DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment niki and nekl-1

DIOPT Version :9

Sequence 1:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster
Sequence 2:	NP_001293320.1	Gene:	nekl-1 / 189769	WormBaseID:	WBGene00021461	Length:	983	Species:	Caenorhabditis elegans

Alignment Length:	801	Identity:	253/801 - (31%)
Similarity:	381/801 - (47%)	Gaps:	129/801 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 STSLAEAMSSSKAQMPNRQESLLQLSVPRETGVGVAGPELAN----YEKVRVVGQGSFGIAILYR 123
            |..|.....||:....||:  ::::.:..|..:....|...:    ||::|.||:|:||.|:|||
Worm   127 SVRLVSRFLSSELAPHNRR--IVEIYINNEIMITNPNPRATSAQNRYERIRTVGKGAFGSAVLYR 189

  Fly   124 RKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVSYLGSFIKDNTLLIEMEYADGGT 188
            |:.|...::.|:||:.:|....|.||:|||.:.|::.||||::|..||.::..|:||||||||||
Worm   190 RREDSSLVIIKEINMYDLDSSQRRLALNEVSLLSRIEHPNIIAYYDSFEEEGVLMIEMEYADGGT 254

  Fly   189 LAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIVKIGDFGISK 253
            |||:::..|..|  .|..|..:..|:.||:.|:|..::||||||||||||.|...||||||||||
Worm   255 LAQMLSRTQNLL--DEEQIGDMMIQMCSAVAYLHENSVLHRDLKTANVFLTRDSFVKIGDFGISK 317

  Fly   254 IMNTKIHAQ---TVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKKTFAASNLSELVTK 315
            ||.|:..||   ||:|||||.|||||.|..|:.|||:|||||||.|||||||.|...||..||..
Worm   318 IMGTETLAQGAKTVVGTPYYISPEMCSGVSYNEKSDMWALGCILYEMCCLKKAFEGDNLPALVNS 382

  Fly   316 IMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIPLIFRSLGKNKGYSYEDDVGGP 380
            ||...||||...|::.::.::..|||::..:||:|.:.|....|
Worm   383 IMTCAYTPVKGPYSAEMKMVIRELLQLDPQKRPSAPQALKMLRP--------------------- 426

  Fly   381 GSDQLTAPVPAAAYSNVSMELELPTAQTETKQLMIADTAAPHEILEKRSVLYQLKAFGTCFSMAP 445
             |:........:..|:||.                             :.||.|.......|..|
Worm   427 -SENRHRHTSGSMRSSVSF-----------------------------TTLYDLHVPTITLSSIP 461

  Fly   446 IQLPPKAVIVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTALEAWKHYPSRM-ESVRNYHVVS 509
             .||.:..|..||:|.:|.:|:..|...:.:|:.:.||||.......::  .|: ||::...:.|
Worm   462 -DLPSRISIKQVALSKTHTMVLTNDNELFGFGDNSCGQLGFGKFSKMEN--GRLVESLKGRDIQS 523

  Fly   510 ACAGDGFTILVTQAGSLLSCGSNAHLALGQDEQRNYHSPKLIARLADVRVEQVAAGLQHVLALSR 574
            ...|:.|:::....|:||:.|:..:|.||:| .::...|.|:.:|....::.:..|..||:|:..
Worm   524 VGVGNYFSVICCDRGTLLTFGTAKNLGLGKD-AKDSAKPMLLEQLLRENIKDIYCGHDHVVAVLE 587

  Fly   575 EGAVYVWGTSTCGALGLGNYQQQQKF--PQKILLSHVKTKPSK---IY--CGPDTSAVLFANGEL 632
            .|....||::..|.|||...:.   |  |.||.:      ||.   :|  .|.|.:.:|..:|.|
Worm   588 SGECLGWGSNQYGQLGLPTLEH---FFAPTKIPM------PSNKKIVYGKAGKDATMLLSDDGSL 643

  Fly   633 HVCGSNDYNKLGF-QRSAKITAFKKVQ------------LPHKVTQACFSSTHSVFLVEGGYVYT 684
            ...|||.:|||.. ||....|..||..            .|.:|......|.||..::|.|.|..
Worm   644 IAMGSNKHNKLNLTQRVGFFTKEKKTPNDYVNKPTILQGFPERVVDFSVGSYHSGVILESGQVMI 708

  Fly   685 MGRNAEGQRGIRHCNSVDHPTLVDSVKS---RYIVKANCSDQCTIVASEDNIITVWGTRNGLPGI 746
            .|||...:.|:.:...: ....|..|||   .......|.|..|:|::.:..:..||.::....
Worm   709 FGRNDNTELGLGNSQKM-AVRCVKPVKSLLHHACTHVLCGDGFTLVSTTEQELYFWGRKDLTDE- 771

  Fly   747 GSTNCGLGLQICTPNME-------LELGNNTAAFTNFLASVYKSELILEPVDILALFSSKEQCDR 804
                     .:|..::|       ::.|..|        .::...::..|..||.|  ..|:.|:
Worm   772 ---------DVCIDDLEETVTEKKMKRGTTT--------EIFDKNVVTLPSLILRL--QDERGDK 817

  Fly   805 GYYVQVHDVYPLAHSVLVLVD 825
            |  :::..:......|.|.||
Worm   818 G--IRLSGLAVSGRKVHVAVD 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	133/261 (51%)
		S_TKc	105..354	CDD:214567	132/251 (53%)
		ATS1	445..747	CDD:227511	88/325 (27%)
nekl-1	NP_001293320.1	STKc_Nek	170..423	CDD:270855	133/254 (52%)
nekl-1	NP_001293320.1	ATS1	449..764	CDD:227511	88/328 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	269	1.000	Domainoid score	I977
eggNOG	1	0.900	-	-		E1_KOG0589
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H84442
Inparanoid	1	1.050	297	1.000	Inparanoid score	I1658
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48158
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	1	1.000	-	-		oto19354
orthoMCL	1	0.900	-	-		OOG6_106447
Panther	1	1.100	-	-	LDO	PTHR43671
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X891
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840