Protein Alignment niki and Nek8

DIOPT Version :10

• Sequence 1: NP_651293.1
• Gene: niki / 42959
• FlyBaseID: FBgn0045980
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: NP_001099274.1
• Gene: Nek8 / 287473
• RGDID: 1306897
• Length: 698
• Species: Rattus norvegicus
• Alignment Length: 700
• Identity: 230/700 - (32%)
• Similarity: 336/700 - (48%)
• Gaps: 119/700 - (17%)

  Fly   102 LANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVS 166
            :..||::||||:|:|||..|..||:|...::.|||.:.:::...|..|.||..|...|:|||::.
  Rat     1 MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIE 65

  Fly   167 YLGSFIKDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDL 231
            |..:|::|..|:|.||||.|||||:.|.:|...| ..|..|:..|.||..|::::|:..||||||
  Rat    66 YYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSL-LEEETILHFFVQILLALHHVHTHLILHRDL 129

  Fly   232 KTANVFLNR-RGIVKIGDFGISKIMNTKIHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILG 295
            ||.|:.|:: |.:|||||||||||:::|..|.||:|||.|.|||:||||.|:.|||||||||:|.
  Rat   130 KTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLY 194

  Fly   296 EMCCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIPL 360
            |:..||:.|.|:||..||.|||:|.:.|:...|:..||.|:.:||.:|..:||..|.::..  ||
  Rat   195 ELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQ--PL 257

  Fly   361 IFRSLGKNKGYSYEDDVG-----------------GPGSDQLTA-----------------PVP- 390
            ..|:|     .:...|||                 .|||....|                 |.|
  Rat   258 CIRAL-----LNIHTDVGSVRMRRAEKCLTPGTPMAPGSTGSRATSARCRGVPRGPVRPAIPPPL 317

  Fly   391 AAAYS---NVSMELELPTAQTETKQLMIADTAAPHEILEKRSVLYQLKAFGT---CFSMAPIQLP 449
            ::.|:   .:|:.|.||...||..|:....|.........|.:|::....||   ......::||
  Rat   318 SSVYAWGGGLSIPLRLPMPNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGTGGGTLLPGAVELP 382

  Fly   450 -PKAVIVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRMESVRNYHVVSACAG 513
             |:.|        |.|:               .||.|:|.    ||.              || |
  Rat   383 QPQFV--------SRFL---------------EGQSGVTI----KHV--------------AC-G 405

  Fly   514 DGFTILVTQAGSLLSCGSNAHLALGQDEQRNYHSPKLIARLADVRVEQVAAGLQHVLALSREGAV 578
            |.||..:|..|.:::.||.::..||.....:...|.::..|....:.|||.|..||||||.:|.:
  Rat   406 DLFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSADGEL 470

  Fly   579 YVWGTSTCGALGLGNYQQQQKFPQKILLSHVKTKPSKIYCGPDTSAVLFANGELHVCGSNDYNKL 643
            :.||....|.||||. ::....||::.:...: :..::.||.|.|.:|.:.|.:..||||.:|||
  Rat   471 FAWGRGDGGRLGLGT-RESHNCPQQVPMVPGQ-EAQRVVCGIDCSMILTSPGRVLACGSNRFNKL 533

  Fly   644 GFQRSAKITAFKKVQLPHKVTQACFSST--------------------HSVFLVEGGYVYTMGRN 688
            |..    ..:.::..:||:..:...|.|                    ||..:...|..||.|.|
  Rat   534 GLD----CLSLEEEPVPHQQVEEALSFTPLGSAPLDRETLLCVDLGTAHSAAVTASGACYTFGSN 594

  Fly   689 AEGQRGIRHCNSVDHPTLVDSVKSRYIVKANCSDQCTIVASEDNIITVWG 738
            ..||.|.........|..|..::...:|...|.|..|:....:..:..||
  Rat   595 QHGQLGTSSRRVSRAPCRVQGLEGIKMVMVACGDAFTVAIGAEGEVYSWG 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	122/255 (48%)
		ATS1	433..749	CDD:444065	83/329 (25%)
Nek8	NP_001099274.1	STKc_Nek8	3..258	CDD:270859	123/257 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..307		4/25 (16%)
		ATS1	401..>690	CDD:444065	70/264 (27%)
		RCC1 1	415..466		16/50 (32%)
		RCC1 2	467..518		15/52 (29%)
		RCC1 3	520..571		13/54 (24%)
		RCC1 4	585..636		14/50 (28%)
		RCC1 5	638..689		1/6 (17%)