Protein Alignment niki and NEK8

DIOPT Version :10

• Sequence 1: NP_651293.1
• Gene: niki / 42959
• FlyBaseID: FBgn0045980
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: NP_835464.1
• Gene: NEK8 / 284086
• HGNCID: 13387
• Length: 692
• Species: Homo sapiens
• Alignment Length: 694
• Identity: 224/694 - (32%)
• Similarity: 329/694 - (47%)
• Gaps: 113/694 - (16%)

  Fly   102 LANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVS 166
            :..||::||||:|:|||..|..||:|...::.|||.:.:::...|..|.||..|...|:|||::.
Human     1 MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIE 65

  Fly   167 YLGSFIKDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDL 231
            |..:|::|..|:|.||||.|||||:.|.:|...| ..|..|:..|.||..|::::|:..||||||
Human    66 YYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSL-LEEETILHFFVQILLALHHVHTHLILHRDL 129

  Fly   232 KTANVFLNR-RGIVKIGDFGISKIMNTKIHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILG 295
            ||.|:.|:: |.:|||||||||||:::|..|.||:|||.|.|||:||||.|:.|||||||||:|.
Human   130 KTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLY 194

  Fly   296 EMCCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIPL 360
            |:..||:.|.|:||..||.|||:|.:.|:...|:..||.|:.:||.:|..:||..|.::..  ||
Human   195 ELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQ--PL 257

  Fly   361 IFRSLGKNKGYSYEDDVG------------------------------GPGSDQLTAPVPAAAYS 395
            ..|:|     .:...|||                              ||....:..|: ::.|:
Human   258 CIRAL-----LNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPRGPVRPAIPPPL-SSVYA 316

  Fly   396 ---NVSMELELPTAQTETKQLMIADTAAPHEILEKRSVLYQ---LKAFGTCFSMAPIQLPPKAVI 454
               .:...|.||...||..|:....|.........|.:|::   |.|.|.......::.|....|
Human   317 WGGGLGTPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQFI 381

  Fly   455 VDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRMESVRNYHVVSACAGDGFTIL 519
                   |.|:               .||.|:|.    ||.              || ||.||..
Human   382 -------SRFL---------------EGQSGVTI----KHV--------------AC-GDFFTAC 405

  Fly   520 VTQAGSLLSCGSNAHLALGQDEQRNYHSPKLIARLADVRVEQVAAGLQHVLALSREGAVYVWGTS 584
            :|..|.:::.||.::..||.....:...|.::..|....:.|||.|..||||||.|..::.||..
Human   406 LTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRG 470

  Fly   585 TCGALGLGNYQQQQKFPQKILLSHVKTKPSKIYCGPDTSAVLFANGELHVCGSNDYNKLGFQRSA 649
            ..|.||||. ::....||::.:...: :..::.||.|:|.:|...|:...||||.:||||...
Human   471 DSGRLGLGT-RESHSCPQQVPMPPGQ-EAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDH-- 531

  Fly   650 KITAFKKVQLPHKVTQACFSST--------------------HSVFLVEGGYVYTMGRNAEGQRG 694
              .:..:..:||:..:...|.|                    ||..:...|..||.|.|..||.|
Human   532 --LSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLG 594

  Fly   695 IRHCNSVDHPTLVDSVKSRYIVKANCSDQCTIVASEDNIITVWG 738
            .........|..|..::...:....|.|..|:....::.:..||
Human   595 TNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWG 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	122/255 (48%)
		ATS1	433..749	CDD:444065	82/329 (25%)
NEK8	NP_835464.1	STKc_Nek8	3..258	CDD:270859	123/257 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	277..301		0/23 (0%)
		RCC1 1	312..350		8/37 (22%)
		ATS1	313..647	CDD:444065	92/373 (25%)
		RCC1 2	410..461		17/50 (34%)
		RCC1 3	462..513		14/52 (27%)
		RCC1 4	580..631		13/50 (26%)
		RCC1 5	632..684		2/7 (29%)
		RCC1	633..673	CDD:395335	2/6 (33%)