DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment niki and HERC4

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	XP_011537894.1	Gene:	HERC4 / 26091	HGNCID:	24521	Length:	1081	Species:	Homo sapiens

Alignment Length:	416	Identity:	106/416 - (25%)
Similarity:	158/416 - (37%)	Gaps:	93/416 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   454 IVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPS--------------------- 497
            ||.|:..::|.:.:|:.|..||||..:.|||||...|.....||
Human    86 IVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPSCFPKIMCVDSLVRICSGLSYG 150

  Fly   498 ---RMESVRNYHVVSACAGDGFTILVTQAGSLLSCGSNAH--LALGQDEQRNYHSPKLIARLADV 557
               .::|:.:..:|....|...::.:::|..:...|.|.:  |.||.|.::. .||:|:..|..:
Human   151 RIRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQ-TSPQLLKSLLGI 214

  Fly   558 RVEQVAAGLQHVLALSREGAVYVWGTSTCGALGLGNYQQQQKFPQKILLSHVKTKPSKIYCGPDT 622
            ...|||||..|...|:..||::.||.:..|.|||.:  :..::...:|.|....|...|.||.|.
Human   215 PFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLND--ENDRYVPNLLKSLRSQKIVYICCGEDH 277

  Fly   623 SAVLFANGELHVCGSNDYNKLGF-QRSAKITAFKKVQLPHKVTQ--ACFSSTHSVFLVEGGYVYT 684
            :|.|...|.:...|:..|.:||. ..|.:|...|..:|...:..  ||.....|.|:...|.:|:
Human   278 TAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYS 342

  Fly   685 MGRNAEGQRGIRHCNSVDHPTLVDSVKSRYIVKANCSDQCTIVASEDNIITVWGTRNG--LPGIG 747
            .|....||.|...         ..:.||.:.||.|                 |...||  ||.|.
Human   343 FGLGGNGQLGTGS---------TSNRKSPFTVKGN-----------------WYPYNGQCLPDID 381

  Fly   748 S-----------------------TNCGLGLQICTPNMELELGN-NTAAFTNFLASVYKSELILE 788
            |                       .|||.......||...::.. |.|....:|:  |.|...
Human   382 SEEYFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLS--YPSGRF-- 442

  Fly   789 PVDIL----ALFSSKEQCDRGYYVQV 810
            ||:|.    ..||| ..|..|.::.|
Human   443 PVEIANEIDGTFSS-SGCLNGSFLAV 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855
		S_TKc	105..354	CDD:214567
		ATS1	445..747	CDD:227511	85/323 (26%)
HERC4	XP_011537894.1	RCC1	2..368	CDD:332518	79/293 (27%)
HERC4	XP_011537894.1	HECTc	733..1079	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920