DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and Sergef

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_006541006.1	Gene:	Sergef / 27414	MGIID:	1351630	Length:	465	Species:	Mus musculus

Alignment Length:	386	Identity:	108/386 - (27%)
Similarity:	144/386 - (37%)	Gaps:	115/386 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   454 IVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHY----PSRMESVRNYHVVSACAGD 514
            |..|.....|..||.:.|..:..|....|||||...|....:    |.|...:|..    ||..|
Mouse    52 IKSVTGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEEVLRFTICKPLRGCPIRQV----ACGWD 112

  Fly   515 GFTILVTQAGSLLSCGSNAHLALGQDE-QRNYHSPKLIARLADVRVEQVAAGLQHVLALSREGAV 578
             |||::|:.|.:|||||||...||... .|....|:.|..|.: :|..|||||:|.||.:..|:|
Mouse   113 -FTIMLTEKGQVLSCGSNAFGQLGVPHGPRKCVVPQAIECLRE-KVVCVAAGLRHALATTATGSV 175

  Fly   579 YVWGTSTCGALGLGNYQQQQKFPQKILLSHVKTKPSKI-----------YCGPDTSAVLFANGEL 632
            :.|||      ||.:..::....|.:.|.....:||::           ..|.|.||.|...|||
Mouse   176 FQWGT------GLASSGRRLCPGQNLPLFLTAKEPSRVTGLENSTAVCAVAGSDHSASLTDTGEL 234

  Fly   633 HVCGSNDYNKLGFQRSAKITAFKKVQLP------------HKVTQACFSSTHSVFLVEGGYVYTM 685
            :|.|.|.:.:|         |.:.|.||            .|||......||.|...|.|.|:|.
Mouse   235 YVWGRNKHGQL---------ASRAVFLPLPQRIEAHYFQDEKVTAVWSGWTHLVAKTETGKVFTW 290

  Fly   686 GRNAEGQRGIR--------------------HCNSVDHPTLVDSVKSRYIVKANCSDQCTIVA-- 728
            ||...||.|.|                    ..|||..|             .:|....|.::
Mouse   291 GRADYGQLGRRLEPPEAQKPVEQDSSLAFQGPQNSVPSP-------------LHCLTGATEISCG 342

  Fly   729 SEDNIITV------WG-TRNGLPGIGS----------------------TNCGLG--LQIC 758
            ||.|:..:      || ..:|:.|.|:                      ..||.|  |.:|
Mouse   343 SEHNLAVIRDKCCSWGWNEHGMCGDGTESNVWTPTPVQALPPSPSRLLLVGCGAGHSLAVC 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855
		S_TKc	105..354	CDD:214567
		ATS1	445..747	CDD:227511	102/349 (29%)
Sergef	XP_006541006.1	ATS1	22..370	CDD:227511	103/351 (29%)
Sergef	XP_006541006.1	RCC1	356..402	CDD:366085	9/45 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920