DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and NEK8

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_835464.1	Gene:	NEK8 / 284086	HGNCID:	13387	Length:	692	Species:	Homo sapiens

Alignment Length:	694	Identity:	224/694 - (32%)
Similarity:	329/694 - (47%)	Gaps:	113/694 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 LANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVS 166
            :..||::||||:|:|||..|..||:|...::.|||.:.:::...|..|.||..|...|:|||::.
Human     1 MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIE 65

  Fly   167 YLGSFIKDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDL 231
            |..:|::|..|:|.||||.|||||:.|.:|...| ..|..|:..|.||..|::::|:..||||||
Human    66 YYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSL-LEEETILHFFVQILLALHHVHTHLILHRDL 129

  Fly   232 KTANVFLNR-RGIVKIGDFGISKIMNTKIHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILG 295
            ||.|:.|:: |.:|||||||||||:::|..|.||:|||.|.|||:||||.|:.|||||||||:|.
Human   130 KTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLY 194

  Fly   296 EMCCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIPL 360
            |:..||:.|.|:||..||.|||:|.:.|:...|:..||.|:.:||.:|..:||..|.::..  ||
Human   195 ELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQ--PL 257

  Fly   361 IFRSLGKNKGYSYEDDVG------------------------------GPGSDQLTAPVPAAAYS 395
            ..|:|     .:...|||                              ||....:..|: ::.|:
Human   258 CIRAL-----LNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPRGPVRPAIPPPL-SSVYA 316

  Fly   396 ---NVSMELELPTAQTETKQLMIADTAAPHEILEKRSVLYQ---LKAFGTCFSMAPIQLPPKAVI 454
               .:...|.||...||..|:....|.........|.:|::   |.|.|.......::.|....|
Human   317 WGGGLGTPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQFI 381

  Fly   455 VDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRMESVRNYHVVSACAGDGFTIL 519
                   |.|:               .||.|:|.    ||.              || ||.||..
Human   382 -------SRFL---------------EGQSGVTI----KHV--------------AC-GDFFTAC 405

  Fly   520 VTQAGSLLSCGSNAHLALGQDEQRNYHSPKLIARLADVRVEQVAAGLQHVLALSREGAVYVWGTS 584
            :|..|.:::.||.::..||.....:...|.::..|....:.|||.|..||||||.|..::.||..
Human   406 LTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRG 470

  Fly   585 TCGALGLGNYQQQQKFPQKILLSHVKTKPSKIYCGPDTSAVLFANGELHVCGSNDYNKLGFQRSA 649
            ..|.||||. ::....||::.:...: :..::.||.|:|.:|...|:...||||.:||||...
Human   471 DSGRLGLGT-RESHSCPQQVPMPPGQ-EAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDH-- 531

  Fly   650 KITAFKKVQLPHKVTQACFSST--------------------HSVFLVEGGYVYTMGRNAEGQRG 694
              .:..:..:||:..:...|.|                    ||..:...|..||.|.|..||.|
Human   532 --LSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLG 594

  Fly   695 IRHCNSVDHPTLVDSVKSRYIVKANCSDQCTIVASEDNIITVWG 738
            .........|..|..::...:....|.|..|:....::.:..||
Human   595 TNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWG 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	122/255 (48%)
		S_TKc	105..354	CDD:214567	122/249 (49%)
		ATS1	445..747	CDD:227511	79/314 (25%)
NEK8	NP_835464.1	STKc_Nek8	3..258	CDD:270859	123/257 (48%)
		RCC1	276..657	CDD:332518	95/411 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..301		0/23 (0%)
		RCC1 1	312..350		8/37 (22%)
		RCC1 2	410..461		17/50 (34%)
		RCC1 3	462..513		14/52 (27%)
		RCC1 4	580..631		13/50 (26%)
		RCC1 5	632..684		2/7 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	243	1.000	Domainoid score	I2221
eggNOG	1	0.900	-	-		E1_KOG0589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H84442
Inparanoid	1	1.050	331	1.000	Inparanoid score	I2441
Isobase	1	0.950	-	0	Normalized mean entropy	S2769
OMA	1	1.010	-	-		QHG48158
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	1	1.000	-	-		otm41040
orthoMCL	1	0.900	-	-		OOG6_106447
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R445
SonicParanoid	1	1.000	-	-		X891
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.760