DRSC/TRiP Functional Genomics Resources

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Protein Alignment niki and SERGEF

DIOPT Version :9

Sequence 1:NP_651293.1 Gene:niki / 42959 FlyBaseID:FBgn0045980 Length:841 Species:Drosophila melanogaster
Sequence 2:NP_036271.1 Gene:SERGEF / 26297 HGNCID:17499 Length:458 Species:Homo sapiens


Alignment Length:368 Identity:98/368 - (26%)
Similarity:152/368 - (41%) Gaps:99/368 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   463 HFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRMESVRNYHVVSACAGDGFTILVTQAGSLL 527
            |..||.:.|..:..|....|||||...|...:: :..:|:....:.....|..|||::|:.|.:|
Human    60 HSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYF-TPCKSLFGCPIQQVACGWDFTIMLTENGQVL 123

  Fly   528 SCGSNAHLALGQDEQRNYHSPK--LIARLADVRVEQV---AAGLQHVLALSREGAVYVWGT--ST 585
            |||||:...||..     |.|:  ::.:..::..|:|   ||||:|.:|.:..|.|:.|||  ::
Human   124 SCGSNSFGQLGVP-----HGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLAS 183

  Fly   586 CGALGLGNYQQQQKFP-QKILLSHVKTKPSK-----------IYCGPDTSAVLFANGELHVCGSN 638
            ||         ::..| |.:.|.....:||:           :..|.|.||.|...||::|.|||
Human   184 CG---------RRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSN 239

  Fly   639 DYNKLGFQRSAKITAFKKVQLPHKVTQACFSS----------THSVFLVEGGYVYTMGRNAEGQR 693
            .:.:|     |...||  :.:|.|:...||.:          ||.|...|.|.::|.||...||.
Human   240 KHGQL-----ANEAAF--LPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQL 297

  Fly   694 GIRHCNSVDHPTL------------VDSVKSRYIVKANCSDQCTIVA--SEDNIITV------WG 738
            | |...:.:...|            .:|:.|    ..:|....|.|:  ||.|:..:      ||
Human   298 G-RKLETYEGWKLEKQDSFLPCSRPPNSMPS----SPHCLTGATEVSCGSEHNLAIIGGVCYSWG 357

  Fly   739 -TRNGLPGIGS--------------------TNCGLG--LQIC 758
             ..:|:.|.|:                    ..||.|  |.:|
Human   358 WNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLALC 400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nikiNP_651293.1 STKc_Nek 104..359 CDD:270855
S_TKc 105..354 CDD:214567
ATS1 445..747 CDD:227511 92/333 (28%)
SERGEFNP_036271.1 RCC1 1 15..67 3/6 (50%)
RCC1 23..64 CDD:278826 1/3 (33%)
RCC1 2 68..119 14/51 (27%)
RCC1 68..116 CDD:278826 13/48 (27%)
RCC1_2 103..132 CDD:290274 12/28 (43%)
RCC1 119..167 CDD:278826 18/52 (35%)
RCC1 3 120..171 19/55 (35%)
RCC1 4 172..230 17/66 (26%)
RCC1_2 219..243 CDD:290274 11/23 (48%)
RCC1 5 231..283 17/58 (29%)
RCC1 231..279 CDD:278826 16/54 (30%)
RCC1 6 284..351 17/71 (24%)
RCC1 284..348 CDD:278826 17/68 (25%)
RCC1 351..399 CDD:278826 9/47 (19%)
RCC1 7 352..402 10/49 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 420..458
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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