Protein Alignment niki and Stkld1

DIOPT Version :10

• Sequence 1: NP_651293.1
• Gene: niki / 42959
• FlyBaseID: FBgn0045980
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: XP_006498172.1
• Gene: Stkld1 / 279029
• MGIID: 2685557
• Length: 721
• Species: Mus musculus
• Alignment Length: 787
• Identity: 148/787 - (18%)
• Similarity: 271/787 - (34%)
• Gaps: 231/787 - (29%)

  Fly   102 LANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVS 166
            :..|:.::::..|:.|:.::........:.:.||:..  :.....:.|:.|:....||.|||:..
Mouse     1 MEKYQLLQMLNPGALGVNLVVEELETETKFLIKQVEC--IDEHHANKALEELMPLLKLQHPNLSL 63

  Fly   167 YLGSFIKDNT------LLIEMEYADGGTLAQIIA-ERQGKLHFPERYIIAVFEQISSAINYMHSE 224
            |...||..|.      |.:.|:|...||...|:. :|:.|......::..:..|:..||.|:|..
Mouse    64 YHEMFIMWNNEISSLFLCLVMDYYSQGTFQNIMENKRKLKAVVDTEWMHTMLSQVLDAIEYLHKL 128

  Fly   225 NILHRDLKTANVFLNRRGIVKIGDFGISKIMNTK----IHAQTVL---------GTP---YYFSP 273
            ||:||:||.:|:.|...|..|:.|.....:|..:    :.|:..:         |.|   .:.:|
Mouse   129 NIVHRNLKPSNIVLVNSGYCKLQDMSSQALMTHEAKWNVRAEEGVWGRLGMSGKGDPCQKSWMAP 193

  Fly   274 EMCEGKEYDNKSDIWALGCILGEM--CCLKKTFAASNLSELVTKIMAGNYTP---------VPSG 327
            |..: ..:..|||||:||||:.:|  |.......|..|.:.: :...|:..|         :|.
Mouse   194 EALK-FSFSTKSDIWSLGCIILDMATCSFLNDTEAMQLRKAI-RHHPGSLKPILKTMEEKQIPG- 255

  Fly   328 YTSGLRSLMSNLLQVEAPRRPTASEVL-VYWIPLIFRS--------------------------- 364
             |.....|:..:|.:....|....:|: |.::...|:|
Mouse   256 -TDVYYLLLPFMLHINPSDRLAIKDVMQVTFMSNSFKSSSVALNMQRQKVPIFITDVLLEGNMAN 319

  Fly   365 -LGKNKGYSYEDDV----GGPGSDQLTAPVPAAAYS---------NVSMELELPTAQTETKQLMI 415
             ||.....|:.:|.    .|.||.:|.....:.:::         |.|...|:..........|.
Mouse   320 ILGSWLCASFVNDSRHCDSGIGSQRLGFDFQSVSWTEHPLKDVMQNFSSRPEVQLRAINKLLTMP 384

  Fly   416 ADTAA---PHEILEK-RSVLYQ---------------LKAFGTCFSMAP-IQLPPKAVIVDVAMS 460
            .|...   |.|:||: .|::.|               |:..|...:..| .::|..::|:...|
Mouse   385 EDQLGLPWPTELLEEVISIIKQHGRILDILLSTCSLLLRVLGQALAKDPEAEIPRSSLIISFLM- 448

  Fly   461 DSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPS--RMESVRNYHVVSACAGDGFTILVTQA 523
                                         :..:.:|:  |:.:| .|:|::..:..|      |.
Mouse   449 -----------------------------DTLRSHPNSERLVNV-VYNVLAIISSQG------QI 477

  Fly   524 GSLLSCGSNAHLALGQDEQRNYHSPK---------LIARLADV------RVEQVAAGLQHVLA-- 571
            ...|.  ......|.|:...::...:         |.:.|.||      .:||::..:..|||
Mouse   478 SEELE--EEGLFQLAQENLEHFQEDRDICLSILSLLWSLLVDVVTVDKEPLEQLSGMVTWVLATH 540

  Fly   572 -----LSREGAVYVWGTSTCGALGLGNYQQQQKFPQKI--LLSHVKTKPSKIYCGPDTSAVLFAN 629
                 ::..|...:|..|..|.:      ::.:|.|.:  ||..::..|.:         ||..|
Mouse   541 PEDVEIAEAGCAVLWLLSLLGCI------KESQFEQVVVLLLRSIQLCPGR---------VLLVN 590

  Fly   630 GELHVCGSNDYNKLGFQRSAKITAFKKVQL--------------------PHKVTQACFSSTHSV 674
            .......|       ..:.:::.||:.|.|                    |..|...|....|..
Mouse   591 NAFRGLAS-------LAKVSELVAFRIVVLEEGSSGLHLIQDIYKLYKDDPEVVENLCMLLAHLT 648

  Fly   675 FLVEGGYVYTMGRNAEGQRGIRHCNSVDHPTLVDSVKSRYIVKANCSDQCTIVASEDNIITVWGT 739
                 .|...:.....|  ||:        .||..::.|:      :....:::..|.|:.|. .
Mouse   649 -----SYKEILPEMESG--GIK--------DLVQVIRGRF------TSSLELISYADEILQVL-E 691

  Fly   740 RNGLPGI 746
            .|..||:
Mouse   692 ANAQPGL 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	68/289 (24%)
		ATS1	433..749	CDD:444065	60/376 (16%)
Stkld1	XP_006498172.1	Protein Kinases, catalytic domain	4..286	CDD:473864	68/287 (24%)