVD--SVKSRYI 715
              :|:.|.:  || .:.|::.|.....|::.|....|:.|  |....|.  |.||.  ....|..
  Rat   323 LPVPNVVVRDVAC-GANHTLVLDSQKRVFSWGFGGYGRLG--HAEQKDEMVPRLVKLFDFPGRGA 384

  Fly   716 VKANCSDQCTIVASEDNIITVWGTRN-------------GLPG--IGSTNCGLGLQIC------- 758
            .:......|:...||...:..||..|             .|.|  |.|..||....|.       
  Rat   385 TQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI 449

  Fly   759 ----TPNM-ELELGNNTAAFTNFLASVYKSELILEPVDIL-ALFSSKEQCDRGYYVQVHDVYPLA 817
                :|.. ||..|::..          ||....:.|..| .:||  ||...||          :
  Rat   450 SWGPSPTFGELGYGDHKP----------KSSTAAQEVKTLDGIFS--EQVAMGY----------S 492

  Fly   818 HSVLVLVD 825
            ||:::..|
  Rat   493 HSLVIARD 500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nikiNP_651293.1 STKc_Nek 104..359 CDD:270855
S_TKc 105..354 CDD:214567
ATS1 445..747 CDD:227511 83/355 (23%)
Rcc2XP_038967259.1 ATS1 129..479 CDD:227511 91/382 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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