DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment niki and Stkld1

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_006498172.1	Gene:	Stkld1 / 279029	MGIID:	2685557	Length:	721	Species:	Mus musculus

Alignment Length:	787	Identity:	148/787 - (18%)
Similarity:	271/787 - (34%)	Gaps:	231/787 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 LANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVS 166
            :..|:.::::..|:.|:.::........:.:.||:..  :.....:.|:.|:....||.|||:..
Mouse     1 MEKYQLLQMLNPGALGVNLVVEELETETKFLIKQVEC--IDEHHANKALEELMPLLKLQHPNLSL 63

  Fly   167 YLGSFIKDNT------LLIEMEYADGGTLAQIIA-ERQGKLHFPERYIIAVFEQISSAINYMHSE 224
            |...||..|.      |.:.|:|...||...|:. :|:.|......::..:..|:..||.|:|..
Mouse    64 YHEMFIMWNNEISSLFLCLVMDYYSQGTFQNIMENKRKLKAVVDTEWMHTMLSQVLDAIEYLHKL 128

  Fly   225 NILHRDLKTANVFLNRRGIVKIGDFGISKIMNTK----IHAQTVL---------GTP---YYFSP 273
            ||:||:||.:|:.|...|..|:.|.....:|..:    :.|:..:         |.|   .:.:|
Mouse   129 NIVHRNLKPSNIVLVNSGYCKLQDMSSQALMTHEAKWNVRAEEGVWGRLGMSGKGDPCQKSWMAP 193

  Fly   274 EMCEGKEYDNKSDIWALGCILGEM--CCLKKTFAASNLSELVTKIMAGNYTP---------VPSG 327
            |..: ..:..|||||:||||:.:|  |.......|..|.:.: :...|:..|         :|.
Mouse   194 EALK-FSFSTKSDIWSLGCIILDMATCSFLNDTEAMQLRKAI-RHHPGSLKPILKTMEEKQIPG- 255

  Fly   328 YTSGLRSLMSNLLQVEAPRRPTASEVL-VYWIPLIFRS--------------------------- 364
             |.....|:..:|.:....|....:|: |.::...|:|
Mouse   256 -TDVYYLLLPFMLHINPSDRLAIKDVMQVTFMSNSFKSSSVALNMQRQKVPIFITDVLLEGNMAN 319

  Fly   365 -LGKNKGYSYEDDV----GGPGSDQLTAPVPAAAYS---------NVSMELELPTAQTETKQLMI 415
             ||.....|:.:|.    .|.||.:|.....:.:::         |.|...|:..........|.
Mouse   320 ILGSWLCASFVNDSRHCDSGIGSQRLGFDFQSVSWTEHPLKDVMQNFSSRPEVQLRAINKLLTMP 384

  Fly   416 ADTAA---PHEILEK-RSVLYQ---------------LKAFGTCFSMAP-IQLPPKAVIVDVAMS 460
            .|...   |.|:||: .|::.|               |:..|...:..| .::|..::|:...|
Mouse   385 EDQLGLPWPTELLEEVISIIKQHGRILDILLSTCSLLLRVLGQALAKDPEAEIPRSSLIISFLM- 448

  Fly   461 DSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPS--RMESVRNYHVVSACAGDGFTILVTQA 523
                                         :..:.:|:  |:.:| .|:|::..:..|      |.
Mouse   449 -----------------------------DTLRSHPNSERLVNV-VYNVLAIISSQG------QI 477

  Fly   524 GSLLSCGSNAHLALGQDEQRNYHSPK---------LIARLADV------RVEQVAAGLQHVLA-- 571
            ...|.  ......|.|:...::...:         |.:.|.||      .:||::..:..|||
Mouse   478 SEELE--EEGLFQLAQENLEHFQEDRDICLSILSLLWSLLVDVVTVDKEPLEQLSGMVTWVLATH 540

  Fly   572 -----LSREGAVYVWGTSTCGALGLGNYQQQQKFPQKI--LLSHVKTKPSKIYCGPDTSAVLFAN 629
                 ::..|...:|..|..|.:      ::.:|.|.:  ||..::..|.:         ||..|
Mouse   541 PEDVEIAEAGCAVLWLLSLLGCI------KESQFEQVVVLLLRSIQLCPGR---------VLLVN 590

  Fly   630 GELHVCGSNDYNKLGFQRSAKITAFKKVQL--------------------PHKVTQACFSSTHSV 674
            .......|       ..:.:::.||:.|.|                    |..|...|....|..
Mouse   591 NAFRGLAS-------LAKVSELVAFRIVVLEEGSSGLHLIQDIYKLYKDDPEVVENLCMLLAHLT 648

  Fly   675 FLVEGGYVYTMGRNAEGQRGIRHCNSVDHPTLVDSVKSRYIVKANCSDQCTIVASEDNIITVWGT 739
                 .|...:.....|  ||:        .||..::.|:      :....:::..|.|:.|. .
Mouse   649 -----SYKEILPEMESG--GIK--------DLVQVIRGRF------TSSLELISYADEILQVL-E 691

  Fly   740 RNGLPGI 746
            .|..||:
Mouse   692 ANAQPGL 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	68/289 (24%)
		S_TKc	105..354	CDD:214567	66/282 (23%)
		ATS1	445..747	CDD:227511	57/349 (16%)
Stkld1	XP_006498172.1	S_TKc	4..286	CDD:214567	68/287 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910