Protein Alignment niki and Nek3

DIOPT Version :9

• Sequence 1: NP_651293.1
• Gene: niki / 42959
• FlyBaseID: FBgn0045980
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: NP_001156419.1
• Gene: Nek3 / 23954
• MGIID: 1344371
• Length: 511
• Species: Mus musculus
• Alignment Length: 488
• Identity: 143/488 - (29%)
• Similarity: 215/488 - (44%)
• Gaps: 112/488 - (22%)

  Fly   104 NYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVSYL 168
            ||..:||:||||||.|:|..::|.......|:|.|.:   .....:..|..:.:|:.|||||::.
Mouse     3 NYTVLRVIGQGSFGRALLVLQESSNQTFAMKEIRLLK---SDTQTSRKEAVLLAKMKHPNIVAFK 64

  Fly   169 GSFIKDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDLKT 233
            .||..:..|.|.|||.|||.|.|.|.:::||| |||..|:..|.||...:|::|...:||||:|:
Mouse    65 ESFEAEGYLYIVMEYCDGGDLMQRIKQQKGKL-FPEDTILNWFIQICLGVNHIHKRRVLHRDIKS 128

  Fly   234 ANVFLNRRGIVKIGDFGISKIMNTKI-HAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEM 297
            .||||...|.||:||||.::::::.: .|.|.:|||||..||:.|...|:||||||:|||||.|:
Mouse   129 KNVFLTHNGKVKLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYEL 193

  Fly   298 CCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWI---- 358
            |.||..|.|::...|:.||..|...|:|:.|:..|:.|:..:|:.....||:|:.:|....
Mouse   194 CALKHPFQANSWKNLILKICQGPIHPLPALYSCKLQGLVKQMLKRNPSHRPSATTLLCRGSLAPL 258

  Fly   359 ------PLIFRSLGK-----------------------------NKGYSYEDDVGGPGSD---QL 385
                  |.|.|..|:                             |.....|::.|...|.   :.
Mouse   259 VPKCLPPQIIREYGEQILDEIKISTPKNMKKQDSNRVRRALGEANSASMQEEERGRKCSHTELES 323

  Fly   386 TAPVPA------AAYSNVSMELELPTAQTETKQLMIADTAAPH-------------EILEKRSVL 431
            |...||      ||..|       |.:....:.......|:||             |.|||.|:|
Mouse   324 TGTTPAGNALERAARGN-------PESGNPQEHGRHTSPASPHRPWWERHGPSSNVEALEKASIL 381

  Fly   432 ----------------YQLKAFGTCFSMAPIQLPPKAVI-----VDVAMSDSHFVVVNEDGSAYA 475
                            |:..|     ....::.||:|::     .|::.:...:.:.......:.
Mouse   382 TSSFTAEDDRGGSVIKYEENA-----RRQWVREPPEALLSMLKDADLSQAFQTYTIYRPGAEGFL 441

  Fly   476 WG--------EGTHGQLGLTALEAWKHYPSRME 500
            .|        :...|.|....|:     |.|.|
Mouse   442 KGPLSEDTASDSVDGDLDSVMLD-----PERFE 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	106/265 (40%)
		S_TKc	105..354	CDD:214567	104/249 (42%)
		ATS1	445..747	CDD:227511	11/69 (16%)
Nek3	NP_001156419.1	Interaction with VAV2. /evidence=ECO:0000250	1..282		110/282 (39%)
		PKc_like	3..255	CDD:389743	106/255 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	299..370		14/77 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..511		7/32 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820